Becotatug Vedotin

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 14:21:39 GMT 2025` Edited by `admin` on `Wed Apr 02 14:21:39 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1\|TOXIN CONJUGATE
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	VHA6L8H5FM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Becotatug Vedotin

Official Name

English

MRG-003

Preferred Name

English

Anti-EGFR Antibody-drug Conjugate MRG003

Common Name

English

MRG003

Code

English

Immunoglobulin G1-kappa, anti-[Homo sapiens EGFR (epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB)], humanized monoclonal antibody, conjugated on an average of four cysteinyl residues to vedotin, compri

Common Name

English

H-gamma1 heavy chain humanized (1-449) [VH (Homo sapiens IGHV4-4*08 (79.4%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.7.13] (26-33.51-57.96-108)) (1-119) -Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 (CH1 R120 (216) (120-217), hinge 1-15 (218-232), CH2 (233-342

Common Name

English

antibody drug conjugate (ADC) composed of a recombinant humanized anti-human Epidermal growth factor receptor (EGFR) monoclonal antibody JMT101 conjugated with the cytotoxic small molecule MMAE

Common Name

English

Recombinant humanized anti-human epidermal growth factor receptor monoclonal antibody conjugated to monomethyl auristatin E

Common Name

English

Anti-EGFR ADC MRG003

Common Name

English

becotatug vedotin [INN]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

899622