Ficerafusp Alfa

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 06:22:24 GMT 2025` Edited by `admin` on `Wed Apr 02 06:22:24 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	chimeric-fusion\|IGG1
Sequence Origin	MOUSE CHIMERIC (CETUXIMAB), HUMAN (TGFBR2-ECD)
Sequence Type	COMPLETE
Record UNII	LZ88YF62H2
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BCA-101

Preferred Name

English

Ficerafusp Alfa

Official Name

English

Immunoglobulin G1 [de-C-terminal-lysine], anti-(human epidermal growth factor receptor) (human-Mus musculus clone BCA101 ?1-chain), disulfide with human-Mus musculus clone BCA101 ?-chain fusion protein with peptide linker (GGGGS)3 fusion protein with 23-

Common Name

English

BCA101

Code

English

chimeric immunoglobulin G1-kappa anti-(human epidermal growth factor receptor) fused at the C-terminus of both light chains, via a (G<sub>4</sub>S)<sub>3</sub> peptide linker, to a fragment of the extracellular domain of human TGF-beta receptor type-2 (T

Common Name

English

ficerafusp alfa [INN]

Common Name

English

FmAb2

Code

English

EGFR/TGF? Receptor Fusion Protein BCA101

Common Name

English

BCA 101 [WHO-DD]

Common Name

English

gamma 1 heavy chain (1-448) [VH (Mus musculus IGHV2-2*03 -(IGHD) -IGHJ3*01, CDR-Kabat [5.16.11] (31-35.50-65.98-108)) (1-119) -Homo sapiens IGHG1*08 (CH1 (120-217), hinge (218-232), CH2 (233-342), CH3 (343-447), CHS K <sup>449</sup> >del (448)) (120-448)

Common Name

English

FICERAFUSP ALFA [USAN]

Common Name

English

Code System Code Type Description

INN

12962

Created by admin on Wed Apr 02 06:22:24 GMT 2025 , Edited by admin on Wed Apr 02 06:22:24 GMT 2025

PRIMARY

FDA UNII

LZ88YF62H2

Created by admin on Wed Apr 02 06:22:24 GMT 2025 , Edited by admin on Wed Apr 02 06:22:24 GMT 2025

PRIMARY

SMS_ID

300000048066

Created by admin on Wed Apr 02 06:22:24 GMT 2025 , Edited by admin on Wed Apr 02 06:22:24 GMT 2025

PRIMARY

CAS

2764727-44-6

Created by admin on Wed Apr 02 06:22:24 GMT 2025 , Edited by admin on Wed Apr 02 06:22:24 GMT 2025

PRIMARY

USAN

KL-248

Created by admin on Wed Apr 02 06:22:24 GMT 2025 , Edited by admin on Wed Apr 02 06:22:24 GMT 2025

PRIMARY

NCI_THESAURUS

C173165

Created by admin on Wed Apr 02 06:22:24 GMT 2025 , Edited by admin on Wed Apr 02 06:22:24 GMT 2025

PRIMARY

From	To
1_22	1_95
1_146	1_202
1_222	3_214
1_228	2_228
1_231	2_231
1_263	1_323
1_369	1_427
2_22	2_95
2_146	2_202
2_222	4_214
2_263	2_323
2_369	2_427
3_23	3_88
3_134	3_194
3_258	3_261
3_268	3_274
3_278	3_284
3_291	3_308
3_328	3_343
3_345	3_350
4_23	4_88
4_134	4_194
4_258	4_261
4_268	4_274
4_278	4_284
4_291	4_308
4_328	4_343
4_345	4_350

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_88
N	1_299
N	2_88
N	2_299
N	3_277
N	3_301
N	3_361
N	4_277
N	4_301
N	4_361

Related Record Type Details


					PQX0D8J21J

Cetuximab

CONJUGATE COMPONENT->CONJUGATE

Amount:


					2Q1GS25JWN

AVOTERMIN

TARGET -> INHIBITOR

Comments:

By mopping up active TGF beta, FmAb2 inhibits TGF? signaling pathways

Amount:

Related Record Type Details


					LZ88YF62H2

Ficerafusp Alfa

ACTIVE MOIETY

Comments:

advanced/metastatic malignancies including colorectal cancer

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER AVERAGE	CHEMICAL
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL