MUSCARINIC ACETYLCHOLINE RECEPTOR M3

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 16:45:34 GMT 2025` Edited by `admin` on `Tue Apr 01 16:45:34 GMT 2025`
Protein Type	RECEPTOR
Protein Sub Type	ACETYLCHOLINE RECEPTOR
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	W3JX5KZ4V2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MUSCARINIC ACETYLCHOLINE RECEPTOR M3

Common Name

English

CHRM3

Preferred Name

English

acetylcholine receptor, muscarinic 3

Common Name

English

M3 Human Acetylcholine (Muscarinic) Receptor

Common Name

English

Common Name

English

Code System Code Type Description

FDA UNII

W3JX5KZ4V2

Created by admin on Tue Apr 01 16:45:34 GMT 2025 , Edited by admin on Tue Apr 01 16:45:34 GMT 2025

PRIMARY

UNIPROT

P20309

Created by admin on Tue Apr 01 16:45:34 GMT 2025 , Edited by admin on Tue Apr 01 16:45:34 GMT 2025

PRIMARY

PHAROS

P20309

Created by admin on Tue Apr 01 16:45:34 GMT 2025 , Edited by admin on Tue Apr 01 16:45:34 GMT 2025

PRIMARY

From	To
1_141	1_221
1_517	1_520

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_5
N	1_6
N	1_15
N	1_41
N	1_48

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CHF-6366 muscarinic metabolite

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REVEFENACIN

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Comments:

In the airways, it exhibits pharmacological effects through inhibition of M3 receptor at the smooth muscle leading to bronchodilation.

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BINDING

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Amount:


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S-ISOMER BINDS WITH LESS AVIDITY

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SOFPIRONIUM

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NAVAFENTEROL

INHIBITOR -> TARGET

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AF-DX-384

INHIBITOR -> TARGET

Qualification:

Amount:


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ATROPINE

INHIBITOR -> TARGET

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BINDING

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IC50

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METHOCTRAMINE FREE BASE

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Comments:

Membranes from transfected CHO cells

Interaction Type:

BINDING

Qualification:

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Amount:


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INHIBITOR -> TARGET

Amount:


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VELUFENACIN

INHIBITOR -> TARGET

Interaction Type:

BINDING

Qualification:

IC50

Amount:


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Comments:

Increases the binding affinity of acetylcholine to receptor.

Amount:


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METHACHOLINE

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Amount:


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ESPATROPATE

INHIBITOR -> TARGET

Amount:


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INHIBITOR -> TARGET

Comments:

THRX-195518 possesses activity at target muscarinic receptors that was slightly lower (approximately one-third to one-tenth) than revefenacin.

Interaction Type:

BINDING

Qualification:

Amount:


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NERATINIB

INHIBITOR->OFF-TARGET

Comments:

Radioligand binding assay

Interaction Type:

BINDING

Qualification:

IC50

Amount:


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XANOMELINE

AGONIST -> TARGET

Amount:


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RISPERIDONE

NON-INHIBITOR->OFF-TARGET

Amount:


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TOLTERODINE

INHIBITOR -> TARGET

Amount:


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PF-03635659

INHIBITOR -> TARGET

Amount:


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Amount:


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INHIBITOR -> TARGET

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Qualification:

Amount:


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INHIBITOR -> TARGET

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IC50

Amount:


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INHIBITOR -> TARGET

Qualification:

Amount:


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AGONIST -> TARGET

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_385]				DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL
Molecular Formula	CHEMICAL