MEROPENEM

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H25N3O5S.3H2O
Molecular Weight	437.508
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MEROPENEM

Structure Search

SMILES

O.O.O.[H][C@]12[C@@H](C)C(S[C@@H]3CN[C@@H](C3)C(=O)N(C)C)=C(N1C(=O)[C@]2([H])[C@@H](C)O)C(O)=O

InChI

InChIKey=CTUAQTBUVLKNDJ-OBZXMJSBSA-N

InChI=1S/C17H25N3O5S.3H2O/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4;;;/h7-12,18,21H,5-6H2,1-4H3,(H,24,25);3*1H2/t7-,8-,9+,10+,11-,12-;;;/m1.../s1

HIDE SMILES / InChI

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C17H25N3O5S
Molecular Weight	383.463
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 6
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:16:00 UTC 2023` Edited by `admin` on `Fri Dec 15 16:16:00 UTC 2023`
Record UNII	FV9J3JU8B1
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MEROPENEM

Official Name

English

ICI 194,660

Code

English

MERREM I.V.

Brand Name

English

MERONEM

Brand Name

English

MEROPENEM [USAN]

Common Name

English

MEROPENEM TRIHYDRATE

Common Name

English

NSC-759621

Code

English

Meropenem trihydrate [WHO-DD]

Common Name

English

MEROPENEM HYDRATE [JAN]

Common Name

English

MEROPENEM [VANDF]

Common Name

English

(4R,5S,6S)-3-[[(3S,5S)-5-(Dimethylcarbamoyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, trihydrate

Common Name

English

MEROPENEM HYDRATE

Common Name

English

MEROPENEM [USP-RS]

Common Name

English

MEROPENEM (AS TRIHYDRATE)

Common Name

English

MEROPENEM [USP MONOGRAPH]

Common Name

English

MEROPENEM TRIHYDRATE [MI]

Common Name

English

MEROPENEM [MART.]

Common Name

English

SM-7338

Code

English

MERREM

Brand Name

English

MEROPENEM TRIHYDRATE [EP MONOGRAPH]

Common Name

English

MEROPENEM [ORANGE BOOK]

Common Name

English

VABOMERE COMPONENT MEROPENEM

Brand Name

English

MEROPENEM COMPONENT OF CARBAVANCE

Brand Name

English

1-AZABICYCLO(3.2.0)HEPT-2-ENE-2-CARBOXYLIC ACID, 3-((5-((DIMETHYLAMINO)CARBONYL)-3-PYRROLIDINYL)THIO)-6-(1-HYDROXYETHYL)-4-METHYL-7-OXO-, TRIHYDRATE, (4R-(3(3S*,5S*),4.ALPHA.,5.BETA.,6.BETA.(R*)))-

Common Name

English

ICI-194660

Code

English

MEROPENEM [USP IMPURITY]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QJ01DH02

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

NCI_THESAURUS

C260

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

NDF-RT

N0000175496

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

WHO-ATC

J01DH02

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

WHO-ATC

J01DH52

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

FDA ORPHAN DRUG

130799

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

LIVERTOX

NBK547861

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

Code System Code Type Description

PUBCHEM

441129

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

DRUG BANK

DB00760

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

WIKIPEDIA

MEROPENEM

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

LACTMED

Meropenem

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

ChEMBL

CHEMBL127

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

USAN

BB-52

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

FDA UNII

FV9J3JU8B1

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

RS_ITEM_NUM

1392454

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

MERCK INDEX

m7240

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

Merck Index

EVMPD

SUB21617

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

EPA CompTox

DTXSID10274179

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

MESH

C059500

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

DAILYMED

FV9J3JU8B1

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

NSC

759621

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

CHEBI

6770

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

DRUG CENTRAL

1709

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

SMS_ID

100000085626

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

RXCUI

29561

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

RxNorm

CHEBI

43968

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

NCI_THESAURUS

C1160

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

CAS

119478-56-7

Created by admin on Fri Dec 15 16:16:01 UTC 2023 , Edited by admin on Fri Dec 15 16:16:01 UTC 2023

PRIMARY

Related Record Type Details


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					ZWJ2Y6JZWY

OAT-3

TRANSPORTER -> SUBSTRATE


					YOP6PX0BAO

MEROPENEM ANHYDROUS

ANHYDROUS->SOLVATE


					FV9J3JU8B1

MEROPENEM

EXCRETED UNCHANGED

Comments:

Meropenem: approximately 40–60% of dose was excreted unchanged within 24 to 48 hours with a further 28% recovered as the microbiologically inactive hydrolysis product; fecal elimination accounts for ~2% of dose.


					YOP6PX0BAO

MEROPENEM ANHYDROUS

PARENT -> SALT/SOLVATE


					I81U7H57XI

OAT-1

TRANSPORTER -> SUBSTRATE

Related Record Type Details


					4MC3K7LDC6

MEROPENEM OPEN RING

IMPURITY -> PARENT

Comments:

correction factor: for the calculation of content, multiply the peak area of impurity A by 1.6

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					G6636F29A1

MEROPENEM DIMER

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

Related Record Type Details


					YOP6PX0BAO

MEROPENEM ANHYDROUS

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC