VINCRISTINE SULFATE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C46H56N4O10.H2O4S
Molecular Weight	923.036
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of VINCRISTINE SULFATE

Structure Search

SMILES

OS(O)(=O)=O.[H][C@@]12N3CC[C@@]14C5=CC(=C(OC)C=C5N(C=O)[C@@]4([H])[C@](O)([C@H](OC(C)=O)[C@]2(CC)C=CC3)C(=O)OC)[C@]6(C[C@H]7CN(C[C@](O)(CC)C7)CCC8=C6NC9=CC=CC=C89)C(=O)OC

InChI

InChIKey=AQTQHPDCURKLKT-PNYVAJAMSA-N

InChI=1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	C46H56N4O10
Molecular Weight	824.9576
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	9 / 9
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	H2O4S
Molecular Weight	98.078
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:00:13 UTC 2023` Edited by `admin` on `Fri Dec 15 15:00:13 UTC 2023`
Record UNII	T5IRO3534A
Record Status	`Validated (UNII)`
Record Version

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Related Record	Type

Name

Type

Language

VINCRISTINE SULFATE

Official Name

English

VINCRISTINE SULFATE [IARC]

Common Name

English

VINCRISTINI SULFAS [WHO-IP LATIN]

Common Name

English

VINCRISUL

Common Name

English

22-OXOVINCALEUKOBLASTINE SULFATE (1:1) (SALT) [WHO-IP]

Common Name

English

VINCRISTINE SULFATE [MART.]

Common Name

English

37231

Code

English

Leurocristine sulfate (1:1) (salt)

Common Name

English

NSC-67574

Code

English

VINCRISTINE SULFATE [JAN]

Common Name

English

Vincristine sulfate [WHO-DD]

Common Name

English

VINCRISTINE SULFATE [USAN]

Common Name

English

VINCRISTINE SULFATE [EP MONOGRAPH]

Common Name

English

VINCRISTINE SULFATE [USP-RS]

Common Name

English

KYOCRISTINE

Common Name

English

VINCALEUKOBLASTINE, 22-OXO-, SULFATE (1:1) (SALT)

Common Name

English

VINCRISTINE SULFATE [VANDF]

Common Name

English

ONCOVIN

Brand Name

English

VINCRISTINE SULFATE [WHO-IP]

Common Name

English

VINCREX

Brand Name

English

VINCRISTINE SULFATE [MI]

Common Name

English

VINCRISTINE SULPHATE

Common Name

English

NOVOPHARM

Common Name

English

LILLY-37231

Code

English

VINCRISTINE SULFATE [USP MONOGRAPH]

Common Name

English

VINCRISTINE SULFATE [ORANGE BOOK]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

259108

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

EU-Orphan Drug

EU/3/08/555

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

NCI_THESAURUS

C932

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

NCI_THESAURUS

C67422

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

Code System Code Type Description

MERCK INDEX

m11453

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

Merck Index

EPA CompTox

DTXSID8044331

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

CHEBI

28445

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

PUBCHEM

5388992

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

WHO INTERNATIONAL PHARMACOPEIA

VINCRISTINE SULFATE

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

Description: A white to slightly yellow, amorphous or crystalline powder; odourless. Solubility: Freely soluble in water; slightly soluble in ethanol (~750 g/l) TS; practically insoluble in ether R. Category: Cytotoxic drug. Storage: Vincristine sulfate should be kept in a tightly closed container, protected from light, and stored at a temperature between 2 and 8?C. Additional information: Vincristine sulfate is hygroscopic and very toxic. CAUTION: Vincristine sulfate must be handled with care, avoiding contact with the skin and inhalation of airborne particles. Definition: Vincristine sulfate contains not less than 95.0% and not more than 105.0% of C46H56N4O10,H2SO4, calculated with reference to the dried substance.

DRUG BANK

DBSALT000314

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

NCI_THESAURUS

C1739

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

DAILYMED

T5IRO3534A

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

RS_ITEM_NUM

1714007

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

SMS_ID

100000091361

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

EVMPD

SUB05101MIG

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

CHEBI

79401

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

CAS

2068-78-2

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

FDA UNII

T5IRO3534A

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

HSDB

2068-78-2

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

ChEMBL

CHEMBL90555

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

NSC

67574

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

RXCUI

11203

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

ECHA (EC/EINECS)

218-190-0

Created by admin on Fri Dec 15 15:00:13 UTC 2023 , Edited by admin on Fri Dec 15 15:00:13 UTC 2023

PRIMARY

Related Record Type Details


					5J49Q6B70F

PARENT -> SALT/SOLVATE

VINCRISTINE SULFATE LIPOSOME

SUB_CONCEPT->SUBSTANCE

Related Record Type Details


					803MS59U85

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					YVA84573TN

4-DEACETYLVINCRISTINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					5V9KLZ54CY

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					2Q5SB43WZ2

4-DEACETYLVINBLASTINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					6XU5ZX7TRP

4'-DEOXYLEUROCRISTINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					I4U9NZS9T5

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					ER7ATN96R8

1-DEMETHYLVINCALEUKOBLASTINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

Related Record Type Details


					5J49Q6B70F

ACTIVE MOIETY