Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Wed Apr 02 01:11:56 GMT 2025
by
admin
on
Wed Apr 02 01:11:56 GMT 2025
|
| Protein Sub Type | |
| Sequence Type | COMPLETE |
| Record UNII |
G72T8FL60W
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Common Name | English | ||
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Preferred Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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P21453
Created by
admin on Wed Apr 02 01:11:56 GMT 2025 , Edited by admin on Wed Apr 02 01:11:56 GMT 2025
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PRIMARY | |||
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S1PR1
Created by
admin on Wed Apr 02 01:11:56 GMT 2025 , Edited by admin on Wed Apr 02 01:11:56 GMT 2025
|
PRIMARY | |||
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G72T8FL60W
Created by
admin on Wed Apr 02 01:11:56 GMT 2025 , Edited by admin on Wed Apr 02 01:11:56 GMT 2025
|
PRIMARY |
| From | To |
|---|---|
| 1_183 | 1_190 |
| 1_281 | 1_286 |
| Glycosylation Type | HUMAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_29 |
| N | 1_35 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
AGONIST -> TARGET |
SELECTIVE
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||
|
AGONIST -> TARGET |
IN-VITRO, IN-VIVO
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AGONIST -> TARGET |
EC50
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AGONIST -> TARGET |
vivo phosphorylation of FTY720 (1) in rats and humans resulted exclusively in the biologically
active (S)-configured enantiomer
AGONIST
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|
AGONIST -> TARGET |
Siponimod promotes internalization and degradation of S1P1
receptors, thereby acting as a functional antagonist on S1P1. Blocks the capacity of lymphocytes to egress from lymph nodes, reducing the number of lymphocytes in peripheral blood.
EC50
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|
AGONIST -> TARGET |
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AGONIST -> TARGET | |||
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AGONIST -> TARGET | |||
|
AGONIST -> TARGET |
SELECTIVE
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AGONIST -> TARGET |
SELECTIVE
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RADIOLIGAND->TARGET |
IC50
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AGONIST -> TARGET |
SELECTIVE
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MODULATOR->TARGET |
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AGONIST -> TARGET |
SELECTIVE
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AGONIST -> TARGET |
Emax = 126%. Chinese Hamster Ovary (CHO) cells, overexpressing human S1P1 receptor (35S)-GTP-S incorporation assays.
EC50
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|
AGONIST -> TARGET | |||
|
AGONIST -> TARGET |
EC50
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|
AGONIST -> TARGET |
SELECTIVE
|
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|
AGONIST -> TARGET |
EC50
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Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| AMINO ACID SUBSTITUTION | [1_9] | LYSINE | N6-ACETYLLYSINE | 470AD5VY1X | ||
| AMINO ACID SUBSTITUTION | [1_350] [1_352] | SERINE | DEXFOSFOSERINE | VI4F0K069V | ||
| AMINO ACID SUBSTITUTION | [1_235] | THREONINE | THREONINE PHOSPHATE | 3L4WX7B1EI |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) | CHEMICAL |
|