GEMIFLOXACIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H20FN5O4
Molecular Weight	389.3809
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of GEMIFLOXACIN

Structure Search

SMILES

CO\N=C1/CN(CC1CN)C2=C(F)C=C3C(=O)C(=CN(C4CC4)C3=N2)C(O)=O

InChI

InChIKey=ZRCVYEYHRGVLOC-HYARGMPZSA-N

InChI=1S/C18H20FN5O4/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27)/b22-14+

HIDE SMILES / InChI

Molecular Formula	C18H20FN5O4
Molecular Weight	389.3809
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	1
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:50:50 UTC 2023` Edited by `admin` on `Sat Dec 16 16:50:50 UTC 2023`
Record UNII	OKR68Y0E4T
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

GEMIFLOXACIN

Official Name

English

1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, 7-(3-(AMINOMETHYL)-4-(METHOXYIMINO)-1-PYRROLIDINYL)-1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4- OXO-

Common Name

English

gemifloxacin [INN]

Common Name

English

7-(3-AMINOMETHYL-4-METHOXYIMINO-PYRROLIDINE-1-YL)-1-CYCLOPROPYL-6-FLUORO-4-OXO-1,4-DIHYDRO-(1,8)-NAPHTHYRIDINE-3-CARBOXYLIC ACID

Systematic Name

English

GEMIFLOXACIN [VANDF]

Common Name

English

(±)-7-(3-(AMINOMETHYL)-4-OXO-1-PYRROLIDINYL)-1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, 7(SUP 4)-(Z)-(O)-METHYLOXIME)

Common Name

English

GEMIFLOXACIN [MI]

Common Name

English

FACTIV

Brand Name

English

Gemifloxacin [WHO-DD]

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000007606

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

LIVERTOX

NBK548790

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

WHO-VATC

QJ01MA15

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

NDF-RT

N0000175937

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

NCI_THESAURUS

C795

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

WHO-ATC

J01MA15

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

Code System Code Type Description

MESH

C103274

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

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MERCK INDEX

m5693

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

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Merck Index

RXCUI

138099

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

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RxNorm

ChEMBL

CHEMBL430

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

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LACTMED

Gemifloxacin

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

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DRUG BANK

DB01155

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

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FDA UNII

OKR68Y0E4T

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

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CAS

175463-14-6

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

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EVMPD

SUB27752

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

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PUBCHEM

9571107

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

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CHEBI

101853

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

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NCI_THESAURUS

C61775

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

PRIMARY

DAILYMED

OKR68Y0E4T

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

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HSDB

8027

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

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INN

7877

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

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EPA CompTox

DTXSID3048495

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

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SMS_ID

100000091862

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

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DRUG CENTRAL

1286

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

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WIKIPEDIA

GEMIFLOXACIN

Created by admin on Sat Dec 16 16:50:51 UTC 2023 , Edited by admin on Sat Dec 16 16:50:51 UTC 2023

PRIMARY

Related Record Type Details


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Comments:

In vitro binding of gemifloxacin to plasma proteins in healthy subjects is approximately 60 to 70% and is concentration independent.

Interaction Type:

BINDING

Amount:


					3U6TN9Y2LD

MYCOPLASMA FERMENTANS

TARGET ORGANISM->INHIBITOR

Comments:

18 STRAINS LESS THE 8 ng/mL for many strains

Qualification:

MIC90

Amount:


					4AF605U6JN

MRP-2

TRANSPORTER -> INHIBITOR


					VJ8JLV45C6

GEMIFLOXACIN, (R)-

ENANTIOMER -> RACEMATE


					X4S9F8RL01

GEMIFLOXACIN MESYLATE

SALT/SOLVATE -> PARENT


					W0R460EMMJ

GEMIFLOXACIN, (S)-

ENANTIOMER -> RACEMATE

Related Record Type Details


					OKR68Y0E4T

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Tmax	PHARMACOKINETIC				ORAL ADMINISTRATION

Biological Half-life	PHARMACOKINETIC				AT STEADY-STATE