MEROPENEM ANHYDROUS

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H25N3O5S
Molecular Weight	383.463
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MEROPENEM ANHYDROUS

Structure Search

SMILES

[H][C@]12[C@@H](C)C(S[C@@H]3CN[C@@H](C3)C(=O)N(C)C)=C(N1C(=O)[C@]2([H])[C@@H](C)O)C(O)=O

InChI

InChIKey=DMJNNHOOLUXYBV-PQTSNVLCSA-N

InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8-,9+,10+,11-,12-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C17H25N3O5S
Molecular Weight	383.463
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 6
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:32:54 UTC 2023` Edited by `admin` on `Fri Dec 15 15:32:54 UTC 2023`
Record UNII	YOP6PX0BAO
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MEROPENEM ANHYDROUS

Common Name

English

MEROPENEM [MI]

Common Name

English

MEROPENEM, ANHYDROUS

Common Name

English

meropenem [INN]

Common Name

English

(4R,5S,6S)-3-(((3S,5S)-5-(DIMETHYLCARBAMOYL)-3-PYRROLIDINYL)THIO)-6-((1R)-1-HYDROXYETHYL)-4-METHYL-7-OXO-1-AZABICYCLO(3.2.0)HEPT-2-ENE-2-CARBOXYLIC ACID

Systematic Name

English

Meropenem [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C260

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

NDF-RT

N0000011294

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

NDF-RT

N0000011294

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

NDF-RT

N0000175496

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

WHO-ATC

J01DH02

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

NDF-RT

N0000011294

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

NDF-RT

N0000011294

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

NDF-RT

N0000011294

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

NDF-RT

N0000011294

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

NDF-RT

N0000011294

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

NDF-RT

N0000011294

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

NDF-RT

N0000011294

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

Code System Code Type Description

SMS_ID

100000133073

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

PRIMARY

CAS

96036-03-2

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

PRIMARY

FDA UNII

YOP6PX0BAO

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

PRIMARY

CHEBI

43968

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

PRIMARY

RXCUI

1546029

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

PRIMARY

RxNorm

EVMPD

SUB08778MIG

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

PRIMARY

PUBCHEM

441130

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

PRIMARY

HSDB

8019

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

PRIMARY

DAILYMED

YOP6PX0BAO

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

PRIMARY

INN

6396

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

PRIMARY

NCI_THESAURUS

C61833

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

PRIMARY

EVMPD

SUB49628

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

PRIMARY

EPA CompTox

DTXSID7045526

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

PRIMARY

MERCK INDEX

m7240

Created by admin on Fri Dec 15 15:32:54 UTC 2023 , Edited by admin on Fri Dec 15 15:32:54 UTC 2023

PRIMARY

Merck Index

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					FV9J3JU8B1

MEROPENEM

SOLVATE->ANHYDROUS


					HWA8Y5DYZ8

PENICILLIN-BINDING PROTEIN 1B

TARGET -> INHIBITOR


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					FV9J3JU8B1

MEROPENEM

SALT/SOLVATE -> PARENT


					M0GJ81KC9Z

D-ALANYL-D-ALANINE CARBOXYPEPTIDASE DACB

TARGET -> INHIBITOR


					PH1LUU2COI

PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA

TARGET -> INHIBITOR


					PLW8GC3JKC

OXA-48 (Beta-lactamase)

ENZYME->SUBSTRATE

Comments:

Low level activity could still lead to resistance to the antibiotic.

Amount:


					BP3X0IS38L

PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI

TARGET -> INHIBITOR


					YOP6PX0BAO

MEROPENEM ANHYDROUS

EXCRETED UNCHANGED

Amount:


					6LJ3NWM7AZ

MEROPENEM SODIUM CARBONATE

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					9H9WBH911Y

METABOLITE -> PARENT

Comments:

Mediator: DHP-I

Interaction Type:

MAJOR

Qualification:

PLASMA


					9H9WBH911Y

METABOLITE INACTIVE -> PARENT

Interaction Type:

MAJOR

Qualification:

URINE

Amount:

Related Record Type Details


					YOP6PX0BAO

MEROPENEM ANHYDROUS

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Volume of Distribution	PHARMACOKINETIC				Adult PHARMACOKINETIC Children PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC				Population Children and Adults Population Infants < mo