Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Tue Apr 01 18:13:02 GMT 2025
by
admin
on
Tue Apr 01 18:13:02 GMT 2025
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| Protein Sub Type | |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
JS20X60RRY
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| Record Status |
Validated (UNII)
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| Record Version |
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-
Download
| Name | Type | Language | ||
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Common Name | English | ||
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Preferred Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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SYK
Created by
admin on Tue Apr 01 18:13:02 GMT 2025 , Edited by admin on Tue Apr 01 18:13:02 GMT 2025
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PRIMARY | |||
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P43405
Created by
admin on Tue Apr 01 18:13:02 GMT 2025 , Edited by admin on Tue Apr 01 18:13:02 GMT 2025
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PRIMARY | |||
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JS20X60RRY
Created by
admin on Tue Apr 01 18:13:02 GMT 2025 , Edited by admin on Tue Apr 01 18:13:02 GMT 2025
|
PRIMARY | |||
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P43405
Created by
admin on Tue Apr 01 18:13:02 GMT 2025 , Edited by admin on Tue Apr 01 18:13:02 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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INHIBITOR -> TARGET |
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WEAK INHIBITOR->TARGET |
Enzyme inhibition
IC50
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
Dropped from clinical trials because of adverse events probably bleeding.
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
inhibited its kinase activity as an ATP-competitive inhibitor (Ki = 30 nM)
COMPETITIVE INHIBITOR
Ki
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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![Structure of N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N?-[4-[[2-(phenylamino)-4-pyrimidinyl]oxy]-1-naphthalenyl]urea](/img/aba6147e-73c3-4a00-bb0c-3de192f48ea3.svg "Structure of N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N?-[4-[[2-(phenylamino)-4-pyrimidinyl]oxy]-1-naphthalenyl]urea")
Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| AMINO ACID SUBSTITUTION | [1_44] [1_202] [1_295] [1_297] [1_316] [1_319] [1_350] [1_379] [1_579] | DEXFOSFOSERINE | VI4F0K069V |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| Molecular Formula | CHEMICAL |
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| MOL_WEIGHT | CHEMICAL |
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