U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 18:37:10 GMT 2025
Edited
by admin
on Tue Apr 01 18:37:10 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
AL17N8ZSWL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
Common Name English
NUCLEAR RECEPTOR SUBFAMILY 1 GROUP C MEMBER 3
Preferred Name English
PPAR-GAMMA
Common Name English
PPARG
Common Name English
Code System Code Type Description
FDA UNII
AL17N8ZSWL
Created by admin on Tue Apr 01 18:37:10 GMT 2025 , Edited by admin on Tue Apr 01 18:37:10 GMT 2025
PRIMARY
UNIPROT
P37231
Created by admin on Tue Apr 01 18:37:10 GMT 2025 , Edited by admin on Tue Apr 01 18:37:10 GMT 2025
PRIMARY
WIKIPEDIA
PEROXISOME_PROLIFERATOR-ACTIVATED_RECEPTOR_GAMMA
Created by admin on Tue Apr 01 18:37:10 GMT 2025 , Edited by admin on Tue Apr 01 18:37:10 GMT 2025
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
O 1_84
Related Record Type Details
Structure of MK-0767
AGONIST -> TARGET
Structure of REGLITAZAR
AGONIST -> TARGET
Structure of SODELGLITAZAR
AGONIST -> TARGET
Structure of 15-DEOXY-.DELTA.12,14-PROSTAGLANDIN J2
AGONIST -> TARGET
Binding Assay
IC50
Structure of Sulfasalazine
AGONIST -> TARGET
Structure of LY-510929
AGONIST -> TARGET
Structure of Saroglitazar
AGONIST -> TARGET
sarogli tazar has a predominant affinity for the PPAR-α isoform, and an intermediate affinity for PPAR-γ
Structure of AZD-6610
AGONIST -> TARGET
Structure of DEUTEROPIOGLITAZONE, (R)-
AGONIST -> TARGET
Structure of PIOGLITAZONE
AGONIST -> TARGET
Structure of EDAGLITAZONE
AGONIST -> TARGET
Structure of CARFLOGLITAZAR
AGONIST -> TARGET
Structure of PELIGLITAZAR
AGONIST -> TARGET
Structure of IMIGLITAZAR
AGONIST -> TARGET
Structure of PEMAGLITAZAR
AGONIST -> TARGET
Structure of PF-05089771
INHIBITOR->OFF-TARGET
Ki
Structure of ROSIGLITAZONE
INHIBITOR -> TARGET
Binding Assay
IC50
Structure of CHIGLITAZAR
INHIBITOR -> TARGET
Structure of IBRIGAMPAR
PARTIAL AGONIST->TARGET
In a cell-based reporter assay designed to detect full agonist activity, INT131 activates PPAR? with an efficacy of only about 10% of that of rosiglitazone.
BINDING
Ki
Structure of GEMFIBROZIL
ACTIVATOR -> TARGET
Structure of LANIFIBRANOR
AGONIST -> TARGET
Structure of FARGLITAZAR
AGONIST -> TARGET
Structure of DARGLITAZONE
AGONIST -> TARGET
Structure of ALEGLITAZAR
AGONIST -> TARGET
Structure of Ibrilatazar
AGONIST -> TARGET
Structure of RAGAGLITAZAR
AGONIST -> TARGET
Structure of ERTIPROTAFIB
AGONIST -> TARGET
Structure of CEVOGLITAZAR
AGONIST -> TARGET
Structure of AVE-0897
AGONIST -> TARGET
Structure of KDT-500, (+)-
WEAK AGONIST->TARGET
Structure of CARFLOGLITAZAR, (R)-
WEAK AGONIST->TARGET
Structure of BALAGLITAZONE
PARTIAL AGONIST->TARGET
Structure of ETALOCIB
AGONIST -> TARGET
Structure of FX-909
INVERSE AGONIST->TARGET
In cells covalently binds. FX-909 potently suppressed PPARG target gene mRNA at half maximal inhibitory concentration (IC50) values of 1-2 nM in cell lines that demonstrated activation of PPARG pathway signaling through RXRA mutation or PPARG amplification
IRREVERSIBLE INHIBITOR
IC50
Structure of GW-590735
ACTIVATOR -> TARGET
Structure of [3H] Rosiglitazone
LIGAND->TARGET
Binding Assay
Kd
Structure of TESAGLITAZAR
AGONIST -> TARGET
Tesaglitazar is a novel dual-acting peroxisome proliferator-activated receptor alpha and gamma agonist.
Structure of LOBEGLITAZONE
AGONIST -> TARGET
Structure of ACETAMIDOPHENYL METHOXYPROPIONIC ACID, (S)-
INHIBITOR -> TARGET
Structure of EFATUTAZONE
AGONIST -> TARGET
Structure of LERIGLITAZONE
AGONIST -> TARGET
Structure of GSK-183390
INHIBITOR -> TARGET
Structure of Etrinabdione
AGONIST -> TARGET
Structure of T0070907
INHIBITOR -> TARGET
IC50
Structure of BALSALAZIDE
AGONIST -> TARGET
Structure of INDEGLITAZAR
PARTIAL AGONIST->TARGET
Structure of 5-[(2,4-Dioxo-5-thiazolidinyl)methyl]-2-methoxy-N-[[4-(trifluoromethyl)phenyl]methyl]benzamide
AGONIST -> TARGET
TROGLITAZONE
AGONIST -> TARGET
Structure of NETOGLITAZONE
AGONIST -> TARGET
Structure of CIGLITAZONE
AGONIST -> TARGET
Binding Assay
IC50
Structure of OXEGLITAZAR
AGONIST -> TARGET
Structure of MURAGLITAZAR
AGONIST -> TARGET
Structure of NAVEGLITAZAR
AGONIST -> TARGET
Structure of SIPOGLITAZAR
AGONIST -> TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_176] [1_180] [1_190] [1_193] SITE_SPECIFIC C4-TYPE ZINC FINGER C56TF4V7OP
AMINO_ACID_SUBSTITUTION [1_139] [1_142] [1_156] [1_159] SITE_SPECIFIC C4-TYPE ZINC FINGER C56TF4V7OP
AMINO ACID SUBSTITUTION [1_112] DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
NIH
NCATS
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