U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 18:39:44 GMT 2025
Edited
by admin
on Tue Apr 01 18:39:44 GMT 2025
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
SKEU5X23RI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CANNABINOID RECEPTOR TYPE 2
Preferred Name English
CANNABINOID RECEPTOR 2
Common Name English
CB2
Common Name English
Code System Code Type Description
UNIPROT
P34972
Created by admin on Tue Apr 01 18:39:45 GMT 2025 , Edited by admin on Tue Apr 01 18:39:45 GMT 2025
PRIMARY
FDA UNII
SKEU5X23RI
Created by admin on Tue Apr 01 18:39:45 GMT 2025 , Edited by admin on Tue Apr 01 18:39:45 GMT 2025
PRIMARY
PHAROS
P34972
Created by admin on Tue Apr 01 18:39:45 GMT 2025 , Edited by admin on Tue Apr 01 18:39:45 GMT 2025
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_11
Related Record Type Details
Structure of JWH-018
AGONIST -> TARGET
EC50
Structure of JWH-359
AGONIST -> TARGET
Selectivity of around 220 times for CB2 over CB1 receptors.
Ki
Structure of 5F-SDB-003
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of OLORINAB
AGONIST -> TARGET
Structure of ADB-FUBINACA
AGONIST -> TARGET
EC50
Structure of EG-2201
AGONIST -> TARGET
Ki
Structure of CUMYL-4CN-BINACA
AGONIST -> TARGET
A potent agonist
Structure of TAK-937
AGONIST -> TARGET
IC50
Structure of GSK-554418A
AGONIST -> TARGET
Structure of MDMB-FUBINACA
AGONIST -> TARGET
EC50
Structure of SER-601
AGONIST -> TARGET
Structure of DRONABINOL
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of AB-FUBINACA 2-FLUOROBENZYL ISOMER
AGONIST -> TARGET
Structure of 5-FLUORO-AB-PICA, (±)-
AGONIST -> TARGET
EC50
Structure of THJ-2201
AGONIST -> TARGET
Ki
Structure of ADBICA, (±)-
AGONIST -> TARGET
EC50
Structure of CANNABIDIOL
INVERSE AGONIST->TARGET
Structure of AM-679 (CANNABINOID)
AGONIST -> TARGET
Structure of CP-55940
AGONIST -> TARGET
Strong agonist
EC50
Structure of ADB-PINACA
AGONIST -> TARGET
EC50
Structure of AB-002
AGONIST -> TARGET
EC50
Structure of CL-2201
AGONIST -> TARGET
Ki
Structure of FUBIMINA
AGONIST -> TARGET
Ki
Structure of MN-18
AGONIST -> TARGET
Ki
Structure of JWH-387
AGONIST -> TARGET
Ki
Structure of XLR-11
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of MMB-FUBICA
AGONIST -> TARGET
Structure of ART-2713
AGONIST -> TARGET
Structure of SDB-005
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of MCHB-1
AGONIST -> TARGET
EC50
Structure of MN-25
AGONIST -> TARGET
MN-25 (UR-12) acts as a reasonably selective agonist of peripheral cannabinoid receptors. It has moderate affinity for CB2 receptors with a Ki of 11 nM.
Ki
Structure of TEDALINAB
AGONIST -> TARGET
Structure of LENABASUM
AGONIST -> TARGET
Structure of CMX-020
AGONIST -> TARGET
Structure of PF-03550096
AGONIST -> TARGET
Structure of ADB-FUBICA
AGONIST -> TARGET
EC50
Structure of NE-40
INVERSE AGONIST->TARGET
?69% of basal activity
EC50
Structure of CUMYL-PICA
AGONIST -> TARGET
Ki
Structure of ADB-PHETINACA
AGONIST -> TARGET
Structure of 5F-MDMB-PICA
AGONIST -> TARGET
Structure of JWH-080
AGONIST -> TARGET
Ki
Structure of 5-FLUORO PHENYL-PICA
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of AM-4030
AGONIST -> TARGET
Ki
Structure of PSB-SB-1202
AGONIST -> TARGET
Structure of AB-FUBINACA 3-FLUOROBENZYL ISOMER
AGONIST -> TARGET
Structure of AMB
AMB
AGONIST -> TARGET
Ki
Structure of ANANDAMIDE
AGONIST -> TARGET
IC50
Structure of 5F-BZO-POXIZID
AGONIST -> TARGET
Selectivity over the psychoactive CB1 receptor
Structure of ONTERNABEZ
AGONIST -> TARGET
Structure of RCS-3
AGONIST -> TARGET
EC50
Structure of STS-135
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
Structure of 5-FLUORO-CUMYL-PICA
AGONIST -> TARGET
Ki
Structure of F-2201
AGONIST -> TARGET
Ki
Structure of THJ-018
AGONIST -> TARGET
Structure of BIPICANA
AGONIST -> TARGET
Structure of WIN-55212-2
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of SDB-006
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of MDMB-CHMCZCA
INHIBITOR -> TARGET
Structure of 5-FLUORO-AB-PICA
AGONIST -> TARGET
Structure of BZO-CHMOXIZID
AGONIST -> TARGET
Emax 65% of CP55940
EC50
Structure of CID-16020046
LIGAND->TARGET
Structure of 5F-SDB-006
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of ADB-CHMINACA
AGONIST -> TARGET
Ki
Structure of 5-FLUORO-PB-22
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of BZO-4en-POXIZID
AGONIST -> TARGET
Emax=68.8
Structure of NABILONE
AGONIST -> TARGET
Structure of APP-CHMINACA
AGONIST -> TARGET
Ki
Structure of 5F-ADB
AGONIST -> TARGET
Ki
Structure of GW842166
AGONIST -> TARGET
Structure of WIN 54,461
INVERSE AGONIST->TARGET
Structure of AB-BICA
AGONIST -> TARGET
Structure of CBS-0550
AGONIST -> TARGET
High selectivity for CB2 (CB1 IC50/CB2 IC50 = 1400),
EC50
Structure of 5F-CUMYL-PINACA
AGONIST -> TARGET
Structure of AM-1241
AGONIST -> TARGET
Structure of 5-CHLORO-AB-PINACA
AGONIST -> TARGET
Ki
Structure of BIM-018
AGONIST -> TARGET
Structure of UR-144
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of NMP-7
AGONIST -> TARGET
Structure of PB-22
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of BZO-HEXOXIZID
AGONIST -> TARGET
Structure of MMB-018
AGONIST -> TARGET
Structure of 5F-CUMYL-P7AICA
AGONIST -> TARGET
EC50
Structure of 5F-ADB-PINACA
AGONIST -> TARGET
EC50
Structure of 5-FLUORO-AMB-PICA
AGONIST -> TARGET
Ki
Structure of 5-FLUORO-MN-18
AGONIST -> TARGET
Ki
Structure of LY-2828360
AGONIST -> TARGET
Structure of PX-1
AGONIST -> TARGET
Ki
Structure of APP-FUBINACA
AGONIST -> TARGET
Ki
Structure of MDMB-CHMINACA
AGONIST -> TARGET
Ki
Structure of ADBICA
AGONIST -> TARGET
Structure of SDB-004
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of NESS-040C5
AGONIST -> TARGET
Ki
Structure of SERINOLAMIDE A
AGONIST -> TARGET
Structure of JWH-307
AGONIST -> TARGET
Structure of AB-001 (cannabinoid)
AGONIST -> TARGET
Structure of BZO-POXIZID
AGONIST -> TARGET
Emax=68.8
EC50
Structure of NE-40 C-11
RADIOLIGAND->TARGET
Highly selective. Binding to the CB1 receptor KihCB1 >1000 nM
BINDING
Ki
Structure of AB-FUBICA
AGONIST -> TARGET
EC50
Structure of 5F-ADBICA
AGONIST -> TARGET
EC50
Structure of CUMYL-THPINACA
AGONIST -> TARGET
Ki
Structure of RoSMA-18-d6
AGONIST -> TARGET
Ki
Structure of AMG-1
AGONIST -> TARGET
Structure of WIN 55212-2 H-3
RADIOLIGAND->TARGET
Kd
Structure of RCS-2
AGONIST -> TARGET
Structure of MDMB-CHMICA
AGONIST -> TARGET
Ki
Structure of AMB-FUBINACA
AGONIST -> TARGET
Ki
Structure of JWH-018
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of MA-CHMINACA
AGONIST -> TARGET
Ki
Structure of AB-CHMINACA
AGONIST -> TARGET
Ki
Structure of 2-ARACHIDONOYLGLYCEROL
AGONIST -> TARGET
The primary endogenous ligand for the CB2
Structure of FUB-JWH-018
AGONIST -> TARGET
Ki
Structure of EG-018
AGONIST -> TARGET
Ki
Structure of 5-FLUORO-AMP
AGONIST -> TARGET
Ki
Structure of AB-PINACA
AGONIST -> TARGET
EC50
Structure of 5-FLUORO-AB-PINACA
AGONIST -> TARGET
EC50
Structure of APICA
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of EAM-2201
AGONIST -> TARGET
Ki
Structure of N-(2S,3S)-3-ETHYL-3-DIDEMETHYL 5-FLUORO ADB-PINACA
AGONIST -> TARGET
Ki
Structure of FDU-NNE1
AGONIST -> TARGET
Ki
Structure of MEPIRAPIM
WEAK AGONIST->TARGET
Ki
Structure of 5F-EMB-PINACA
AGONIST -> TARGET
Structure of RCS-4
AGONIST -> TARGET
EC50
Structure of AB-FUBINACA
AGONIST -> TARGET
EC50
Structure of UR-144 N-5-HYDROXYPENTYL
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of RCS-4 C4
AGONIST -> TARGET
EC50
Structure of MN-24
AGONIST -> TARGET
Ki
Structure of AM-2201
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of 5F-SDB-002
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of AB-PICA
AGONIST -> TARGET
EC50
Structure of [18F]RoSMA-18-d6
RADIOLIGAND->TARGET
Ki
Structure of 5-FLUORO-MN-24
AGONIST -> TARGET
Ki
Structure of CBL-018
AGONIST -> TARGET
Structure of 5F-SDB-004
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of SDB-003
AGONIST -> TARGET
Mouse AtT-20 neuroblastoma cells stably transfected with human CB2
EC50
Structure of MO-CHMINAKA
AGONIST -> TARGET
Ki

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_335] [1_336] [1_352] DEXFOSFOSERINE VI4F0K069V
AMINO ACID SUBSTITUTION [1_338] THREONINE PHOSPHATE 3L4WX7B1EI
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL
NIH
NCATS
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