AMBRISENTAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H22N2O4
Molecular Weight	378.4211
Optical Activity	( + )
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of AMBRISENTAN

Structure Search

SMILES

COC([C@H](OC1=NC(C)=CC(C)=N1)C(O)=O)(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=OUJTZYPIHDYQMC-LJQANCHMSA-N

InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C22H22N2O4
Molecular Weight	378.4211
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:32:57 UTC 2023` Edited by `admin` on `Sat Dec 16 17:32:57 UTC 2023`
Record UNII	HW6NV07QEC
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

AMBRISENTAN

Official Name

English

AMBRISENTAN [MI]

Common Name

English

(+)-(2S)-2-((4,6-DIMETHYLPYRIMIDIN-2-YL)OXY)-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID

Systematic Name

English

AMBRISENTAN [JAN]

Common Name

English

GSK1325760

Code

English

AMBRISENTAN [ORANGE BOOK]

Common Name

English

GSK-1325760

Code

English

LU-208075

Code

English

LETAIRIS

Brand Name

English

VOLIBRIS

Brand Name

English

AMBRISENTAN [MART.]

Common Name

English

GSK1325760A

Code

English

ambrisentan [INN]

Common Name

English

AMBRISENTAN [EMA EPAR]

Common Name

English

Ambrisentan [WHO-DD]

Common Name

English

GSK-1325760A

Code

English

AMBRISENTAN [VANDF]

Common Name

English

AMBRISENTAN, (+)-

Common Name

English

Classification Tree Code System Code

WHO-ATC

C02KX52

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

LIVERTOX

NBK548675

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

WHO-VATC

QC02KX02

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

WHO-ATC

C02KX02

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

EMA ASSESSMENT REPORTS

VOLIBRIS (AUTHORIZED: HYPERTENSION, PULMONARY)

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

NCI_THESAURUS

C270

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

EU-Orphan Drug

EU/3/05/273

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

NDF-RT

N0000175581

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

NDF-RT

N0000175364

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

Code System Code Type Description

MERCK INDEX

m1648

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

PRIMARY

Merck Index

RXCUI

358274

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

PRIMARY

RxNorm

CAS

177036-94-1

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

PRIMARY

PUBCHEM

6918493

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

PRIMARY

ChEMBL

CHEMBL1111

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

PRIMARY

SMS_ID

100000089441

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

PRIMARY

DRUG CENTRAL

4337

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

PRIMARY

IUPHAR

3951

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

PRIMARY

DRUG BANK

DB06403

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

PRIMARY

DAILYMED

HW6NV07QEC

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

PRIMARY

NCI_THESAURUS

C72694

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

PRIMARY

FDA UNII

HW6NV07QEC

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

PRIMARY

EPA CompTox

DTXSID4046282

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

PRIMARY

MESH

C467894

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

PRIMARY

INN

8128

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

PRIMARY

EVMPD

SUB25424

Created by admin on Sat Dec 16 17:32:58 UTC 2023 , Edited by admin on Sat Dec 16 17:32:58 UTC 2023

PRIMARY

Related Record Type Details


					HW6NV07QEC

EXCRETED UNCHANGED

Interaction Type:

AMOUNT EXCRETED

Qualification:

FECAL

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE


					HW6NV07QEC

EXCRETED UNCHANGED

Interaction Type:

AMOUNT EXCRETED

Qualification:

URINE

Amount:


					081I12ZA58

CYTOCHROME P450 2C19

METABOLIC ENZYME -> SUBSTRATE


					5Q6PN7AC39

ENDOTHELIN-1 RECEPTOR

TARGET -> INHIBITOR

Interaction Type:

ANTAGONIST


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Related Record Type Details


					5EH35FF002

AMBRISENTAN ACYL .BETA.-D-GLUCURONIDE

METABOLITE -> PARENT

Amount:


					Q55T0406HK

4-HYDROXYMETHYL AMBRISENTAN

PARENT -> METABOLITE

Amount:


					V4FC3H4Y2E

4-HYDROXYMETHYL AMBRISENTAN GLUCURONIDE

METABOLITE -> PARENT

Amount:

Related Record Type Details


					HW6NV07QEC

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Tmax	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC