Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C21H27NO5 |
| Molecular Weight | 373.4428 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@H](NCCC1=CC(C)=C(OCC(O)=O)C=C1C)[C@H](O)C2=CC=C(O)C=C2
InChI
InChIKey=VMMYRRFPMAGXNP-BTYIYWSLSA-N
InChI=1S/C21H27NO5/c1-13-11-19(27-12-20(24)25)14(2)10-17(13)8-9-22-15(3)21(26)16-4-6-18(23)7-5-16/h4-7,10-11,15,21-23,26H,8-9,12H2,1-3H3,(H,24,25)/t15-,21-/m0/s1
| Molecular Formula | C21H27NO5 |
| Molecular Weight | 373.4428 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Ritobegron (KUC 7483) is a selective β3-adrenoceptor agonist that was developed for oral treatment of overactive bladder. It is the prodrug of the active compound KUC-7322. Phase I studies have investigated the pharmacodynamic and pharmacokinetic effects of ritobegron in healthy individuals and patients with spinal cord injury. Ritobegron exhibits a high selectivity for the bladder versus other organs, and decreased intravesical pressure with minimal effects on the cardiovascular system in rats. When administered in combination with organic anion transporter (OAT) inhibitors such as probenecid (primarily used in treating gout and hyperuricemia), the plasma concentration of the active compound KUC-7322 may increase.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:20:24 GMT 2025
by
admin
on
Mon Mar 31 18:20:24 GMT 2025
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| Record UNII |
LD86RKR53M
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Preferred Name | English | ||
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Official Name | English | ||
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Common Name | English | ||
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Systematic Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C48149
Created by
admin on Mon Mar 31 18:20:24 GMT 2025 , Edited by admin on Mon Mar 31 18:20:24 GMT 2025
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| Code System | Code | Type | Description | ||
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300000034433
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9820882
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8490
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C576374
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255734-04-4
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CHEMBL2107773
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LD86RKR53M
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DTXSID50870290
Created by
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C87677
Created by
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DB12080
Created by
admin on Mon Mar 31 18:20:24 GMT 2025 , Edited by admin on Mon Mar 31 18:20:24 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
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TARGET -> AGONIST |
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| Related Record | Type | Details | ||
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PRODRUG -> METABOLITE ACTIVE |
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
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