MIRABEGRON

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H24N4O2S
Molecular Weight	396.506
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MIRABEGRON

Structure Search

SMILES

NC1=NC(CC(=O)NC2=CC=C(CCNC[C@H](O)C3=CC=CC=C3)C=C2)=CS1

InChI

InChIKey=PBAPPPCECJKMCM-IBGZPJMESA-N

InChI=1S/C21H24N4O2S/c22-21-25-18(14-28-21)12-20(27)24-17-8-6-15(7-9-17)10-11-23-13-19(26)16-4-2-1-3-5-16/h1-9,14,19,23,26H,10-13H2,(H2,22,25)(H,24,27)/t19-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H24N4O2S
Molecular Weight	396.506
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:12:55 UTC 2023` Edited by `admin` on `Fri Dec 15 16:12:55 UTC 2023`
Record UNII	MVR3JL3B2V
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MIRABEGRON

Official Name

English

MIRABEGRON [USAN]

Common Name

English

YM178

Code

English

mirabegron [INN]

Common Name

English

4-THIAZOLEACETAMIDE, 2-AMINO-N-(4-(2-(((2R)-2-HYDROXY-2-PHENYLETHYL)AMINO)ETHYL)PHENYL)-

Systematic Name

English

BETMIGA

Brand Name

English

2-(2-Aminothiazol-4-yl)-N-[4-(2-{[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)phenyl]acetamide

Systematic Name

English

YM-178

Code

English

MYRBETRIQ

Brand Name

English

MIRABEGRON [ORANGE BOOK]

Common Name

English

BETANIS

Brand Name

English

MIRABEGRON [MART.]

Common Name

English

MIRABEGRON [VANDF]

Common Name

English

MIRABEGRON [MI]

Common Name

English

MIRABEGRON [JAN]

Common Name

English

2-(2-AMINO-1,3-THIAZOL-4-YL)-N-(4-(2-(((2R)-2-HYDROXY-2-PHENYLETHYL)AMINO)ETHYL)PHENYL)ACETAMIDE

Systematic Name

English

Mirabegron [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C48149

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

LIVERTOX

NBK547887

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

NDF-RT

N0000185008

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

WHO-VATC

QG04BD12

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

WHO-ATC

G04BD12

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

EMA ASSESSMENT REPORTS

BETMIGA (AUTHORIZED: URINARY BLADDER, OVERACTIVE)

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

Code System Code Type Description

DRUG BANK

DB08893

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

INN

8907

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

PUBCHEM

9865528

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

LACTMED

Mirabegron

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

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WIKIPEDIA

Mirabegron

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

ChEMBL

CHEMBL2095212

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

SMS_ID

100000126336

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

NDF-RT

N0000185007

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

Adrenergic beta3-Agonists [MoA]

MERCK INDEX

m11690

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

FDA UNII

MVR3JL3B2V

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

JAPANESE REVIEW

BETANIS

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

APPROVED JUNE 2011

CAS

223673-61-8

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

USAN

WW-31

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

DAILYMED

MVR3JL3B2V

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

IUPHAR

7445

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

NDF-RT

N0000182137

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

Cytochrome P450 2D6 Inhibitors [MoA]

EVMPD

SUB32690

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

CHEBI

65349

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

NCI_THESAURUS

C90633

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

RXCUI

1300786

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

RxNorm

DRUG CENTRAL

4382

Created by admin on Fri Dec 15 16:12:55 UTC 2023 , Edited by admin on Fri Dec 15 16:12:55 UTC 2023

PRIMARY

Related Record Type Details


					PG244BS39U

BETA-3 ADRENERGIC RECEPTOR

TARGET -> AGONIST

Interaction Type:

SHORT-ACTING

Amount:

Related Record Type Details


					RJ1WP0LG74

METABOLITE -> PARENT

Comments:

CYP 3A4 is the primary responsible isoenzyme for in vitro hepatic oxidative metabolism of mirabegron, with a minor role of CYP2D6


					RJ1WP0LG74

METABOLITE -> PARENT

Qualification:

PLASMA; URINE


					8Y8XEI3LHC

MIRABEGRON N-GLUCURONIDE

METABOLITE -> PARENT

Qualification:

PLASMA; URINE


					HW5B6351RZ

ACTARIT

METABOLITE -> PARENT

Qualification:

URINE


					8OBH7Z0622

YM-538853

METABOLITE -> PARENT

Comments:

In vitro studies suggest a role for CYP2D6 and CYP3A4 in the oxidative metabolism of mirabegron


					Q9302UF4GX

MIRABEGRON N-CARBAMOYLGLUCURONIDE

METABOLITE -> PARENT

Qualification:

PLASMA; URINE


					GR82L4OOM4

MIRABEGRON O-GLUCURONIDE

METABOLITE INACTIVE -> PARENT


					8OBH7Z0622

YM-538853

METABOLITE -> PARENT

Qualification:

PLASMA; URINE


					9B7762GTP4

YM-538858

METABOLITE INACTIVE -> PARENT

Comments:

In vitro and ex vivo studies have shown the involvement of uridine diphospho-glucuronosyltransferases (UGT)


					16J30IOW0V

2-((4-AMINOPHENETHYL)AMINO)-1-PHENYLETHANOL, (R)-

METABOLITE -> PARENT

Qualification:

PLASMA


					COV0W5ZLZF

3-HYDROXY YM-208876 GLUCURONIDE

METABOLITE -> PARENT

Qualification:

URINE


					9B7762GTP4

YM-538858

METABOLITE INACTIVE -> PARENT

Interaction Type:

MAJOR

Qualification:

PLASMA; URINE


					GR82L4OOM4

MIRABEGRON O-GLUCURONIDE

METABOLITE INACTIVE -> PARENT

Interaction Type:

MAJOR

Qualification:

PLASMA; URINE


					MI8N2779MA

YM-538852

METABOLITE -> PARENT

Qualification:

PLASMA; URINE

Related Record Type Details


					S5WN6RQZ9B

2-[[2-(4-Nitrophenyl)-ethyl]amino]-1-phenylethanol, (R)-

PARENT -> IMPURITY

Amount:

Related Record Type Details


					MVR3JL3B2V

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC		`MVR3JL3B2V` MIRABEGRON		Elimination PHARMACOKINETIC