ISOCITRATE DEHYDROGENASE (NADP) CYTOPLASMIC R132C

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 01:03:16 GMT 2025` Edited by `admin` on `Wed Apr 02 01:03:16 GMT 2025`
Protein Type	ENZYME
Protein Sub Type	OXIDOREDUCTASE
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	MFS7RWZ7PI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CYTOSOLIC NADP-ISOCITRATE DEHYDROGENASE R132C

Preferred Name

English

ISOCITRATE DEHYDROGENASE (NADP) CYTOPLASMIC R132C

Common Name

English

IDH R132C MUTANT

Common Name

English

NADP(+)-SPECIFIC ICDH R132C

Common Name

English

IDH1 R132C MUTANT

Common Name

English

PICD R132C

Common Name

English

OXALOSUCCINATE DECARBOXYLASE R132C

Common Name

English

Code System Code Type Description

WIKIPEDIA

IDH1

Created by admin on Wed Apr 02 01:03:16 GMT 2025 , Edited by admin on Wed Apr 02 01:03:16 GMT 2025

PRIMARY

UNIPROT

O75874

Created by admin on Wed Apr 02 01:03:16 GMT 2025 , Edited by admin on Wed Apr 02 01:03:16 GMT 2025

PRIMARY

EC (ENZYME CLASS)

EC 1.1.1.42

Created by admin on Wed Apr 02 01:03:16 GMT 2025 , Edited by admin on Wed Apr 02 01:03:16 GMT 2025

PRIMARY

FDA UNII

MFS7RWZ7PI

Created by admin on Wed Apr 02 01:03:16 GMT 2025 , Edited by admin on Wed Apr 02 01:03:16 GMT 2025

PRIMARY

Related Record Type Details


					0T4IMT8S5Z

OLUTASIDENIB

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					Q2PCN8MAM6

IVOSIDENIB

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Fragment Name	Fragment Approval
AMINO ACID REPLACEMENT	[1_41] [2_41]		TYROSINE	TYROSINE O-PHOSPHATE	2R86C98KDX
AMINO ACID REPLACEMENT	[1_388] [2_388]		SERINE	DEXFOSFOSERINE	VI4F0K069V
METAL_BINDING	[1_251] [1_274] [1_278] [2_251] [2_274] [2_278]	SITE_SPECIFIC		MANGANOUS CATION	H6EP7W5457
AMINO ACID REPLACEMENT	[1_80] [1_223] [1_232] [1_242] [1_320] [2_80] [2_223] [2_232] [2_242] [2_320]		LYSINE	N6-ACETYLLYSINE	470AD5VY1X
AMINO ACID REPLACEMENT	[1_125] [1_399] [2_125] [2_399]		LYSINE	N6-SUCCINYLLYSINE	3LH35AJA5L
AMINO ACID REPLACEMENT	[1_1] [2_1]		SERINE	N-ACETYLSERINE	W98518XGZ3
METAL_BINDING	[1_251] [1_274] [1_278] [2_251] [2_274] [2_278]	SITE_SPECIFIC		MANGANOUS CATION	H6EP7W5457

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED)	CHEMICAL