Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Wed Apr 02 02:30:09 GMT 2025
by
admin
on
Wed Apr 02 02:30:09 GMT 2025
|
| Protein Sub Type | |
| Sequence Type | COMPLETE |
| Record UNII |
PIV978KC1N
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
P35498
Created by
admin on Wed Apr 02 02:30:09 GMT 2025 , Edited by admin on Wed Apr 02 02:30:09 GMT 2025
|
PRIMARY | |||
|
PIV978KC1N
Created by
admin on Wed Apr 02 02:30:09 GMT 2025 , Edited by admin on Wed Apr 02 02:30:09 GMT 2025
|
PRIMARY |
| Glycosylation Type | HUMAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_211 |
| N | 1_284 |
| N | 1_295 |
| N | 1_301 |
| N | 1_306 |
| N | 1_338 |
| N | 1_1378 |
| N | 1_1392 |
| N | 1_1403 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
INHIBITOR -> TARGET |
IC50
|
||
|
INHIBITOR -> TARGET |
Anti-convulsant effect with no relation to its anti-inflammatory properties. Same mode of action as seen with diphenylhydratoin and carbamazepine. Target assumed from similarity with
|
||
|
|
INHIBITOR -> TARGET |
|
||
|
|
INHIBITOR -> TARGET |
|
||
|
INHIBITOR -> TARGET |
Shifts hNav1.1 opening to more depolarized voltages without further alterations in the gating properties of hNav1.1, hNav1.2, hNav1.3, and hNav1.6;
|
||
|
|
INHIBITOR -> TARGET |
|
||
|
|
INHIBITOR -> TARGET |
|
||
|
INHIBITOR -> TARGET | |||
|
INHIBITOR -> TARGET |
Binds to inactivated state and prevents activation
|
||
|
|
INHIBITOR -> TARGET |
|
||
|
INHIBITOR -> TARGET |
EC50
|
||
|
INHIBITOR -> TARGET |
Inhibits other VGSC channels.
|
||
|
INDUCER OF EXPRESSION->TARGET |
|
Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| AMINO ACID SUBSTITUTION | [1_1516] | DEXFOSFOSERINE | VI4F0K069V | |||
| AMINO ACID SUBSTITUTION | [1_470] [1_523] [1_525] [1_550] [1_551] [1_607] [1_730] | DEXFOSFOSERINE | VI4F0K069V |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
|
||||
| Molecular Formula | CHEMICAL |
|