Ibramvibart

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 20:33:41 GMT 2025` Edited by `admin` on `Wed Apr 02 20:33:41 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|LAMDA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	PRC4J48944
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Ibramvibart

Official Name

English

VYD-2311

Preferred Name

English

VYD2311

Code

English

ibramvibart [INN]

Common Name

English

immunoglobulin G1-kappa, anti-[severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein, receptor binding domain (RBD)], Homo sapiens monoclonal antibody (Ibramvibart)

Common Name

English

Immunoglobulin G1 [435-leucine,441-alanine], anti-(severe acute respiratory syndrome coronavirus 2 spike glycoprotein receptor-binding domain) (human monoclonal VYD2311 ?1-chain), disulfide with human monoclonal VYD2311 ?-chain, dimer

Common Name

English

H-gamma1 heavy chain Homo sapiens (1-454) [VH (Homo sapiens IGHV3-21*07 (88.8%) -(IGHD) -IGHJ4*01 (92.9%), CDRIMGT [8.8.17] (26-33.51-58.97-113)) (1-124) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, 9-G1v78 CH3 L107 A114 (CH1 R120 (221) (1

Common Name

English

Code System Code Type Description

FDA UNII

PRC4J48944

Created by admin on Wed Apr 02 20:33:41 GMT 2025 , Edited by admin on Wed Apr 02 20:33:41 GMT 2025

PRIMARY

CAS

3031270-42-2

Created by admin on Wed Apr 02 20:33:41 GMT 2025 , Edited by admin on Wed Apr 02 20:33:41 GMT 2025

PRIMARY

INN

13806

Created by admin on Wed Apr 02 20:33:41 GMT 2025 , Edited by admin on Wed Apr 02 20:33:41 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_151	2_207
2_227	4_217
2_268	2_328
1_151	1_207
2_374	2_432
3_22	3_90
3_140	3_199
4_22	4_90
4_140	4_199
1_227	3_217
1_233	2_233
1_236	2_236
1_268	1_328
1_374	1_432

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_304
N	2_304

Related Record Type Details


					B6L4N5Z4GH

SARS-COV2

TARGET ORGANISM->INHIBITOR

Amount:

Related Record Type Details


					PRC4J48944

Ibramvibart

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[3_1] [4_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_454] [2_454]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL