MORPHINE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H19NO3
Molecular Weight	285.3377
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MORPHINE

Structure Search

SMILES

[H][C@@]12OC3=C(O)C=CC4=C3[C@@]15CCN(C)[C@]([H])(C4)[C@]5([H])C=C[C@@H]2O

InChI

InChIKey=BQJCRHHNABKAKU-KBQPJGBKSA-N

InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C17H19NO3
Molecular Weight	285.3377
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:35:43 UTC 2023` Edited by `admin` on `Fri Dec 15 16:35:43 UTC 2023`
Record UNII	76I7G6D29C
Record Status	`Validated (UNII)`
Record Version

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Related Record	Type

Name

Type

Language

MORPHINE

Common Name

English

NEPENTHE

Common Name

English

CODEINE PHOSPHATE SESQUIHYDRATE IMPURITY B [EP IMPURITY]

Common Name

English

CODEINE MONOHYDRATE IMPURITY B [EP IMPURITY]

Common Name

English

HYDROCODONE HYDROGEN TARTRATE 2.5-HYDRATE IMPURITY A [EP IMPURITY]

Common Name

English

MORPHIUM

Common Name

English

MORPHINE [MART.]

Common Name

English

DIHYDROCODEINE HYDROGEN TARTRATE IMPURITY B [EP IMPURITY]

Common Name

English

MORPHINAN-3,6-DIOL, 7,8-DIDEHYDRO-4,5-EPOXY-17-METHYL, (5.ALPHA.,6.ALPHA.)-

Common Name

English

MORPHINE [VANDF]

Common Name

English

MORPHIA

Common Name

English

DUROMORPH

Common Name

English

ANHYDROUS MORPHINE

Common Name

English

MORPHINE [HSDB]

Common Name

English

MORPHINE EXTENDED RELEASE

Common Name

English

OSPALIVINA

Common Name

English

MORPHINE [MI]

Common Name

English

N02AA01

Code

English

4,5.ALPHA.-EPOXY-17-METHYL-7,8-DIDEHYDROMORPHINAN-3,6.ALPHA.-DIO

Systematic Name

English

(5.ALPHA.,6.ALPHA.)-7,8-DIDEHYDRO-4,5-EPOXY-17-METHYLMORPHINAN-3,6-DIOL

Systematic Name

English

7,8-DIDEHYDRO-4,5.ALPHA.-EPOXY-17-METHYLMORPHINAN-3,6.ALPHA.-DIOL

Systematic Name

English

APOMORPHINE HYDROCHLORIDE HEMIHYDRATE IMPURITY B [EP IMPURITY]

Common Name

English

HYDROMORPHONE HYDROCHLORIDE IMPURITY, MORPHINE- [USP IMPURITY]

Common Name

English

7,8-didehydro-4,5α-epoxy-17-methylmorphinan-3,6α-diol

Systematic Name

English

CODEINE PHOSPHATE HEMIHYDRATE IMPURITY B [EP IMPURITY]

Common Name

English

CODEINE HYDROCHLORIDE DIHYDRATE IMPURITY B [EP IMPURITY]

Common Name

English

MORPHINE (ANHYDROUS) [VANDF]

Common Name

English

Morphine [WHO-DD]

Common Name

English

ETHYLMORPHINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]

Common Name

English

IDS-NM-009

Code

English

HYDROMORPHONE HYDROCHLORIDE IMPURITY C [EP IMPURITY]

Common Name

English

MORPHINE (ANHYDROUS)

Common Name

English

MORPHINE ANHYDROUS

Common Name

English

Classification Tree Code System Code

WHO-ESSENTIAL MEDICINES LIST

8.4

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

CFR

21 CFR 862.3640

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

WHO-ATC

N02AA51

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

WHO-VATC

QN02AA01

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

DEA NO.

9300

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

NDF-RT

N0000175684

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

LIVERTOX

NBK548230

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

WHO-VATC

QA07DA52

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

NDF-RT

N0000175690

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

2.2

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

1.3

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

WHO-VATC

QN02AA51

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

WHO-VATC

QN02AG01

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

WHO-ATC

N02AA01

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

WHO-VATC

QR05DA05

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

WHO-ATC

N02AG01

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

WHO-ATC

R05DA05

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

NCI_THESAURUS

C1657

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

WHO-ATC

A07DA52

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

Code System Code Type Description

ChEMBL

CHEMBL70

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

IUPHAR

1627

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

HSDB

2134

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

MESH

D009020

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

DRUG CENTRAL

1845

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

DRUG BANK

DB00295

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

NCI_THESAURUS

C62051

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

EVMPD

SUB03332MIG

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

RXCUI

7052

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

RxNorm

ECHA (EC/EINECS)

200-320-2

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

CAS

57-27-2

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

MERCK INDEX

m7631

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

Merck Index

LACTMED

Morphine

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

SMS_ID

100000091372

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

PUBCHEM

5288826

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

CHEBI

58097

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

CHEBI

17303

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

EVMPD

SUB121757

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

EPA CompTox

DTXSID9023336

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

WIKIPEDIA

MORPHINE

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

FDA UNII

76I7G6D29C

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

DAILYMED

76I7G6D29C

Created by admin on Fri Dec 15 16:35:45 UTC 2023 , Edited by admin on Fri Dec 15 16:35:45 UTC 2023

PRIMARY

Related Record Type Details


					2BJ58BX78W

KAPPA-TYPE OPIOID RECEPTOR

TARGET -> AGONIST

Qualification:

Ki

Amount:


					7OP86J5E33

DERIVATIVE -> PARENT

Comments:

Dihydrodesoxymorphine (derivative of morphine). as per INCB


					3GZ4H1UV4X

MORPHINE OLEATE

SALT/SOLVATE -> PARENT

Amount:

MORPHINE POLISTIREX

SUB_CONCEPT->SUBSTANCE

Amount:


					51VG588F9Q

MORPHINE METHYLSULFONATE

SALT/SOLVATE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:


					87LP9D5J54

MORPHINE HYDROBROMIDE DIHYDRATE

SALT/SOLVATE -> PARENT

Amount:


					J28GE0ROVX

MORPHINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:


					1LQ9207LZE

MORPHINE PHOSPHATE

SALT/SOLVATE -> PARENT

Amount:


					ARKJBVK150

MORPHINE 6-.BETA.-D-GLUCURONIDE DIHYDRATE

DERIVATIVE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:


					DV2P23JCWV

MORPHINE NITRATE

SALT/SOLVATE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:


					DY70C97N30

MORPHINE SULFATE ANHYDROUS

SALT/SOLVATE -> PARENT

Amount:


					6VF5938F7R

MORPHINE 3-PROPIONYL

DERIVATIVE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:


					U3NSU23LHD

MORPHINE TARTRATE

SALT/SOLVATE -> PARENT

Amount:


					D74B54D2RE

MORPHINE METHYLCHLORIDE

DERIVATIVE -> PARENT

Amount:


					X3P646A2J0

MORPHINE SULFATE

SALT/SOLVATE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:


					OQ24I15UTV

MORPHINE 3-HEMISUCCINATE

DERIVATIVE -> PARENT

Amount:


					1PE72K8X46

MU-TYPE OPIOID RECEPTOR

TARGET -> AGONIST

Qualification:

Ki

Amount:


					JT5I2F57F7

CODOXIME

DERIVATIVE -> PARENT

Comments:

Dihydrocodeinone-6-carboxymethyloxime (derivate of morphine). as per INCB


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE


					O8N049CFE1

MORPHINE 6-HEMISUCCINATE

DERIVATIVE -> PARENT

Amount:


					TRM5Y4BN2D

MORPHINE PHENYLPROPIONATE

DERIVATIVE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:


					X1W88415WG

MORPHINE HYDROBROMIDE

SALT/SOLVATE -> PARENT

Amount:


					41TQ665R1X

MORPHINE MONOHYDRATE

SOLVATE->ANHYDROUS

Amount:


					XHJ8VJ6QDS

MORPHINE PHOSPHATE HEMIHYDRATE

SALT/SOLVATE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:


					806E27L76Z

MORPHINE HYDRIODIDE

SALT/SOLVATE -> PARENT

Amount:


					S7I4VJV00U

MORPHINE HYPOPHOSPHITE

SALT/SOLVATE -> PARENT

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Amount:


					0G2SR6TT4X

MORPHINE HYDRIODIDE DIHYDRATE

SALT/SOLVATE -> PARENT

Amount:


					Q5F3AS69LF

MORPHINE HYDROCHLORIDE TRIHYDRATE

SALT/SOLVATE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:


					41TQ665R1X

MORPHINE MONOHYDRATE

SALT/SOLVATE -> PARENT

Amount:


					VEO43W5229

MORPHINE ACETATE

SALT/SOLVATE -> PARENT

Amount:


					EV0PWK6TT6

DELTA-TYPE OPIOID RECEPTOR

TARGET -> AGONIST

Qualification:

Ki

Amount:


					D74B54D2RE

MORPHINE METHYLCHLORIDE

PARENT -> SALT/SOLVATE

Amount:


					9N7243EY5T

3-MONOACETYLMORPHINE

DERIVATIVE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:

Related Record Type Details


					O27Z9CH39A

MORPHINE-3-GLUCURONIDE

METABOLITE INACTIVE -> PARENT

Interaction Type:

MAJOR

Amount:


					UX6OWY2V7J

CODEINE ANHYDROUS

PRODRUG -> METABOLITE ACTIVE

Comments:

MINOR METABOLITE

Interaction Type:

MINOR


					O27Z9CH39A

MORPHINE-3-GLUCURONIDE

METABOLITE INACTIVE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:


					70D95007SX

PRODRUG -> METABOLITE ACTIVE

Amount:


					64Y9KYM60R

MORPHINE-6-GLUCURONIDE

METABOLITE ACTIVE -> PARENT

Interaction Type:

MAJOR

Amount:

Related Record Type Details


					F39049Y068

APOMORPHINE HYDROCHLORIDE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					BKA0632GWS

CODEINE PHOSPHATE SESQUIHYDRATE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					Q830PW7520

CODEINE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					L960UP2KRW

HYDROMORPHONE HYDROCHLORIDE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					GSL05Y1MN6

CODEINE PHOSPHATE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					MFM5450P3T

ETHYLMORPHINE HYDROCHLORIDE

PARENT -> IMPURITY

Amount:


					NO70W886KK

HYDROCODONE BITARTRATE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					8LXS95BSA9

DIHYDROCODEINE BITARTRATE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					NTZ53GG7XN

CODEINE HYDROCHLORIDE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					407X3NQV4N

ETHYLMORPHINE HYDROCHLORIDE DIHYDRATE

PARENT -> IMPURITY

Amount:

Related Record Type Details


					76I7G6D29C

MORPHINE

ACTIVE MOIETY

Comments:

ED50-PO(mg/kg) = 0.33, LD50-PO(mg/kg) = 470, Potency ratio to morphine = 1, Potency ratio to fentanyl = 0.02

Amount: