Torvutatug Samrotecan

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 17:51:21 GMT 2025` Edited by `admin` on `Wed Apr 02 17:51:21 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	E5QZ8ZF3HE
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

H-gamma1 heavy chain Homo sapiens (1-449) [VH (Homo sapiens IGHV6-1*01 (98.0%) -(IGHD) -IGHJ4*01 (100%), CDRIMGT [10.9.9] (26-35.53-61.100-108)) (1-119) -Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (216) (120-217), hinge 1-1

Preferred Name

English

Torvutatug Samrotecan

Official Name

English

torvutatug samrotecan [INN]

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens FOLR1 (folate receptor 1, folate receptor alpha, FR-alpha, adult folate-binding protein, FBP, ovarian tumor-associated antigen MOv18)], Homo sapiens monoclonal antibody; conjugated on eight cysteinyl residues t

Common Name

English

Immunoglobulin G1, anti-(human folate receptor ?) (human monoclonal INT-019 ?1-chain), complex with human monoclonal INT-019 ?-chain, dimer, octakis(thioether) with N-[31-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1,29-dioxo-4,7,10,13,16,19,22,25-octaoxa-28-

Common Name

English

Code System Code Type Description

INN

13421

Created by admin on Wed Apr 02 17:51:21 GMT 2025 , Edited by admin on Wed Apr 02 17:51:21 GMT 2025

PRIMARY

CAS

2975630-26-1

Created by admin on Wed Apr 02 17:51:21 GMT 2025 , Edited by admin on Wed Apr 02 17:51:21 GMT 2025

PRIMARY

FDA UNII

E5QZ8ZF3HE

Created by admin on Wed Apr 02 17:51:21 GMT 2025 , Edited by admin on Wed Apr 02 17:51:21 GMT 2025

PRIMARY

From	To
1_22	1_99
2_22	2_99
2_146	2_202
2_263	2_323
1_146	1_202
2_369	2_427
3_23	3_88
3_135	3_195
4_23	4_88
4_135	4_195
1_263	1_323
1_369	1_427

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_299
N	2_299

Related Record Type Details


					FUV56ZH0GB

DNA TOPOISOMERASE 1

TARGET -> INHIBITOR

Amount:


					I9G3JZ25IH

FOLATE RECEPTOR ALPHA

TARGET->LIGAND

Amount:

Related Record Type Details


					E5QZ8ZF3HE

Torvutatug Samrotecan

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC	C	Amount:	Cysteinyl samrotecan	ZJ5SH7K3UK
AMINO ACID REMOVAL	[1_449] [2_449]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL