Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Tue Apr 01 18:34:32 GMT 2025
by
admin
on
Tue Apr 01 18:34:32 GMT 2025
|
| Protein Type | ENZYME |
| Protein Sub Type | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE|KINASE |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
JQ83GG8LT2
|
| Record Status |
Validated (UNII)
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| Record Version |
|
-
Download
| Name | Type | Language | ||
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Common Name | English | ||
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Preferred Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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DB14954
Created by
admin on Tue Apr 01 18:34:32 GMT 2025 , Edited by admin on Tue Apr 01 18:34:32 GMT 2025
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PRIMARY | |||
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JQ83GG8LT2
Created by
admin on Tue Apr 01 18:34:32 GMT 2025 , Edited by admin on Tue Apr 01 18:34:32 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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INHIBITOR -> TARGET |
selective for alpha isoform, and leads to degradation of mutant p110 alpha PI3K subunit.
Ki
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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WEAK INHIBITOR->TARGET | |||
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
INHIBITOR
IC50
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SUBSTRATE -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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PARENT->INNOVATOR | |||
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
Ki
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INHIBITOR -> TARGET |
IC50
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||
|
INHIBITOR -> TARGET | |||
|
INHIBITOR -> TARGET |
STX-478 is a second-generation, allosteric, mutant-selective, PI3K? small molecule inhibitor
ALLOSTERIC
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MUTANT->PARENT |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
Allosteric PI3K? inhibitor
ALLOSTERIC
IC50
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MUTANT->PARENT |
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INHIBITOR -> TARGET |
ADP-Glo
IC50
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INHIBITOR -> TARGET | |||
|
INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET | |||
|
INHIBITOR -> TARGET | |||
|
INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
IC50
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||
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WEAK INHIBITOR->OFF TARGET |
IC50
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||
|
INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
INHIBITOR
IC50
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NON-INHIBITOR->OFF TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
Ki
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
Highly selective PI3K? inhibitor when tested at 1 ?M in a broad kinase panel (344 assays). >1000-fold selective over the members of
class 2 (PI3K-C2?, PI3K-C2?), class 3 (hVPS34), and class 4 (PI3K?, PI4K?) groups of the PI3K family, PI3K-related (DNA-PK, mTOR) kinase family.
Ki
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INHIBITOR -> TARGET |
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
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| Molecular Formula | CHEMICAL |
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