Budoprutug

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 12:14:15 GMT 2025` Edited by `admin` on `Wed Apr 02 12:14:15 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	E4ET672BAP
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Budoprutug

Official Name

English

VB-119

Preferred Name

English

VB119

Code

English

Gamma1 heavy chain (1-450) [VH Musmus/Homsap (Mus musculus IGHV1-69*02(85.7%) -(IGHD) -IGHJ4*01(100%)/Homo sapiens IGHV1-46*01 (67.3%) -(IGHD) - IGHJ4*01 (92.3%) L123>S (115), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*03 (100%),

Common Name

English

Immunoglobulin G1 [de-450-lysine], anti-(human CD19 antigen) (human-Mus musculus monoclonal VB119 ?1-chain), disulfide with human-Mus musculus monoclonal VB119 ?-chain, dimer

Common Name

English

Immunoglobulin G1-kappa, anti-[Homo sapiens CD19 (B lymphocyte surface antigen B4, Leu-12)], monoclonal antibody

Common Name

English

budoprutug [INN]

Common Name

English

Code System Code Type Description

SMS_ID

300000051884

Created by admin on Wed Apr 02 12:14:15 GMT 2025 , Edited by admin on Wed Apr 02 12:14:15 GMT 2025

PRIMARY

CAS

2720478-38-4

Created by admin on Wed Apr 02 12:14:15 GMT 2025 , Edited by admin on Wed Apr 02 12:14:15 GMT 2025

PRIMARY

INN

12546

Created by admin on Wed Apr 02 12:14:15 GMT 2025 , Edited by admin on Wed Apr 02 12:14:15 GMT 2025

PRIMARY

FDA UNII

E4ET672BAP

Created by admin on Wed Apr 02 12:14:15 GMT 2025 , Edited by admin on Wed Apr 02 12:14:15 GMT 2025

PRIMARY

NCI_THESAURUS

C203028

Created by admin on Wed Apr 02 12:14:15 GMT 2025 , Edited by admin on Wed Apr 02 12:14:15 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_147	2_203
2_223	4_211
2_264	2_324
1_147	1_203
2_370	2_428
3_23	3_87
3_131	3_191
4_23	4_87
4_131	4_191
1_223	3_211
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					IYZ9TI08W3

B-LYMPHOCYTE ANTIGEN CD19

TARGET->LIGAND

Interaction Type:

IN-VITRO, IN-VIVO

Amount:

Related Record Type Details


					E4ET672BAP

ACTIVE MOIETY

Comments:

VB119 has been shown to reduce serum B-cell populations in a Phase 1 clinical trial

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_450] [2_450]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS		Amount:	PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL