ALPHA-1B ADRENERGIC RECEPTOR

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 18:35:05 GMT 2025` Edited by `admin` on `Tue Apr 01 18:35:05 GMT 2025`
Protein Type	RECEPTOR
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	Q7A4S7HOP4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ADRA1B

Preferred Name

English

ALPHA-1B ADRENERGIC RECEPTOR

Common Name

English

ALPHA-1B ADRENORECEPTOR

Common Name

English

Code System Code Type Description

UNIPROT

P35368

Created by admin on Tue Apr 01 18:35:05 GMT 2025 , Edited by admin on Tue Apr 01 18:35:05 GMT 2025

PRIMARY

FDA UNII

Q7A4S7HOP4

Created by admin on Tue Apr 01 18:35:05 GMT 2025 , Edited by admin on Tue Apr 01 18:35:05 GMT 2025

PRIMARY

From	To
1_118	1_195

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_10
N	1_24
N	1_29
N	1_34

Related Record Type Details


					1WS297W6MV

AGONIST -> TARGET

Comments:

Binding Assay

Qualification:

IC50

Amount:


					J7A92W69L7

DROXIDOPA

AGONIST -> TARGET

Amount:


					NW1291F1W8

DOXAZOSIN

INHIBITOR -> TARGET

Amount:


					8VLN5B44ZY

AGONIST -> TARGET

Qualification:

IC50

Amount:


					V3H1ZVV9S6

INHIBITOR -> TARGET

Qualification:

Ki

Amount:


					U42B7VYA4P

INHIBITOR -> TARGET


					NW1291F1W8

DOXAZOSIN

AGONIST -> TARGET

Amount:


					2J3YBM1K8C

INHIBITOR -> TARGET


					YKH834O4BH

AGONIST -> TARGET

Amount:


					G3P28OML5I

INHIBITOR -> TARGET

Qualification:

Ki

Amount:


					E9H51OIT2B

WB-4101

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					8L5014XET7

TERAZOSIN

INHIBITOR -> TARGET


					6YE7PBM15H

MIDODRINE

AGONIST -> TARGET

Amount:


					5RNZ8GJO7K

INHIBITOR -> TARGET


					6QZ7XLY9SJ

LIGAND->TARGET

Comments:

Binding assay

Qualification:

Kd

Amount:


					CR7JLF2GBM

L-765314

INHIBITOR -> TARGET

Interaction Type:

ANTAGONIST

Amount:


					XM03YJ541D

PRAZOSIN

INHIBITOR -> TARGET

Amount:


					BGL0JSY5SI

INHIBITOR -> TARGET

Qualification:

Ki

Amount:


					90347YTW5F

ALFUZOSIN

AGONIST -> TARGET


					X4W3ENH1CV

AGONIST -> TARGET

Amount:


					90347YTW5F

ALFUZOSIN

INHIBITOR -> TARGET


					CUZ39LUY82

SILODOSIN

INHIBITOR->OFF-TARGET

Comments:

Selectivity of silodosin determined in cloned human ?1-adrenergic receptor (?1-AR) subtypes in cultured Chinese hamster ovary cells.

Qualification:

Ki

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_264]				THREONINE PHOSPHATE	3L4WX7B1EI

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT	CHEMICAL