Usual Adult Dose for Anesthesia Preanesthetic (reduction of secretions): 0.004 mg (0.02 mL)/kg IM 30 to 60 minutes prior to the anticipated time of induction of anesthesia or at the time the preanesthetic narcotic and/or sedative are administered. Intraoperative: 0.1 mg (0.5 mL) IV repeated as needed every 2 to 3 minutes. Reversal of neuromuscular blockade: 0.2 mg (1.0 mL) IV for each 1.0 mg of neostigmine or 5 mg of pyridostigmine. Reversal of bradycardia, vagal reflexes (intraoperative): 0.1 mg IV repeated as needed at 2 to 3 minute intervals. Usual Adult Dose for Peptic Ulcer Parenteral: 0.1 mg (0.5 mL) IV or IM every 4 hours, 3 to 4 times daily. If a more profound effect is required the dose may be increased to 0.2 mg (1 mL). 1 mg oral tablet: Initial dose: 1 mg orally 3 times daily or 1 mg in the morning, 1 mg in the early afternoon, and 2 mg at bedtime. Maintenance dose: 1 mg orally twice daily to a maximum of 8 mg per day. 2 mg oral tablet: 2 mg orally 2 to 3 times daily to a maximum of 8 mg per day. 1.5 mg oral tablet: Used to provide intermediate titration doses based on patient response. Usual Pediatric Dose for Anesthesia Preanesthetic: 0.004 mg (0.02 mL)/kg IM 30 to 60 minutes prior to the anticipated time of induction of anesthesia or at the time the preanesthetic narcotic and/or sedative are administered. Children under 2 years of age may require up to 0.009 mg (0.45 mL)/kg. Intraoperative: 0.004 mg (0.02 mL)/kg IV not to exceed 0.1 mg (0.5 mL) in a single dose, repeated as needed every 2 to 3 minutes. Reversal of neuromuscular blockade: 0.4 mg (2 mL)/kg IV for each 1 mg of neostigmine or 5 mg of pyridostigmine. Reversal of bradycardia, vagal reflexes (intraoperative): 4 mcg/kg/dose IV (maximum dose: 100 mcg/dose) at 2 to 3 minute intervals. Usual Pediatric Dose for Excessive Salivation 3 years to 16 years with neurologic conditions associated with problem drooling: Initiate dosing at 0.02 mg/kg orally three times daily and titrate in increments of 0.02 mg/kg every 5 to 7 days, based on therapeutic response and adverse reactions. Maximum recommended dose is 0.1 mg/kg three times daily, not to exceed 1.5 to 3 mg per dose based upon weight. Administer at least one hour before or two hours after meals.

Glycopyrrolate inhibited contraction induced by EFS (40 V, 0.5 ms, 4 Hz for 15 s every 4 min) in guinea-pig trachea in a concentration-dependent manner (IC50=0.15 nM, n=5 ± 12). Glycopyrrolate inhibited contraction induced by EFS (40 V, 0.5 ms, 8 Hz for 15 s every 4 min) in human trachea in a concentration-dependent manner (IC50=0.44 nM, n=3 ± 8).