Calotatug Ginistinag

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 15:57:54 GMT 2025` Edited by `admin` on `Wed Apr 02 15:57:54 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	RA7UQ7N2QE
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Calotatug Ginistinag

Official Name

English

H-gamma1 heavy chain Homo sapiens (1-446) [VH (Homo sapiens IGHV3-48*01 (100%) -(IGHD) -IGHJ2*01 (100%), CDR-IMGT [8.8.10] (26-33.51-58.97-106)) (1-117) -Homo sapiens IGHG1*01 (100%), G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (214) (118-215), hinge 1-15 (

Preferred Name

English

calotatug ginistinag [INN]

Common Name

English

Immunoglobulin G1 [de-447-lysine], anti-(human tyrosine kinase receptor HER2) (human monoclonal XMT-1519 ?1-chain), disulfide with human monoclonal XMT-1519 ?-chain, dimer, reduced, thioether with 1,1?-[[N5-[(11S)-16-[[5-(aminocarbonyl)-1-[(2E)-4-[6-(ami

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (receptor tyrosine-protein kinase erbB-2, epidermal growth factor receptor 2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], Homo sapiens monoclonal antibody, conjugated on 8 cysteinyl residues to a STING

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

877522

Created by admin on Wed Apr 02 15:57:54 GMT 2025 , Edited by admin on Wed Apr 02 15:57:54 GMT 2025

Code System Code Type Description

SMS_ID

300000054786

Created by admin on Wed Apr 02 15:57:54 GMT 2025 , Edited by admin on Wed Apr 02 15:57:54 GMT 2025

PRIMARY

INN

12945

Created by admin on Wed Apr 02 15:57:54 GMT 2025 , Edited by admin on Wed Apr 02 15:57:54 GMT 2025

PRIMARY

NCI_THESAURUS

C190297

Created by admin on Wed Apr 02 15:57:54 GMT 2025 , Edited by admin on Wed Apr 02 15:57:54 GMT 2025

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CAS

2847102-44-5

Created by admin on Wed Apr 02 15:57:54 GMT 2025 , Edited by admin on Wed Apr 02 15:57:54 GMT 2025

PRIMARY

FDA UNII

RA7UQ7N2QE

Created by admin on Wed Apr 02 15:57:54 GMT 2025 , Edited by admin on Wed Apr 02 15:57:54 GMT 2025

PRIMARY

From	To
1_23	1_89
1_135	1_195
1_215	3_220
2_23	2_89
2_135	2_195
2_215	4_220
3_22	3_96
3_144	3_200
3_261	3_321
3_367	3_425
4_22	4_96
4_144	4_200
4_261	4_321
4_367	4_425
3_226	4_226
3_229	4_229

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	3_297
N	4_297

Related Record Type Details


					7J9Y28299R

RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2

TARGET->LIGAND

Amount:


					92KA2XEZ4L

STIMULATOR OF INTERFERON GENES PROTEIN

TARGET -> AGONIST

Amount:

Related Record Type Details


					RA7UQ7N2QE

Calotatug Ginistinag

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC	C	Amount:	UNSPECIFIED SUBSTANCE	14d808ac (not in database)

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL