FIMEPINOSTAT

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H24N8O4S
Molecular Weight	508.553
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of FIMEPINOSTAT

Structure Search

SMILES

COC1=CC=C(C=N1)C2=NC(N3CCOCC3)=C4SC(CN(C)C5=NC=C(C=N5)C(=O)NO)=CC4=N2

InChI

InChIKey=JOWXJLIFIIOYMS-UHFFFAOYSA-N

InChI=1S/C23H24N8O4S/c1-30(23-25-11-15(12-26-23)22(32)29-33)13-16-9-17-19(36-16)21(31-5-7-35-8-6-31)28-20(27-17)14-3-4-18(34-2)24-10-14/h3-4,9-12,33H,5-8,13H2,1-2H3,(H,29,32)

HIDE SMILES / InChI

Molecular Formula	C23H24N8O4S
Molecular Weight	508.553
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:58:24 UTC 2023` Edited by `admin` on `Sat Dec 16 10:58:24 UTC 2023`
Record UNII	3S9RX35S5X
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FIMEPINOSTAT

Official Name

English

N-Hydroxy-2-[{[2-(6-methoxypyridin-3-yl)-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl}(methyl)amino]pyrimidine-5-carboxamide

Systematic Name

English

FIMEPINOSTAT [USAN]

Common Name

English

fimepinostat [INN]

Common Name

English

5-PYRIMIDINECARBOXAMIDE, N-HYDROXY-2-(((2-(6-METHOXY-3-PYRIDINYL)-4-(4-MORPHOLINYL)THIENO(3,2-D)PYRIMIDIN-6-YL)METHYL)METHYLAMINO)-

Systematic Name

English

PI3K/HDAC INHIBITOR CUDC-907

Common Name

English

CUDC907

Code

English

Fimepinostat [WHO-DD]

Common Name

English

CUDC-907

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C129825

Created by admin on Sat Dec 16 10:58:24 UTC 2023 , Edited by admin on Sat Dec 16 10:58:24 UTC 2023

NCI_THESAURUS

C1404

Created by admin on Sat Dec 16 10:58:24 UTC 2023 , Edited by admin on Sat Dec 16 10:58:24 UTC 2023

NCI_THESAURUS

C1946

Created by admin on Sat Dec 16 10:58:24 UTC 2023 , Edited by admin on Sat Dec 16 10:58:24 UTC 2023

FDA ORPHAN DRUG

467814

Created by admin on Sat Dec 16 10:58:24 UTC 2023 , Edited by admin on Sat Dec 16 10:58:24 UTC 2023

FDA ORPHAN DRUG

482415

Created by admin on Sat Dec 16 10:58:24 UTC 2023 , Edited by admin on Sat Dec 16 10:58:24 UTC 2023

Code System Code Type Description

EPA CompTox

DTXSID90712307

Created by admin on Sat Dec 16 10:58:24 UTC 2023 , Edited by admin on Sat Dec 16 10:58:24 UTC 2023

PRIMARY

USAN

DE-36

Created by admin on Sat Dec 16 10:58:24 UTC 2023 , Edited by admin on Sat Dec 16 10:58:24 UTC 2023

PRIMARY

INN

10504

Created by admin on Sat Dec 16 10:58:24 UTC 2023 , Edited by admin on Sat Dec 16 10:58:24 UTC 2023

PRIMARY

SMS_ID

100000181111

Created by admin on Sat Dec 16 10:58:24 UTC 2023 , Edited by admin on Sat Dec 16 10:58:24 UTC 2023

PRIMARY

DRUG BANK

DB11891

Created by admin on Sat Dec 16 10:58:24 UTC 2023 , Edited by admin on Sat Dec 16 10:58:24 UTC 2023

PRIMARY

CAS

1339928-25-4

Created by admin on Sat Dec 16 10:58:24 UTC 2023 , Edited by admin on Sat Dec 16 10:58:24 UTC 2023

PRIMARY

FDA UNII

3S9RX35S5X

Created by admin on Sat Dec 16 10:58:24 UTC 2023 , Edited by admin on Sat Dec 16 10:58:24 UTC 2023

PRIMARY

PUBCHEM

54575456

Created by admin on Sat Dec 16 10:58:24 UTC 2023 , Edited by admin on Sat Dec 16 10:58:24 UTC 2023

PRIMARY

ChEMBL

CHEMBL3545052

Created by admin on Sat Dec 16 10:58:24 UTC 2023 , Edited by admin on Sat Dec 16 10:58:24 UTC 2023

PRIMARY

NCI_THESAURUS

C104008

Created by admin on Sat Dec 16 10:58:24 UTC 2023 , Edited by admin on Sat Dec 16 10:58:24 UTC 2023

PRIMARY

Related Record Type Details


					O037NFL7YQ

HISTONE DEACETYLASE 1

TARGET -> INHIBITOR


					B618F4630I

FIMEPINOSTAT MESYLATE

SALT/SOLVATE -> PARENT


					JQ83GG8LT2

PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM

TARGET -> INHIBITOR


					O037NFL7YQ

HISTONE DEACETYLASE 1

TARGET -> INHIBITOR

Comments:

CUDC-907 is a dual PI3K.ALPHA. and HDAC1 inhibitor. Phase 1.

Interaction Type:

INHIBITOR

Qualification:

IC50

Amount:


					RV2QAE6UDF

HISTONE DEACETYLASE 2

TARGET -> INHIBITOR

Comments:

CUDC-907 is a dual PI3K.ALPHA. and HDAC2 inhibitor. Phase 1.

Interaction Type:

INHIBITOR

Qualification:

IC50

Amount:


					7YNS2RVD5Q

HISTONE DEACETYLASE 3

TARGET -> INHIBITOR

Comments:

CUDC-907 is a dual PI3K.ALPHA. and HDAC3 inhibitor. Phase 1.

Interaction Type:

INDUCER

Qualification:

IC50

Amount:


					3ADC8Y5OGH

HISTONE DEACETYLASE 10

TARGET -> INHIBITOR

Comments:

CUDC-907 is a dual PI3K.ALPHA. and HDAC10 inhibitor. Phase 1.

Interaction Type:

INHIBITOR

Qualification:

IC50

Amount:

Related Record Type Details


					3S9RX35S5X

ACTIVE MOIETY