U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C18H21NO3
Molecular Weight 299.3642
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CODEINE ANHYDROUS

SMILES

COC1=C2O[C@H]3[C@@H](O)C=C[C@H]4[C@H]5CC(C=C1)=C2[C@@]34CCN5C

InChI

InChIKey=OROGSEYTTFOCAN-DNJOTXNNSA-N
InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1

HIDE SMILES / InChI
Molecular Formula C18H21NO3
Molecular Weight 299.3642
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 5 / 5
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Codeine is an opiate used to manage mild to moderate pain severe enough to require an opioid. Codeine is a selective agonist for the mu opioid receptor and has an affinity to delta and kappa-opioid receptors. In some countries, this drug is regulated under various narcotic control laws, because its chronic use can cause physical dependence. In others, it is available without a medical prescription in combination with paracetamol.

CNS Activity

Approval Year

1921
1468
Targets

Targets

Primary TargetPharmacologyConditionPotency
Agonist
2752
 6.1 µM [EC50]
Kappa-type opioid receptor
61
Target ID: P41145
Gene ID: 4986.0
Gene Symbol: OPRK1
Target Organism: Homo sapiens (Human)
Agonist
2752
Delta-type opioid receptor
46
Target ID: P41143
Gene ID: 4985.0
Gene Symbol: OPRD1
Target Organism: Homo sapiens (Human)
Agonist
2752
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8583
CAPITAL AND CODEINE

Approved Use

Unknown
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
66.9 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/1391681/
30 mg single, oral
dose: 30 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CODEINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
145 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/7094509/
60 mg single, oral
dose: 60 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CODEINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
229 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/7094509/
60 mg single, intramuscular
dose: 60 mg
route of administration: Intramuscular
experiment type: SINGLE
co-administered:
CODEINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
93 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/7094509/
60 mg single, oral
dose: 60 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CODEINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
242 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/7094509/
60 mg single, intramuscular
dose: 60 mg
route of administration: Intramuscular
experiment type: SINGLE
co-administered:
CODEINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
53.5 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/1391681/
30 mg single, oral
dose: 30 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
MORPHINE-3-GLUCURONIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
66.9 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/1391681/
30 mg single, oral
dose: 30 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CODEINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
968 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/1391681/
30 mg single, oral
dose: 30 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CODEINE-6-GLUCURONIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
0.61 μM × h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/1391681/
30 mg single, oral
dose: 30 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CODEINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
466 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/7094509/
60 mg single, oral
dose: 60 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CODEINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
849 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/7094509/
60 mg single, intramuscular
dose: 60 mg
route of administration: Intramuscular
experiment type: SINGLE
co-administered:
CODEINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
467 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/7094509/
60 mg single, oral
dose: 60 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CODEINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
937 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/7094509/
60 mg single, intramuscular
dose: 60 mg
route of administration: Intramuscular
experiment type: SINGLE
co-administered:
CODEINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
1.47 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/1391681/
30 mg single, oral
dose: 30 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CODEINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
2.8 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/7094509/
60 mg single, oral
dose: 60 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CODEINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
2.8 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/7094509/
60 mg single, intramuscular
dose: 60 mg
route of administration: Intramuscular
experiment type: SINGLE
co-administered:
CODEINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
2.7 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/7094509/
60 mg single, oral
dose: 60 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CODEINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
2.9 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/7094509/
60 mg single, intramuscular
dose: 60 mg
route of administration: Intramuscular
experiment type: SINGLE
co-administered:
CODEINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
1.71 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/1391681/
30 mg single, oral
dose: 30 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
MORPHINE-3-GLUCURONIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
1.47 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/1391681/
30 mg single, oral
dose: 30 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CODEINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
2.75 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/1391681/
30 mg single, oral
dose: 30 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CODEINE-6-GLUCURONIDE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
75%
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022402s000lbl.pdf
15 mg single, oral
dose: 15 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CODEINE plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
360 mg 1 times / day multiple, oral
Highest recorded dose
Dose: 360 mg, 1 times / day
Route: oral
Route: multiple
Dose: 360 mg, 1 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022402s000lbl.pdf
unhealthy
Health Status: unhealthy
Sex: M+F
Food Status: UNKNOWN
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022402s000lbl.pdf
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022402s000lbl.pdf
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
substrate
1946

inhibitor
2252
inhibitor
2438
substrate
1388

inhibitor
2507
inhibitor
2217

OverviewOther

Other InhibitorOther SubstrateOther Inducer
OCT1
620

UGT2B7
197

CYP19A1
429

CYP1A2
2153
UGT2B7
456

UGT1A3
470

UGT1A1
479

UGT1A4
399

OCT1
393

UGT2B4
278

UGT1A8
323

UGT1A10
331

P-gp
2052

UGT2B15
236
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
CYP2D6
2546
 inconclusive [IC50 35.7774 uM]
CYP19A1
430
 no
CYP1A2
2333
 no
CYP2C9
2497
 no
CYP3A4
2633
 no
UGT2B7
210
 unlikely [IC50 400 uM]
OCT1
656
 yes [IC50 10.5 uM]
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
UGT2B4
278
 major
UGT2B7
456
 major
P-gp
2052
 no
UGT1A10
331
 no
UGT1A3
470
 no
UGT1A4
399
 no
UGT1A8
323
 no
UGT2B15
236
 no
CYP2D6
1388
 yes
CYP3A4
1946
 yes
OCT1
393
 yes
UGT1A1
479
 yes
Morphine
12
UGT2B7
456
 yes
Morphine
12
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
hERG
2263
Sourcing

Sourcing

Vendor/AggregatorIDURL
ABI Chem
AC1Q4DTD
Alfa Chemistry
170301
Alfa Chemistry
ACM52453040
AN PharmaTech
AN-23899
Angene
AGN-PC-0U9ZUU
Aurora Fine Chemicals LLC
A17.876.233
http://online.aurorafinechemicals.com/info?ID=A17.876.233
Avantor Inc
75835-236
https://us.vwr.com/store/product/21998648/exempted-drug-of-abuse-reference-standards-restek
Changzhou Highassay Chemical Co., Ltd
my_sub1415
Chemieliva Pharmaceutical Co., Ltd
PBCM0821173
ChemMol
30101025
http://www.chemmol.com/chemmol/30101025.html
ChemMol
49416695
http://www.chemmol.com/chemmol/49416695.html
ChemMol
99138769
http://www.chemmol.com/chemmol/99138769.html
Clearsynth
CS-T-56966
http://www.clearsynth.com/en/CST56966.html
Compound Cloud
21155870
Compound Cloud
24892867
Compound Cloud
5284371
Compound Cloud
5362471
Compound Cloud
6321303
eMolecules
193733897
Hangzhou APIChem Technology
AC-11114
HongKong Chemhere
SCA54117
IBScreen
BB_NC-00138
IBScreen
STOCK1N-42851
LGC Standards
LGCAMP0004.10-01
https://www.lgcstandards.com/US/en/p/LGCAMP0004.10-01
LGC Standards
LGCAMP0004.10-02
https://www.lgcstandards.com/US/en/p/LGCAMP0004.10-02
LGC Standards
LGCFOR0004.10
https://www.lgcstandards.com/US/en/p/LGCFOR0004.10
LGC Standards
MM0004.10
https://www.lgcstandards.com/US/en/p/MM0004.10
mcule
MCULE-4129237460
mcule
MCULE-6243921692
Parchem
87121
https://www.parchem.com/chemical-supplier-distributor/Codeine-Alkaloid-087121.aspx
Parchem
87123
https://www.parchem.com/chemical-supplier-distributor/Codeine-USP-087123.aspx
Sigma-Aldrich
C-006_CERILLIAN
https://www.sigmaaldrich.com/catalog/product/cerillian/c006?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
C1653_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/c1653?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
Y0000722_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/y0000722?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma Aldrich
C1653|SIAL
Sigma Aldrich
C3539|SIAL
Sigma Aldrich
C5901|SIAL
Sigma Aldrich
Y0000722
Sigma Aldrich
Y0000722|SIAL
Smolecule
S627560
https://www.smolecule.com/products/s627560
Tetrahedron
TS63993
Tetrahedron
TS80953
Toronto Research Chemicals
C634075
Toronto Research Chemicals
C634080
Toronto Research Chemicals
KIT0410
Toronto Research Chemicals
KIT2460
Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd.
PH-1498A
ZINC
ZINC000003806721
http://zinc15.docking.org/substances/ZINC000003806721
PubMed

PubMed

TitleDatePubMed
LC method for the analysis of paracetamol, caffeine and codeine phosphate in pharmaceutical preparations.
2001-12
The role of adrenal corticosteroids in induction of micronuclei by morphine.
2001-11-15
Nutritional effects of surgical and medical treatment for short bowel syndrome.
2001-11-02
Scalp nerve blocks decrease the severity of pain after craniotomy.
2001-11
Concentration ratios of morphine to codeine in blood of impaired drivers as evidence of heroin use and not medication with codeine.
2001-11
Endogenous morphine and codeine. Possible role as endogenous anticonvulsants.
2001-10-12
Drug contamination of US paper currency.
2001-10-01
Predictors for completing an inpatient detoxification program among intravenous heroin users, methadone substituted and codeine substituted patients.
2001-10-01
Novel dynamic polymer coating for capillary electrophoresis in nonaqueous methanolic background electrolytes.
2001-10
Seizures with intravenous codeine phosphate.
2001-10
Incorporation of selegiline metabolites into hair after oral selegiline intake.
2001-10
Analysis of morphine and codeine in samples adulterated with Stealth.
2001-10
Detection of opiate use in a methadone maintenance treatment population with the CEDIA 6-acetylmorphine and CEDIA DAU opiate assays.
2001-10
Ropivacaine with or without clonidine improves pediatric tonsillectomy pain.
2001-10
Experience with urine drug testing by the Correctional Service of Canada.
2001-09-15
Spontaneous reports on drug-induced pancreatitis in Denmark from 1968 to 1999.
2001-09
Community pharmacists' experience of over-the-counter medicine misuse in Scotland.
2001-09
Cetirizine inhibits skin reactions but not mediator release in immediate and developing late-phase allergic cutaneous reactions. A double-blind, placebo-controlled study.
2001-09
Rofecoxib versus codeine/acetaminophen in postoperative dental pain: a double-blind, randomized, placebo- and active comparator-controlled clinical trial.
2001-09
Tramadol/acetaminophen combination tablets and codeine/acetaminophen combination capsules for the management of chronic pain: a comparative trial.
2001-09
Blind trials of an onsite saliva drug test for marijuana and opiates.
2001-09
[Weak opioids].
2001-09
[Strong opioids].
2001-09
Concentration ratios of codeine-to-morphine in plasma after a single oral dose (100 mg) of codeine phosphate.
2001-09
Detection of non-prescription heroin markers in urine with liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.
2001-09
Pain control in medical abortion.
2001-09
Engineering novel biocatalytic routes for production of semisynthetic opiate drugs.
2001-09
Can standard open pediatric urological procedures be performed on an outpatient basis?
2001-09
Precipitated withdrawal following codeine administration is dependent on CYP genotype.
2001-08-17
From codeine to transdermal fentanyl for cancer pain control: a safety and efficacy clinical trial.
2001-08-15
Heroin use by motorists in Sweden confirmed by analysis of 6-acetylmorphine in urine.
2001-08-14
Laboratory analysis of remotely collected oral fluid specimens for opiates by immunoassay.
2001-08-14
Prescribing limitations.
2001-08-11
[Paracetamol-codeine induced hepatic colic].
2001-08-02
Randomized placebo controlled trial of lofexidine hydrochloride for chronic pelvic pain in women.
2001-08
Simultaneous determination of codeine and ethyl morphine HCL in tablet formulations using LC.
2001-08
Sticky business: patterns of procurement and misuse of prescription cough syrup in Houston.
2001-07-31
Head-column field-amplified sample stacking in presence of siphoning. Application to capillary electrophoresis-electrospray ionization mass spectrometry of opioids in urine.
2001-07-27
Use of beta-cyclodextrin in the capillary zone electrophoretic separation of the components of clandestine heroin preparations.
2001-07-27
Opiate-sensitivity: clinical characteristics and the role of skin prick testing.
2001-07
Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK-PD modelling analysis.
2001-07
[Information on preparations containing codeine].
2001-06-20
[Chronic pain in geriatrics].
2001-06
Effect of apical trephination on postoperative pain and swelling in symptomatic necrotic teeth.
2001-06
Codeine phosphate in paediatric medicine.
2001-03
Codeine phosphate in children: time for re-evaluation?
2001-03
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
2001-02
Effect of prophylactic amoxicillin on endodontic flare-up in asymptomatic, necrotic teeth.
2001-01
Over-the-counter medications for acute cough in children and adults in ambulatory settings.
2001
Dystonia as acute adverse reaction to cough suppressant in a 3-year-old girl.
2001
Patents

Patents

05869669
14
08337890
16
08710069
12
08790700
16
JP2002104963A
12
JP2002511777A
420
JP2006520379A
75
JP2009520033A
20
JP2011507842A
17
JP4804361B2
32
JPH00286794A
24
JPS5323998A
14
JPS572288A
16

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:29:42 GMT 2025
Edited
by admin
on Mon Mar 31 18:29:42 GMT 2025
Record UNII
UX6OWY2V7J
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
IDS-NC-005(SECT.-2)
Preferred Name English
CODEINE ANHYDROUS
Common Name English
MYTUSSIN
Common Name English
ETHYLMORPHINE HYDROCHLORIDE IMPURITY C [EP IMPURITY]
Common Name English
CODEINE [HSDB]
Common Name English
CODEINE [MI]
Common Name English
SS85U8K5ZN
Common Name English
KODELAK FITO
Common Name English
MORPHINE MONOMETHYL ETHER
Common Name English
HYDROCODONE HYDROGEN TARTRATE 2.5-HYDRATE IMPURITY C [EP IMPURITY]
Common Name English
7,8-didehydro-4,5?-epoxy-3-methoxy-17-methylmorphinan-6?-ol
Systematic Name English
O3-METHYLMORPHINE
Common Name English
CODICEPT
Common Name English
DIHYDROCODEINE HYDROGEN TARTRATE IMPURITY A [EP IMPURITY]
Common Name English
Codeine [WHO-DD]
Common Name English
METHYLMORPHINE
Common Name English
CODUCEPT
Common Name English
MORPHINAN-6-OL, 7,8-DIDEHYDRO-4,5-EPOXY-3-METHOXY-17-METHYL-, (5.ALPHA.,6.ALPHA.)-
Systematic Name English
MORPHINE SULFATE IMPURITY A [EP IMPURITY]
Common Name English
MORPHINE HYDROCHLORIDE IMPURITY A [EP IMPURITY]
Common Name English
Classification Tree Code System Code
NDF-RT N0000175690
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
NDF-RT N0000175684
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
CFR 21 CFR 862.3270
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
DEA NO. 9050
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
WHO-ATC N02AJ09
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
Code System Code Type Description
DRUG BANK
DB00318
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
PRIMARY
SMS_ID
100000079790
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
PRIMARY
CAS
76-57-3
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
PRIMARY
NCI_THESAURUS
C171855
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
ALTERNATIVE
ECHA (EC/EINECS)
200-969-1
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
PRIMARY
PUBCHEM
5284371
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
PRIMARY
MERCK INDEX
m3718
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
PRIMARY Merck Index
NCI_THESAURUS
C77284
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
PRIMARY
CHEBI
16714
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
PRIMARY
EPA CompTox
DTXSID2020341
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
PRIMARY
LEGACY_FDA_UNII
SS85U8K5ZN
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
PRIMARY
DAILYMED
UX6OWY2V7J
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
PRIMARY
RXCUI
236131
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
ALTERNATIVE
RXCUI
1545976
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
PRIMARY
HSDB
3043
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
PRIMARY
EVMPD
SUB127261
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
PRIMARY
EVMPD
SUB13424MIG
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
PRIMARY
FDA UNII
UX6OWY2V7J
Created by admin on Mon Mar 31 18:29:42 GMT 2025 , Edited by admin on Mon Mar 31 18:29:42 GMT 2025
PRIMARY
Related Record Type Details
Structure of CODEINE HYDROBROMIDE
SALT/SOLVATE -> PARENT
Structure of CODEINE PHOSPHATE ANHYDROUS
SALT/SOLVATE -> PARENT
Structure of CODEINE SULFATE
SALT/SOLVATE -> PARENT
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
Structure of CODEINE PHOSPHATE
SALT/SOLVATE -> PARENT
Structure of CODEINE
SOLVATE->ANHYDROUS
Structure of CODEINE SULFATE ANHYDROUS
SALT/SOLVATE -> PARENT
Structure of CODEINE METHYL BROMIDE
SALT/SOLVATE -> PARENT
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B4
METABOLIC ENZYME -> SUBSTRATE
CODEINE POLISTIREX
SUB_CONCEPT->SUBSTANCE
Structure of CODEINE
SALT/SOLVATE -> PARENT
Structure of CODEINE PHOSPHATE SESQUIHYDRATE
SALT/SOLVATE -> PARENT
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B7
METABOLIC ENZYME -> SUBSTRATE
Structure of CODEINE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
CYTOCHROME P450 2D6
METABOLIC ENZYME -> SUBSTRATE
Related Record Type Details
Structure of CODEINONE
METABOLITE -> PARENT
Structure of NORCODEINE
METABOLITE INACTIVE -> PARENT
Metabolic Enzyme - cytochrome P-450 3A4
Structure of CODEINE-6-GLUCURONIDE
METABOLITE ACTIVE -> PRODRUG
MAJOR METABOLITE MAY BE RESPONSIBLE FOR ANALGESIC EFFECT
MAJOR
Structure of MORPHINE
METABOLITE ACTIVE -> PRODRUG
MINOR METABOLITE
MINOR
Related Record Type Details
Structure of ETHYLMORPHINE HYDROCHLORIDE
PARENT -> IMPURITY
Structure of ETHYLMORPHINE HYDROCHLORIDE DIHYDRATE
PARENT -> IMPURITY
Structure of MORPHINE SULFATE
PARENT -> IMPURITY
Structure of DIHYDROCODEINE BITARTRATE
PARENT -> IMPURITY
Structure of HYDROCODONE BITARTRATE
PARENT -> IMPURITY
Structure of MORPHINE HYDROCHLORIDE
PARENT -> IMPURITY
Related Record Type Details
Structure of CODEINE ANHYDROUS
ACTIVE MOIETY
NIH
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