U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Wed Apr 02 02:30:09 GMT 2025
Edited
by admin
on Wed Apr 02 02:30:09 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
PIV978KC1N
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NAC1
Preferred Name English
SODIUM CHANNEL PROTEIN TYPE 1 SUBUNIT ALPHA
Common Name English
SCN1A Protein
Common Name English
SODIUM CHANNEL PROTEIN BRAIN I SUBUNIT ALPHA
Common Name English
SCN1
Common Name English
VOLTAGE-GATED SODIUM CHANNEL SUBUNIT ALPHA NAV1.1
Common Name English
NAV 1.1
Common Name English
SODIUM CHANNEL PROTEIN TYPE I SUBUNIT ALPHA
Common Name English
Code System Code Type Description
UNIPROT
P35498
Created by admin on Wed Apr 02 02:30:09 GMT 2025 , Edited by admin on Wed Apr 02 02:30:09 GMT 2025
PRIMARY
FDA UNII
PIV978KC1N
Created by admin on Wed Apr 02 02:30:09 GMT 2025 , Edited by admin on Wed Apr 02 02:30:09 GMT 2025
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_211
N 1_284
N 1_295
N 1_301
N 1_306
N 1_338
N 1_1378
N 1_1392
N 1_1403
Related Record Type Details
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
Anti-convulsant effect with no relation to its anti-inflammatory properties. Same mode of action as seen with diphenylhydratoin and carbamazepine. Target assumed from similarity with
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Shifts hNav1.1 opening to more depolarized voltages without further alterations in the gating properties of hNav1.1, hNav1.2, hNav1.3, and hNav1.6;
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Binds to inactivated state and prevents activation
INHIBITOR -> TARGET
INHIBITOR -> TARGET
EC50
INHIBITOR -> TARGET
Inhibits other VGSC channels.
INDUCER OF EXPRESSION->TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_1516] DEXFOSFOSERINE VI4F0K069V
AMINO ACID SUBSTITUTION [1_470] [1_523] [1_525] [1_550] [1_551] [1_607] [1_730] DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL