U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Wed Apr 02 01:11:56 GMT 2025
Edited
by admin
on Wed Apr 02 01:11:56 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
G72T8FL60W
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SPHINGOSINE 1-PHOSPHATE RECEPTOR 1
Common Name English
CD363
Preferred Name English
S1P1
Common Name English
EDG1
Common Name English
S1PR1
Common Name English
SPHINGOSINE 1-PHOSPHATE RECEPTOR EDG-1
Common Name English
S1P RECEPTOR EDG-1
Common Name English
S1P RECEPTOR 1
Common Name English
ENDOTHELIAL DIFFERENTIATION G-PROTEIN COUPLED RECEPTOR 1
Common Name English
CHEDG1
Common Name English
Code System Code Type Description
UNIPROT
P21453
Created by admin on Wed Apr 02 01:11:56 GMT 2025 , Edited by admin on Wed Apr 02 01:11:56 GMT 2025
PRIMARY
WIKIPEDIA
S1PR1
Created by admin on Wed Apr 02 01:11:56 GMT 2025 , Edited by admin on Wed Apr 02 01:11:56 GMT 2025
PRIMARY
FDA UNII
G72T8FL60W
Created by admin on Wed Apr 02 01:11:56 GMT 2025 , Edited by admin on Wed Apr 02 01:11:56 GMT 2025
PRIMARY
From To
1_183 1_190
1_281 1_286
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_29
N 1_35
Related Record Type Details
AGONIST -> TARGET
SELECTIVE
AGONIST -> TARGET
IN-VITRO, IN-VIVO
AGONIST -> TARGET
EC50
AGONIST -> TARGET
vivo phosphorylation of FTY720 (1) in rats and humans resulted exclusively in the biologically active (S)-configured enantiomer
AGONIST
AGONIST -> TARGET
Siponimod promotes internalization and degradation of S1P1 receptors, thereby acting as a functional antagonist on S1P1. Blocks the capacity of lymphocytes to egress from lymph nodes, reducing the number of lymphocytes in peripheral blood.
EC50
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
SELECTIVE
AGONIST -> TARGET
SELECTIVE
RADIOLIGAND->TARGET
IC50
AGONIST -> TARGET
SELECTIVE
MODULATOR->TARGET
AGONIST -> TARGET
SELECTIVE
AGONIST -> TARGET
Emax = 126%. Chinese Hamster Ovary (CHO) cells, overexpressing human S1P1 receptor (35S)-GTP-S incorporation assays.
EC50
AGONIST -> TARGET
AGONIST -> TARGET
EC50
AGONIST -> TARGET
SELECTIVE
AGONIST -> TARGET
EC50

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_9] LYSINE N6-ACETYLLYSINE 470AD5VY1X
AMINO ACID SUBSTITUTION [1_350] [1_352] SERINE DEXFOSFOSERINE VI4F0K069V
AMINO ACID SUBSTITUTION [1_235] THREONINE THREONINE PHOSPHATE 3L4WX7B1EI
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL