U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 19:08:53 GMT 2025
Edited
by admin
on Tue Apr 01 19:08:53 GMT 2025
Protein Type KINASE
Protein Sub Type TYROSINE KINASE
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
GL209F9TZS
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TYROSINE-PROTEIN KINASE JAK2
Common Name English
JAK-2
Preferred Name English
JAK2
Common Name English
RECEPTOR-ASSOCIATED TYROSINE KINASE (HUMAN GENE JAK2)
Common Name English
JANUS KINASE 2
Common Name English
Code System Code Type Description
CAS
479842-25-6
Created by admin on Tue Apr 01 19:08:53 GMT 2025 , Edited by admin on Tue Apr 01 19:08:53 GMT 2025
ALTERNATIVE
FDA UNII
GL209F9TZS
Created by admin on Tue Apr 01 19:08:53 GMT 2025 , Edited by admin on Tue Apr 01 19:08:53 GMT 2025
PRIMARY
CAS
391968-59-5
Created by admin on Tue Apr 01 19:08:53 GMT 2025 , Edited by admin on Tue Apr 01 19:08:53 GMT 2025
PRIMARY
WIKIPEDIA
JANUS KINASE 2
Created by admin on Tue Apr 01 19:08:53 GMT 2025 , Edited by admin on Tue Apr 01 19:08:53 GMT 2025
PRIMARY
UNIPROT
O60674
Created by admin on Tue Apr 01 19:08:53 GMT 2025 , Edited by admin on Tue Apr 01 19:08:53 GMT 2025
PRIMARY
PHAROS
O60674
Created by admin on Tue Apr 01 19:08:53 GMT 2025 , Edited by admin on Tue Apr 01 19:08:53 GMT 2025
PRIMARY
EC (ENZYME CLASS)
EC 2.7.10.2
Created by admin on Tue Apr 01 19:08:53 GMT 2025 , Edited by admin on Tue Apr 01 19:08:53 GMT 2025
PRIMARY
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Structure of ITACITINIB
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Structure of BARICITINIB
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Structure of Delgocitinib
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Structure of DECERNOTINIB
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Structure of LESTAURTINIB
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Structure of BMS-911543
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Structure of PYRIDONE-6
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Structure of PEFICITINIB
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Structure of K-00546
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Structure of ILGINATINIB
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Structure of MOMELOTINIB
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Structure of PACRITINIB
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INHIBITOR -> TARGET
Structure of Tofacitinib
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Structure of XL-019
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Structure of DEUCRAVACITINIB
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Structure of FEDRATINIB
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Structure of TUL-01101
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COMPETITIVE INHIBITOR
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Structure of UPADACITINIB
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Structure of MIDOSTAURIN
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Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_523] SERINE DEXFOSFOSERINE VI4F0K069V
MOIETY MAGNESIUM CATION T6V3LHY838
AMINO ACID SUBSTITUTION [1_119] [1_372] [1_373] [1_813] [1_868] [1_966] [1_972] [1_1007] [1_1008] TYROSINE TYROSINE O-PHOSPHATE 2R86C98KDX
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL
NIH
NCATS
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