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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Mon Mar 31 22:54:47 GMT 2025
Edited
by admin
on Mon Mar 31 22:54:47 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
4AF605U6JN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ABC30
Preferred Name English
MRP-2
Common Name English
DJS
Common Name English
KIAA1010
Common Name English
MRP2
Common Name English
CMOAT1
Common Name English
CANALICULAR MULTIDRUG RESISTANCE PROTEIN
Common Name English
CMOAT
Common Name English
CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER 1
Common Name English
MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2
Common Name English
CMRP
Common Name English
ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 2
Common Name English
ABCC2
Common Name English
Classification Tree Code System Code
UCSF-FDA TRANSPORTAL ABCC2
Created by admin on Mon Mar 31 22:54:47 GMT 2025 , Edited by admin on Mon Mar 31 22:54:47 GMT 2025
Code System Code Type Description
FDA UNII
4AF605U6JN
Created by admin on Mon Mar 31 22:54:47 GMT 2025 , Edited by admin on Mon Mar 31 22:54:47 GMT 2025
PRIMARY
UNIPROT
Q92887
Created by admin on Mon Mar 31 22:54:47 GMT 2025 , Edited by admin on Mon Mar 31 22:54:47 GMT 2025
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_7
N 1_12
N 1_1011
Related Record Type Details
HUMAN PLACENTAL TISSUE
TISSUE EXPRESSION->TRANSPORTER
Structure of SULFINPYRAZONE
INHIBITOR -> TARGET
Structure of OPICAPONE
SUBSTRATE -> TRANSPORTER
Structure of RESVERATROL
INHIBITOR -> TRANSPORTER
inhibited MTX efflux transport in MDR1-MDCK and MRP2-MDCK cellmonolayers, suggesting that the target of drug interaction wasMDR1 andMRP2 in the intestine duringthe absorption process.
Structure of SCUTELLARIN
INHIBITOR -> TRANSPORTER
IC50
Structure of IPTACOPAN
SUBSTRATE -> TRANSPORTER
Structure of EFAVIRENZ
INHIBITOR -> TRANSPORTER
Structure of Cabozantinib
SUBSTRATE -> TRANSPORTER
Structure of ENCEQUIDAR
NON-INHIBITOR -> TRANSPORTER
Structure of RIFAMPIN
INHIBITOR -> TRANSPORTER
Structure of BILIRUBIN
SUBSTRATE -> TRANSPORTER
MAJOR
Structure of CISPLATIN
SUBSTRATE -> TRANSPORTER
Structure of LETERMOVIR
INHIBITOR -> TRANSPORTER
Structure of TECHNETIUM TC-99M MEBROFENIN
SUBSTRATE -> TRANSPORTER
MEB (0.4 nM) transport by MRP2 was inhibited to 12% of control by MK571 (50 ?M).
Structure of INDOMETHACIN
INHIBITOR -> TRANSPORTER
Structure of 25OHD3-3-O-GLUCURONIDE
SUBSTRATE -> TRANSPORTER
Structure of LY-3509754
INHIBITOR -> TRANSPORTER
Structure of GRAZOPREVIR ANHYDROUS
INHIBITOR -> TRANSPORTER
IC50
Structure of (2S,3S,4S,5R,6S)-6-((E)-((3-BROMO-4-FLUORO-ANILINO)-(4-(2-(SULFAMOYLAMINO)ETHYLAMINO)-1,2,5-OXADIAZOL-3-YL)METHYLENE)AMINO)OXY-3,4,5-TRIHYDROXY-TETRAHYDROPYRAN-2-CARBOXYLIC ACID
SUBSTRATE -> TRANSPORTER
Structure of OMEPRAZOLE
INHIBITOR -> METABOLIC ENZYME
Structure of MK-571
INHIBITOR -> TRANSPORTER
Structure of 1-(((4-((7-METHOXY-6-(SULFOOXY)-4-QUINOLINYL)OXY)PHENYL)AMINO)CARBONYL)CYCLOPROPANECARBOXYLIC ACID
SUBSTRATE -> TRANSPORTER
Structure of NINGETINIB
NON-SUBSTRATE -> TRANSPORTER
Structure of 1-(((4-((7-METHOXY-6-(SULFOOXY)-4-QUINOLINYL)OXY)PHENYL)AMINO)CARBONYL)CYCLOPROPANECARBOXYLIC ACID
INHIBITOR -> TRANSPORTER
IC50
Structure of RIFABUTIN
SUBSTRATE -> METABOLIC ENZYME
Structure of EMTRICITABINE
INHIBITOR -> TRANSPORTER
Structure of ETOPOSIDE
SUBSTRATE -> TRANSPORTER
Structure of GEMIFLOXACIN
INHIBITOR -> TRANSPORTER
Structure of Cyclosporine
INHIBITOR -> TRANSPORTER
Structure of DELAVIRDINE
INHIBITOR -> TRANSPORTER
Structure of CANAGLIFLOZIN ANHYDROUS
SUBSTRATE -> TRANSPORTER
Structure of ELUXADOLINE
SUBSTRATE -> TRANSPORTER
Based on in-vitro studies, eluxadoline appears to be a substrate for OAT3, OATP1B1, BSEP, and MRP2
Structure of SCUTELLARIN
SUBSTRATE -> TRANSPORTER
Structure of DAUNORUBICIN
INHIBITOR -> TRANSPORTER
Structure of VINCRISTINE
INHIBITOR -> TRANSPORTER
Structure of ZIDOVUDINE
NON-SUBSTRATE -> TRANSPORTER
Structure of OMEPRAZOLE
INHIBITOR -> TRANSPORTER
Structure of BRANEBRUTINIB
NON-INHIBITOR -> TRANSPORTER
Structure of CURCUMIN
INHIBITOR -> TRANSPORTER
Structure of METHOTREXATE
SUBSTRATE -> TRANSPORTER
Structure of VALSPODAR
INHIBITOR -> TRANSPORTER
Structure of Folic acid
SUBSTRATE -> TRANSPORTER
Structure of BMS-962212
SUBSTRATE -> TRANSPORTER
Structure of INDINAVIR
SUBSTRATE -> TRANSPORTER
Structure of VINCRISTINE
SUBSTRATE -> TRANSPORTER
Structure of BT-070
INHIBITOR -> TRANSPORTER
Structure of Cyclosporine
INHIBITOR -> METABOLIC ENZYME
Structure of Glutathione
SUBSTRATE -> TRANSPORTER
Structure of ETOPOSIDE
INHIBITOR -> TRANSPORTER
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL
NIH
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