U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Wed Apr 02 17:09:39 GMT 2025
Edited
by admin
on Wed Apr 02 17:09:39 GMT 2025
Protein Type BISPECIFIC ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
UC2FX6YY3P
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Immunoglobulin G1 [de-448-lysine], anti-(human epidermal growth factor receptor) (human-mouse monoclonal C225 ?1-chain) fusion protein with peptide linker (GGGGS)2 fusion protein with immunoglobulin anti-(human epidermal growth factor receptor HER3) (hum
Preferred Name English
Izalontamab Brengitecan
INN   USAN  
Official Name English
BL-B01D1
Code English
Immunoglobulin G1-scFv_L-kappa dimer, anti-[Homo sapiens EGFR (epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB)] and anti-[Homo sapiens ERBB3 (receptor tyrosine protein kinase erbB-3, HER3)], chimeric a
Common Name English
IZALONTAMAB BRENGITECAN [USAN]
Common Name English
BMS-986507
Code English
BMS986507
Code English
izalontamab brengitecan [INN]
Common Name English
Fused G1-scFv heavy-lambda heavy chain chimeric and Homo sapiens (1-702) [gamma1 heavy chain anti-EGFR chimeric (1-448) [VH (Mus musculus IGHV2-2*03 (93.8%) -(IGHD) -IGHJ3*01 (92.9%) A128>S (119), CDR-IMGT [8.7.13] (26-33.51-57.96-108)) (1-119) -Homo sap
Common Name English
Code System Code Type Description
INN
12678
Created by admin on Wed Apr 02 17:09:39 GMT 2025 , Edited by admin on Wed Apr 02 17:09:39 GMT 2025
PRIMARY
NCI_THESAURUS
C203048
Created by admin on Wed Apr 02 17:09:39 GMT 2025 , Edited by admin on Wed Apr 02 17:09:39 GMT 2025
PRIMARY
CAS
2760528-47-8
Created by admin on Wed Apr 02 17:09:39 GMT 2025 , Edited by admin on Wed Apr 02 17:09:39 GMT 2025
PRIMARY
SMS_ID
300000052411
Created by admin on Wed Apr 02 17:09:39 GMT 2025 , Edited by admin on Wed Apr 02 17:09:39 GMT 2025
PRIMARY
FDA UNII
UC2FX6YY3P
Created by admin on Wed Apr 02 17:09:39 GMT 2025 , Edited by admin on Wed Apr 02 17:09:39 GMT 2025
PRIMARY
USAN
MN-275
Created by admin on Wed Apr 02 17:09:39 GMT 2025 , Edited by admin on Wed Apr 02 17:09:39 GMT 2025
PRIMARY
From To
4_134 4_194
4_23 4_88
3_134 3_194
3_23 3_88
2_613 2_681
2_480 2_554
2_369 2_427
2_263 2_323
2_222 4_214
2_146 2_202
2_22 2_95
1_613 1_681
1_480 1_554
1_369 1_427
1_263 1_323
1_222 3_214
1_231 2_231
1_228 2_228
1_146 1_202
1_22 1_95
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_88
N 1_299
N 2_88
N 2_299
Related Record Type Details
PARENT -> CONJUGATE
TARGET -> INHIBITOR
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION RESIDUE_SPECIFIC C Amount: UNSPECIFIED SUBSTANCE
97a279ed
(not in database)
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL