ETHYLMORPHINE HYDROCHLORIDE

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H23NO3.ClH
Molecular Weight	349.852
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ETHYLMORPHINE HYDROCHLORIDE

Structure Search

SMILES

Cl.CCOC1=C2O[C@H]3[C@@H](O)C=C[C@H]4[C@H]5CC(C=C1)=C2[C@@]34CCN5C

InChI

InChIKey=ZPPBASOODYCKDP-YZZSNFJZSA-N

InChI=1S/C19H23NO3.ClH/c1-3-22-15-7-4-11-10-13-12-5-6-14(21)18-19(12,8-9-20(13)2)16(11)17(15)23-18;/h4-7,12-14,18,21H,3,8-10H2,1-2H3;1H/t12-,13+,14-,18-,19-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C19H23NO3
Molecular Weight	313.3908
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.bepharbel.com/uploads/produits_rcp/4yo9nqr3lf_be-spc-en-codethyline-clean.pdf

Ethylmorphine is a derivative of morphine with analgesic and antitussive effect. It acts by activating the opioid receptors and thus has a direct influence on the CNS system. Ethylmorphine was approved in Europe for the treatment of dry cough (Codethyline, Dionine).

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Opioid receptors; mu/kappa/delta 33 Target ID: CHEMBL2095181 Sources: http://www.bepharbel.com/uploads/produits_rcp/4yo9nqr3lf_be-spc-en-codethyline-clean.pdf	Agonist 2752		345.0 nM [Ki]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cough 106 Sources: http://www.bepharbel.com/uploads/pdf/qltj3rob2v_DH_V04_INSERT-CODETHYLINE-MEDISPEHERE-FR.pdf	Primary		Approved 8583	CODETHYLINE Approved Use A cough medicine.

C_max

Value	Dose	Co-administered	Analyte	Population
1.09 μM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7654478	1.5 mg/kg bw single, oral dose: 1.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered:		ETHYLMORPHINE serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
222 μM × min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7654478	1.5 mg/kg bw single, oral dose: 1.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered:		ETHYLMORPHINE serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
1.97 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7654478	1.5 mg/kg bw single, oral dose: 1.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered:		ETHYLMORPHINE serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

Doses

Dose	Population	Adverse events
8.5 mg single, oral Dose: 8.5 mg Route: oral Route: single Dose: 8.5 mg Sources: https://pubmed.ncbi.nlm.nih.gov/20158595	healthy, 10 months Health Status: healthy Age Group: 10 months Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/20158595	Other AEs: Sedation... Other AEs: Sedation (grade 5) Sources: https://pubmed.ncbi.nlm.nih.gov/20158595
1.5 mg/kg single, oral Dose: 1.5 mg/kg Route: oral Route: single Dose: 1.5 mg/kg Sources: https://pubmed.ncbi.nlm.nih.gov/7654478	healthy, 24 years Health Status: healthy Age Group: 24 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/7654478	Other AEs: Dizziness, Drowsiness... Other AEs: Dizziness (7 patients) Drowsiness (slight, 2 patients) Loose stools (1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/7654478

AEs

AE	Significance	Dose	Population
Sedation	grade 5	8.5 mg single, oral Dose: 8.5 mg Route: oral Route: single Dose: 8.5 mg Sources: https://pubmed.ncbi.nlm.nih.gov/20158595	healthy, 10 months Health Status: healthy Age Group: 10 months Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/20158595
Loose stools	1 patient	1.5 mg/kg single, oral Dose: 1.5 mg/kg Route: oral Route: single Dose: 1.5 mg/kg Sources: https://pubmed.ncbi.nlm.nih.gov/7654478	healthy, 24 years Health Status: healthy Age Group: 24 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/7654478
Dizziness	7 patients	1.5 mg/kg single, oral Dose: 1.5 mg/kg Route: oral Route: single Dose: 1.5 mg/kg Sources: https://pubmed.ncbi.nlm.nih.gov/7654478	healthy, 24 years Health Status: healthy Age Group: 24 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/7654478
Drowsiness	slight, 2 patients	1.5 mg/kg single, oral Dose: 1.5 mg/kg Route: oral Route: single Dose: 1.5 mg/kg Sources: https://pubmed.ncbi.nlm.nih.gov/7654478	healthy, 24 years Health Status: healthy Age Group: 24 years Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/7654478

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1946		substrate 1388

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
CYP2D6 1388	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/7756104/ \| https://pubmed.ncbi.nlm.nih.gov/7654478/	yes
CYP3A4 1946	substrate 4014 Sources: https://pubmed.ncbi.nlm.nih.gov/7756104/	yes

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1Q37UW
Ambinter	Amb22801513	http://www.ambinter.com/reference/22801513
Angene	AGN-PC-0OHUE6
Aurora Fine Chemicals LLC	A17.879.672	http://online.aurorafinechemicals.com/info?ID=A17.879.672
Chemieliva Pharmaceutical Co., Ltd	PBCM1411510
ChemMol	99147254	http://www.chemmol.com/chemmol/99147254.html
Compound Cloud	23724836
Compound Cloud	5359271
Debye Scientific	DB-056088
eMolecules	193735204
Glentham Life Sciences	GP3600	http://www.glentham.com/products/product/GP3600/
LGC Standards	LGCAMP0799.07-01	https://www.lgcstandards.com/US/en/p/LGCAMP0799.07-01
LGC Standards	LGCFOR0799.07	https://www.lgcstandards.com/US/en/p/LGCFOR0799.07
LGC Standards	MM0799.07	https://www.lgcstandards.com/US/en/p/MM0799.07
NovoSeek	5359271
Sigma-Aldrich	E-052_CERILLIAN	https://www.sigmaaldrich.com/catalog/product/cerillian/e052?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	E8512_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/e8512?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma Aldrich	E-052
Sigma Aldrich	E8512
Sigma Aldrich	E8512\|SIGMA
Smolecule	S620625	https://www.smolecule.com/products/s620625
Tetrahedron	TS61083
ZINC	ZINC000003629718	http://zinc15.docking.org/substances/ZINC000003629718

PubMed

Title	Date	PubMed
Characterization of xenobiotic metabolizing enzymes in bovine small intestinal mucosa.	2010-06-01	20557447
Bovine liver slices combined with an androgen transcriptional activation assay: an in-vitro model to study the metabolism and bioactivity of steroids.	2010-05	20237917
Death of a 10-month-old boy after exposure to ethylmorphine.	2010-03-01	20158595
Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats.	2010-03	21217867
[The effect of warfarin was potentiated by an antitussive. Cocillana-Etyfin increased the PK(INR) value].	2009-12-17	19998819
[Pharmacological treatment of acute cough].	2009-05-14	19448753
Importance of using highly pure internal standards for successful liquid chromatography/tandem mass spectrometric bioanalytical assays.	2009-05	19308966
Simultaneous screening and quantification of 25 opioid drugs in post-mortem blood and urine by liquid chromatography-tandem mass spectrometry.	2009-04-15	19232849
Determination of opiates and cocaine in urine by high pH mobile phase reversed phase UPLC-MS/MS.	2009-02-01	19144579
Purification of CYP2B-like protein from feral leaping mullet (Liza saliens) liver microsomes and its biocatalytic, molecular, and immunological characterization.	2008-08-30	18752317
Inhibitory effects of opioids on compound action potentials in frog sciatic nerves and their chemical structures.	2008-08-01	18593589
Determining plasma morphine levels using GC-MS after solid phase extraction to monitor drug levels in the postoperative period.	2008-06	18568238
Error in the article: "driving under the influence of opiates: concentration relationships between morphine, codeine, 6-acetyl morphine, and ethyl morphine in blood".	2008-06	18544226
Driving under the influence of opiates: concentration relationships between morphine, codeine, 6-acetyl morphine, and ethyl morphine in blood.	2008-05	18430293
[Study of cytotoxic and antiviral effects of some eye drops].	2008	19354165
A hybrid FIA/HPLC system incorporating monolithic column chromatography.	2007-09-26	17903475
Validation of direct injection electrospray LC-MS/MS for confirmation of opiates in urine drug testing.	2007-07	17535017
Electrospray LC-MS method with solid-phase extraction for accurate determination of morphine-, codeine-, and ethylmorphine-glucuronides and 6-acetylmorphine in urine.	2007-03	17536742
[Current problems in the quality control of pharmaceutical preparations manufactured in pharmacies II. Paracetamol contraining preparations].	2006	17575797
Automated multiple development thin-layer chromatography for separation of opiate alkaloids and derivatives.	2005-07-08	16008057
Validated toxicological determination of 30 drugs of abuse as optimized derivatives in oral fluid by long column fast gas chromatography/electron impact mass spectrometry.	2005-06	15806585
Inhibition of rat liver CYP2D in vitro and after 1-day and long-term exposure to neuroleptics in vivo-possible involvement of different mechanisms.	2005-01	15572279
Screening for drugs of abuse in hair with ion spray LC-MS-MS.	2004-10-29	15451091
Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids.	2004-09-15	15364545
Evaluation of the One-Step ELISA kit for the detection of buprenorphine in urine, blood, and hair specimens.	2004-07-16	15240036
Biochemical background of toxic interaction between tiamulin and monensin.	2004-03-15	15013817
Interpretation of the presence of 6-monoacetylmorphine in the absence of morphine-3-glucuronide in urine samples: evidence of heroin abuse.	2003-10	14508389
Genomic characterization and regulation of CYP3a13: role of xenobiotics and nuclear receptors.	2003-09	12958193
Enzyme immunoassay validation for the detection of buprenorphine in urine.	2003-03	12670004
Evidence for the presence of active cytochrome P450 systems in Schistosoma mansoni and Schistosoma haematobium adult worms.	2002-05-22	12023046
Simultaneous determination of codeine and ethyl morphine HCL in tablet formulations using LC.	2001-08	11451638
[Experimental study on using diclofenac sodium or dionine topically to treat fibrinous membrane after intraocular lens implantation].	2001-06-28	12536684
Effects of fumonisin B1 present in Fusarium moniliforme culture material on drug metabolising enzyme activities in ducks.	2001-05-19	11369472
[Effects of diclofenac sodium combined with dionine in cases with fibrinous membrane after intraocular lens implantation].	2001-04-28	12536644
Effects of ethanol on ethylmorphine metabolism in isolated rat hepatocytes: characterization by means of a multicompartmental model.	1997-04	9140136
Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose.	1995-06	7654478
Acute renal failure due to concomitant action of methotrexate and indomethacin.	1986-06-14	2872506

Patents

Sample Use Guides

In Vivo Use Guide

The recommended dose in adults is 50 mg of codethyline per day, i.e. 10 tablets (1 tablet contains 5 mg of ethylmorphine hydrochloride) per day over several intakes, at a minimum of 4 hours apart. In children the normal dose is 1 tablet per intake, to be renewed after 6 hours if necessary, without exceeding 4 tablets per day.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:11:26 GMT 2025` Edited by `admin` on `Mon Mar 31 18:11:26 GMT 2025`
Record UNII	MFM5450P3T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ETHYLMORPHINE HYDROCHLORIDE

Common Name

English

CODETHYLINE HYDROCHLORIDE

Preferred Name

English

Ethylmorphine hydrochloride [WHO-DD]

Common Name

English

ETHYLMORPHINE HCL

Common Name

English

(5.ALPHA.,6.ALPHA.)-7,8-DIDEHYDRO-4,5-EPOXY-3-ETHOXY-17-METHYLMORPHINAN-6-OL HYDROCHLORIDE

Systematic Name

English

ETHYLMORPHINE HYDROCHLORIDE ANHYDROUS [MI]

Common Name

English

ETHYLMORPHINE HYDROCHLORIDE [EP MONOGRAPH]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C67413