MIDOSTAURIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C35H30N4O4
Molecular Weight	570.6371
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MIDOSTAURIN

Structure Search

SMILES

[H][C@]12C[C@H]([C@@H](OC)[C@](C)(O1)N3C4=CC=CC=C4C5=C6CNC(=O)C6=C7C8=C(C=CC=C8)N2C7=C35)N(C)C(=O)C9=CC=CC=C9

InChI

InChIKey=BMGQWWVMWDBQGC-IIFHNQTCSA-N

InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C35H30N4O4
Molecular Weight	570.6371
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:33:40 UTC 2023` Edited by `admin` on `Fri Dec 15 15:33:40 UTC 2023`
Record UNII	ID912S5VON
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MIDOSTAURIN

Official Name

English

MIDOSTAURIN [ORANGE BOOK]

Common Name

English

CGP 41251

Code

English

PKC 412

Code

English

NSC-656576

Code

English

RYDAPT

Brand Name

English

midostaurin [INN]

Common Name

English

CGP-41251

Code

English

MIDOSTAURIN [MI]

Common Name

English

N-((9S,10R,11R,13R)-10-METHOXY-9-METHYL-1-OXO-2,3,10,11,12,13-HEXAHYDRO-9,13-EPOXY-1H,9H-DIINDOLO(1,2,3-GH:3',2',1'-LM)PYRROLO(3,4-J)(1,7)BENZODIAZONIN-11-YL)-N-METHYLBENZAMIDE

Common Name

English

NVP-PKC412

Code

English

Midostaurin [WHO-DD]

Common Name

English

MIDOSTAURIN [JAN]

Common Name

English

PKC-412

Code

English

MIDOSTAURIN [USAN]

Common Name

English

MIDOSTAURIN [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1742

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

EU-Orphan Drug

EU/3/10/765

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

FDA ORPHAN DRUG

306410

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

WHO-ATC

L01XE39

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

NCI_THESAURUS

C2089

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

NDF-RT

N0000175605

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

FDA ORPHAN DRUG

285909

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

Code System Code Type Description

NSC

656576

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

INN

7677

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

ChEMBL

CHEMBL608533

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

DRUG CENTRAL

5231

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

RXCUI

1919083

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

NCI_THESAURUS

C1872

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

PUBCHEM

9829523

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

DAILYMED

ID912S5VON

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

USAN

QQ-30

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

CAS

120685-11-2

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

FDA UNII

ID912S5VON

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

DRUG BANK

DB06595

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

MESH

C411007

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

SMS_ID

100000088079

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

LACTMED

Midostaurin

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

CHEBI

63452

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

EVMPD

SUB21040

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

MERCK INDEX

m7534

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

Merck Index

EPA CompTox

DTXSID40923522

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

WIKIPEDIA

Midostaurin

Created by admin on Fri Dec 15 15:33:40 UTC 2023 , Edited by admin on Fri Dec 15 15:33:40 UTC 2023

PRIMARY

Related Record Type Details


					OVI08ABI5H

MAST/STEM CELL GROWTH FACTOR RECEPTOR KIT

TARGET -> INHIBITOR

Interaction Type:

INHIBITOR

Qualification:

IC50

Amount:


					08S4A2S6FT

TYROSINE-PROTEIN KINASE JAK1

TARGET -> INHIBITOR


					HQ6Z0L08Y3

RIBOSOMAL PROTEIN S6 KINASE ALPHA-1

TARGET -> INHIBITOR


					KY25K9D5AA

INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT EPSILON

TARGET -> INHIBITOR


					GL209F9TZS

TYROSINE-PROTEIN KINASE JAK2

TARGET -> INHIBITOR


					JS20X60RRY

TYROSINE-PROTEIN KINASE SYK

TARGET -> INHIBITOR

Interaction Type:

INHIBITOR

Qualification:

IC50

Amount:


					DNV5PYD2QS

RECEPTOR-TYPE TYROSINE-PROTEIN KINASE FLT3 D835Y

TARGET -> INHIBITOR


					S344CKA15F

FIBROBLAST GROWTH FACTOR RECEPTOR 2

TARGET -> INHIBITOR

Interaction Type:

INHIBITOR

Qualification:

IC50

Amount:


					ORH3YB25JY

SERINE/THREONINE-PROTEIN KINASE N2

TARGET -> INHIBITOR


					YDL509611I

CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA

TARGET -> INHIBITOR


					5K47RF8GE8

MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 11

TARGET -> INHIBITOR


					3AZ1VUF0Q7

MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE

TARGET -> INHIBITOR


					798536Z7S0

VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2

TARGET -> INHIBITOR

Interaction Type:

INHIBITOR

Qualification:

IC50

Amount:


					9B09G8YMGH

PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA

TARGET -> INHIBITOR

Interaction Type:

INHIBITOR

Qualification:

IC50

Amount:


					4796L35A70

RECEPTOR-TYPE TYROSINE-PROTEIN KINASE FLT3

TARGET -> INHIBITOR

Interaction Type:

INHIBITOR

Qualification:

IC50

Amount:


					2VXO9I489U

MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR

TARGET -> INHIBITOR

Interaction Type:

INHIBITOR

Qualification:

IC50

Amount:


					EXBA2DRFUB

PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA

TARGET -> INHIBITOR

Interaction Type:

INHIBITOR

Qualification:

IC50

Amount:


					EL8FEW3TUM

MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE

TARGET -> INHIBITOR


					9LLR266790

TYROSINE-PROTEIN KINASE JAK3

TARGET -> INHIBITOR


					X35J4F8MAB

PROTEIN KINASE C GAMMA TYPE

TARGET -> INHIBITOR

Interaction Type:

INHIBITOR

Qualification:

IC50

Amount:

Related Record Type Details


					H3W3QJ5C7G

CGP-62221

METABOLITE ACTIVE -> PARENT


					D9B1PJ9MWX

CGP-52421

METABOLITE LESS ACTIVE -> PARENT

Related Record Type Details


					ID912S5VON

ACTIVE MOIETY