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Details

Stereochemistry ACHIRAL
Molecular Formula C15H22O3
Molecular Weight 250.3334
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GEMFIBROZIL

SMILES

CC1=CC(OCCCC(C)(C)C(O)=O)=C(C)C=C1

InChI

InChIKey=HEMJJKBWTPKOJG-UHFFFAOYSA-N
InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)

HIDE SMILES / InChI
Molecular Formula C15H22O3
Molecular Weight 250.3334
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
123738
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:19:58 UTC 2023
Edited
by admin
on Fri Dec 15 15:19:58 UTC 2023
Record UNII
Q8X02027X3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GEMFIBROZIL
EP   HSDB   INN   JAN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
INCI   USAN   INN  
Official Name English
GEMFIBROZIL [IARC]
Common Name English
Gemfibrozil [WHO-DD]
Common Name English
GEMFIBROZIL [HSDB]
Common Name English
2,2-DIMETHYL-5-(2,5-XYLYLOXY) VALERIC ACID
Systematic Name English
gemfibrozil [INN]
Common Name English
GEMFIBROZIL [EP MONOGRAPH]
Common Name English
GEMFIBROZIL [MART.]
Common Name English
GEMFIBROZIL [USAN]
Common Name English
GEMFIBROZIL [USP-RS]
Common Name English
GEMFIBROZIL [JAN]
Common Name English
NSC-757024
Code English
GEMFIBROZIL [ORANGE BOOK]
Common Name English
GEMFIBROZIL [MI]
Common Name English
GEMFIBROZIL [INCI]
Common Name English
CI-719
Code English
GEMFIBROZIL [USP MONOGRAPH]
Common Name English
PENTANOIC ACID, 5-(2,5-DIMETHYLPHENOXY)-2,2-DIMETHYL-
Common Name English
LOPID
Brand Name English
GEMFIBROZIL [VANDF]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 834821
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
FDA ORPHAN DRUG 591917
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
EU-Orphan Drug EU/3/18/1993
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
NCI_THESAURUS C98150
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
WHO-VATC QC10AB04
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
FDA ORPHAN DRUG 591917
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
FDA ORPHAN DRUG 546216
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
NDF-RT N0000170118
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
NDF-RT N0000175375
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
NDF-RT N0000175596
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
WHO-ATC C10AB04
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
NDF-RT N0000170118
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
LIVERTOX NBK547926
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
FDA ORPHAN DRUG 834921
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
Code System Code Type Description
CAS
25812-30-0
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
HSDB
7735
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
DRUG BANK
DB01241
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
DAILYMED
Q8X02027X3
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
ECHA (EC/EINECS)
247-280-2
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
INN
3899
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
SMS_ID
100000092643
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
EPA CompTox
DTXSID0020652
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
EVMPD
SUB07894MIG
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
FDA UNII
Q8X02027X3
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
DRUG CENTRAL
1285
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
NSC
757024
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
IUPHAR
3439
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
RXCUI
4719
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY RxNorm
MESH
D015248
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
RS_ITEM_NUM
1288500
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
LACTMED
Gemfibrozil
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
NCI_THESAURUS
C29071
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
MERCK INDEX
m5692
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY Merck Index
ChEMBL
CHEMBL457
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
WIKIPEDIA
GEMFIBROZIL
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
CHEBI
5296
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
PUBCHEM
3463
Created by admin on Fri Dec 15 15:19:58 UTC 2023 , Edited by admin on Fri Dec 15 15:19:58 UTC 2023
PRIMARY
Related Record Type Details
CYTOCHROME P450 2C8
METABOLIC ENZYME -> INHIBITOR
MAJOR
IC50
Structure of GEMFIBROZIL
EXCRETED UNCHANGED
URINE
PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA
TARGET -> ACTIVATOR
with 100% efficacy
EC50
OATP-B
TRANSPORTER -> INHIBITOR
SUBSTRATE USED: ESTRONE-3-SULFATE
SODIUM/BILE ACID COTRANSPORTER
TRANSPORTER -> INHIBITOR
OAT-3
TRANSPORTER -> INHIBITOR
CYTOCHROME P450 3A4
METABOLIC ENZYME -> NON-INHIBITOR
OATP1B1
TRANSPORTER -> INHIBITOR
PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
TARGET -> ACTIVATOR
with 79% efficacy
EC50
Related Record Type Details
Structure of BENZOIC ACID, 3-((4-CARBOXY-4-METHYLPENTYL)OXY)-4-METHYL-
METABOLITE -> PARENT
IN VITRO
Structure of GEMFIBROZIL 1-O-.BETA.-GLUCURONIDE
METABOLITE -> PARENT
Structure of 5-(4-HYDROXY-2,5-DIMETHYLPHENOXY)-2,2-DIMETHYLPENTANOIC ACID
METABOLITE -> PARENT
IN VITRO
Structure of 5-(5-(HYDROXYMETHYL)-2-METHYLPHENOXY)-2,2-DIMETHYLPENTANOIC ACID
METABOLITE -> PARENT
IN VITRO
Related Record Type Details
6'-PROPENE-1-YL GEMFIBROZIL
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 2,2-DIMETHYL-5-(2,5-XYLYLOXY)VALERAMIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 2,5-XYLENOL
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 1,1'-(PROPANE-1,3-DIYLBIS(OXY))BIS(2,5-DIMETHYLBENZENE)
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of GEMFIBROZIL METHYL ESTER
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 1,4-DIMETHYL-2-(4-PHENYLBUTOXY)BENZENE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
5-(2,5-DIMETHYL-4-(PROP-1-EN-1-YL)PHENOXY)-2,2-DIMETHYLPENTANOIC ACID
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 5-(2,5-DIMETHYL-4-((1Z)-PROP-1-EN-1-YL)PHENOXY)-2,2-DIMETHYLPENTANOIC ACID
IMPURITY -> PARENT
Structure of 5-(2,5-DIMETHYL-4-((1E)-PROP-1-EN-1-YL)PHENOXY)-2,2-DIMETHYLPENTANOIC ACID
IMPURITY -> PARENT
Structure of 2-(3-(2-ETHOXYETHOXY)PROPOXY)-1,4-DIMETHYLBENZENE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 1,4-DIMETHYL-2-(2-PROPEN-1-YLOXY)BENZENE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of GEMFIBROZIL
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Tmax PHARMACOKINETIC ORAL ADMINISTRATION

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