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Details

Stereochemistry ACHIRAL
Molecular Formula C9H7Cl2N5
Molecular Weight 256.091
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LAMOTRIGINE

SMILES

NC1=NC(N)=C(N=N1)C2=C(Cl)C(Cl)=CC=C2

InChI

InChIKey=PYZRQGJRPPTADH-UHFFFAOYSA-N
InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)

HIDE SMILES / InChI
Molecular Formula C9H7Cl2N5
Molecular Weight 256.091
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:15:28 UTC 2023
Edited
by admin
on Fri Dec 15 15:15:28 UTC 2023
Record UNII
U3H27498KS
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LAMOTRIGINE
EP   HSDB   INN   JAN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
INN   USAN  
Official Name English
LAMOTRIGINE [HSDB]
Common Name English
LAMICTAL
Brand Name English
LAMOTRIGINE [JAN]
Common Name English
LAMOTRIGINE [MART.]
Common Name English
lamotrigine [INN]
Common Name English
1,2,4-TRIAZINE-3,5-DIAMINE, 6-(2,3-DICHLOROPHENYL)
Common Name English
LAMOTRIGINE [EP MONOGRAPH]
Common Name English
LAMOTRIGINE [MI]
Common Name English
BW-430C
Code English
Lamotrigine [WHO-DD]
Common Name English
LAMOTRIGINE [ORANGE BOOK]
Common Name English
LAMOTRIGINE [EP IMPURITY]
Common Name English
LAMOTRIGINE [USP-RS]
Common Name English
LAMOTRIGINE [USP MONOGRAPH]
Common Name English
LAMOTRIGINE [USAN]
Common Name English
LAMOTRIGINE [USP IMPURITY]
Common Name English
3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine
Common Name English
BW 430C
Code English
NSC-759171
Code English
Classification Tree Code System Code
NDF-RT N0000175753
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
NDF-RT N0000175751
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
FDA ORPHAN DRUG 91695
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
WHO-ATC N03AX09
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
WHO-VATC QN03AX09
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
NCI_THESAURUS C264
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
NDF-RT N0000008486
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
LIVERTOX NBK548562
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
Code System Code Type Description
PUBCHEM
3878
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
DAILYMED
U3H27498KS
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
ECHA (EC/EINECS)
281-901-8
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
USAN
X-44
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
INN
5638
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
IUPHAR
2622
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
DRUG CENTRAL
1540
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
RS_ITEM_NUM
1356756
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
CAS
84057-84-1
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
RXCUI
28439
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY RxNorm
HSDB
7526
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
NCI_THESAURUS
C38703
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
EPA CompTox
DTXSID2023195
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
EVMPD
SUB08393MIG
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
LACTMED
Lamotrigine
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
MESH
C047781
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
NSC
759171
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
CHEBI
6367
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
SMS_ID
100000092282
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
MERCK INDEX
m6673
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY Merck Index
DRUG BANK
DB00555
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
WIKIPEDIA
LAMOTRIGINE
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
FDA UNII
U3H27498KS
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
ChEMBL
CHEMBL741
Created by admin on Fri Dec 15 15:15:28 UTC 2023 , Edited by admin on Fri Dec 15 15:15:28 UTC 2023
PRIMARY
Related Record Type Details
Structure of LAMOTRIGINE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
USP
SODIUM CHANNEL PROTEIN TYPE 1 SUBUNIT ALPHA
TARGET -> INHIBITOR
Binds to inactivated state and prevents activation
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
SODIUM CHANNEL PROTEIN TYPE 8 SUBUNIT ALPHA
TARGET -> INHIBITOR
Binds to inactivated state and prevents activation
SODIUM CHANNEL PROTEIN TYPE 3 SUBUNIT ALPHA
TARGET -> INHIBITOR
Binds to inactivated state and prevents activation
SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA
TARGET -> INHIBITOR
Binds to inactivated state and prevents activation
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A4
METABOLIC ENZYME -> SUBSTRATE
Related Record Type Details
Structure of LAMOTRIGINE N5-GLUCURONIDE
METABOLITE -> PARENT
10% of dose
MINOR
URINE
Structure of N2-METHYL LAMOTRIGINE
METABOLITE -> PARENT
URINE
Structure of LAMOTRIGINE N2-OXIDE
METABOLITE -> PARENT
0-5% of dose
URINE
Structure of N2-METHYL LAMOTRIGINE
METABOLITE -> PARENT
trace amount
Structure of LAMOTRIGINE N2-GLUCURONIDE
METABOLITE -> PARENT
80-90% of dose
MAJOR
URINE
Structure of Lamotrigine 2-N-glucuronide
METABOLITE INACTIVE -> PARENT
MAJOR
Related Record Type Details
Structure of 3-AMINO-6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZIN-5(4H)-ONE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 3-AMINO-6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZIN-5(4H)-ONE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (GC)
EP
Structure of N-(5-AMINO-6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZIN-3-YL)-2,3-DICHLOROBENZAMIDE
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.3
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE
IMPURITY -> PARENT
UNSPECIFIED
EP
Structure of LAMOTRIGINE 3,3-DIMER
IMPURITY -> PARENT
Structure of 2,3-DICHLOROBENZOIC ACID
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 6-(2,4-DICHLOROPHENYL)-1,2,4-TRIAZINE-3,5-DIAMINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of (2,3-DICHLOROPHENYL)(GUANIDINYLIMINO)ACETONITRILE, (Z)-
IMPURITY -> PARENT
UNSPECIFIED
EP
Structure of (2,3-DICHLOROPHENYL)(GUANIDINYLIMINO)ACETONITRILE, (E)-
IMPURITY -> PARENT
UNSPECIFIED
EP
Structure of N-(5-AMINO-6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZIN-3-YL)-2,3-DICHLOROBENZAMIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Related Record Type Details
Structure of LAMOTRIGINE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
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