Betinukibart

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 05:44:44 GMT 2025` Edited by `admin` on `Wed Apr 02 05:44:44 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	OIQ1SI09EU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

H-gamma1 heavy chain (1-447) [VH (Homo sapiens IGHV7-4-1*02 (90.7%) -(IGHD) -IGHJ4*01 (93.3%) L123>T (112), CDR-IMGT [8.8.10] (26-33.51-58.97-106)) (1-117) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v14 CH2 A1.3, A1.2 (CH1 R120 (214) (

Preferred Name

English

Betinukibart

Official Name

English

Immunoglobulin G1-kappa, anti-[Homo sapiens IL17A (interleukin 17A, IL-17A)]

Common Name

English

betinukibart [INN]

Common Name

English

Code System Code Type Description

CAS

2744274-11-9

Created by admin on Wed Apr 02 05:44:44 GMT 2025 , Edited by admin on Wed Apr 02 05:44:44 GMT 2025

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INN

13289

Created by admin on Wed Apr 02 05:44:44 GMT 2025 , Edited by admin on Wed Apr 02 05:44:44 GMT 2025

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FDA UNII

OIQ1SI09EU

Created by admin on Wed Apr 02 05:44:44 GMT 2025 , Edited by admin on Wed Apr 02 05:44:44 GMT 2025

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SMS_ID

300000056804

Created by admin on Wed Apr 02 05:44:44 GMT 2025 , Edited by admin on Wed Apr 02 05:44:44 GMT 2025

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NCI_THESAURUS

C211792

Created by admin on Wed Apr 02 05:44:44 GMT 2025 , Edited by admin on Wed Apr 02 05:44:44 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_144	2_200
2_220	4_219
2_261	2_321
1_144	1_200
2_367	2_425
3_23	3_93
3_139	3_199
4_23	4_93
4_139	4_199
1_220	3_219
1_226	2_226
1_229	2_229
1_261	1_321
1_367	1_425

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_297
N	2_297

Related Record Type Details


					R44E6C7B6J

INTERLEUKIN-17A

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					OIQ1SI09EU

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_34] [1_252] [2_34] [2_252] [3_4] [4_4]	SITE_SPECIFIC		Amount:	METHIONINE SULFOXIDE	XN1XVI4B2C
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q	Amount:	PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_447] [2_447]	C-TERMINUS		Amount:	LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL