FONADELPAR

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H23F3N2O4S
Molecular Weight	504.521
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)C1=C(CCC2=NOC3=CC(OCC(O)=O)=C(C)C=C23)SC(=N1)C4=CC=C(C=C4)C(F)(F)F

InChI

InChIKey=WWKYLBGQYALEDL-UHFFFAOYSA-N

InChI=1S/C25H23F3N2O4S/c1-13(2)23-21(35-24(29-23)15-4-6-16(7-5-15)25(26,27)28)9-8-18-17-10-14(3)19(33-12-22(31)32)11-20(17)34-30-18/h4-7,10-11,13H,8-9,12H2,1-3H3,(H,31,32)

HIDE SMILES / InChI

Molecular Formula	C25H23F3N2O4S
Molecular Weight	504.521
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://clinicaltrials.gov/ct2/show/NCT03527212 | https://clinicaltrials.gov/ct2/show/NCT02929823 | https://www.kegg.jp/dbget-bin/www_bget?dr:D10880 | http://www.senju.co.jp/english/rd/pipeline.html

Senju Pharmaceutical is developing fonadelpar (also known as SJP-0035), a peroxisome proliferator activated receptor delta agonist as an ophthalmic solution. Fonadelpar was studied in phase III clinical trial in the USA for the treatment of patients with dry eye disease. This study was successfully completed. In addition, fonadelpar was involved in phase II clinical trial in the USA for the treatment of patients with moderate to severe corneal epithelial disorders. Besides, Senju Pharmaceutical also plans a phase II trial for corneal disorders in Japan.

Originator

Approval Year

Sample Use Guides

In Vivo Use Guide

Self-administration of 1 drop (approximately 40 µL) of 0.001% SJP-0035 (FONADELPAR) ophthalmic solution into each eye 4 times daily for 4 weeks

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:08:50 GMT 2025` Edited by `admin` on `Mon Mar 31 22:08:50 GMT 2025`
Record UNII	FK5ZAD810Z
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FONADELPAR

Official Name

English

fonadelpar [INN]

Preferred Name

English

Fonadelpar [WHO-DD]

Common Name

English

SJP-0035

Code

English

(3-(2-(4-ISOPROPYL-2-(4-(TRIFLUOROMETHYL)PHENYL)-5-THIAZOLYL)ETHYL-5-METHYL-1,2-BENZISOXAZOL-6-YL)OXYACETIC ACID

Systematic Name

English

NPS-005

Code

English

FONADELPAR [USAN]

Common Name

English

ACETIC ACID, 2-((5-METHYL-3-(2-(4-(1-METHYLETHYL)-2-(4-(TRIFLUOROMETHYL)PHENYL)-5-THIAZOLYL)ETHYL)-1,2-BENZISOXAZOL-6-YL)OXY)-

Systematic Name

English

Code System Code Type Description

USAN

BC-86