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Details

Stereochemistry ACHIRAL
Molecular Formula C29H28N2O7
Molecular Weight 516.5418
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MURAGLITAZAR

SMILES

COC1=CC=C(OC(=O)N(CC(O)=O)CC2=CC=C(OCCC3=C(C)OC(=N3)C4=CC=CC=C4)C=C2)C=C1

InChI

InChIKey=IRLWJILLXJGJTD-UHFFFAOYSA-N
InChI=1S/C29H28N2O7/c1-20-26(30-28(37-20)22-6-4-3-5-7-22)16-17-36-24-10-8-21(9-11-24)18-31(19-27(32)33)29(34)38-25-14-12-23(35-2)13-15-25/h3-15H,16-19H2,1-2H3,(H,32,33)

HIDE SMILES / InChI
Molecular Formula C29H28N2O7
Molecular Weight 516.5418
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:53:05 UTC 2023
Edited
by admin
on Fri Dec 15 15:53:05 UTC 2023
Record UNII
W1MKM70WQI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MURAGLITAZAR
INN   MART.   MI   USAN   WHO-DD  
USAN   INN  
Official Name English
MURAGLITAZAR [USAN]
Common Name English
BMS-298585
Code English
MURAGLITAZAR [MART.]
Common Name English
muraglitazar [INN]
Common Name English
[[(4-Methoxyphenoxy)carbonyl][4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]benzyl]amino]acetic acid
Systematic Name English
BMS-298585-01
Code English
N-((4-METHOXYPHENOXY)CARBONYL)-N-((4-(2-(5-METHYL-2-PHENYL-4-OXAZOLYL)ETHOXY)PHENYL)-METHYL)GLYCINE
Systematic Name English
MURAGLITAZAR [MI]
Common Name English
GLYCINE, N-((4-METHOXYPHENOXY)CARBONYL)-N-((4-(2-(5-METHYL-2-PHENYL-4-OXAZOLYL)ETHOXY)PHENYL)METHYL)-
Systematic Name English
Muraglitazar [WHO-DD]
Common Name English
MK-0478
Code English
MK0478
Code English
Classification Tree Code System Code
NCI_THESAURUS C98233
Created by admin on Fri Dec 15 15:53:05 UTC 2023 , Edited by admin on Fri Dec 15 15:53:05 UTC 2023
Code System Code Type Description
EVMPD
SUB21507
Created by admin on Fri Dec 15 15:53:05 UTC 2023 , Edited by admin on Fri Dec 15 15:53:05 UTC 2023
PRIMARY
FDA UNII
W1MKM70WQI
Created by admin on Fri Dec 15 15:53:05 UTC 2023 , Edited by admin on Fri Dec 15 15:53:05 UTC 2023
PRIMARY
ChEMBL
CHEMBL186179
Created by admin on Fri Dec 15 15:53:05 UTC 2023 , Edited by admin on Fri Dec 15 15:53:05 UTC 2023
PRIMARY
INN
8442
Created by admin on Fri Dec 15 15:53:05 UTC 2023 , Edited by admin on Fri Dec 15 15:53:05 UTC 2023
PRIMARY
USAN
PP-02
Created by admin on Fri Dec 15 15:53:05 UTC 2023 , Edited by admin on Fri Dec 15 15:53:05 UTC 2023
PRIMARY
WIKIPEDIA
MURAGLITAZAR
Created by admin on Fri Dec 15 15:53:05 UTC 2023 , Edited by admin on Fri Dec 15 15:53:05 UTC 2023
PRIMARY
CAS
331741-94-7
Created by admin on Fri Dec 15 15:53:05 UTC 2023 , Edited by admin on Fri Dec 15 15:53:05 UTC 2023
PRIMARY
DRUG BANK
DB06510
Created by admin on Fri Dec 15 15:53:05 UTC 2023 , Edited by admin on Fri Dec 15 15:53:05 UTC 2023
PRIMARY
SMS_ID
100000088312
Created by admin on Fri Dec 15 15:53:05 UTC 2023 , Edited by admin on Fri Dec 15 15:53:05 UTC 2023
PRIMARY
EPA CompTox
DTXSID9057719
Created by admin on Fri Dec 15 15:53:05 UTC 2023 , Edited by admin on Fri Dec 15 15:53:05 UTC 2023
PRIMARY
PUBCHEM
206044
Created by admin on Fri Dec 15 15:53:05 UTC 2023 , Edited by admin on Fri Dec 15 15:53:05 UTC 2023
PRIMARY
MERCK INDEX
m1210
Created by admin on Fri Dec 15 15:53:05 UTC 2023 , Edited by admin on Fri Dec 15 15:53:05 UTC 2023
PRIMARY Merck Index
NCI_THESAURUS
C75190
Created by admin on Fri Dec 15 15:53:05 UTC 2023 , Edited by admin on Fri Dec 15 15:53:05 UTC 2023
PRIMARY
MESH
C500085
Created by admin on Fri Dec 15 15:53:05 UTC 2023 , Edited by admin on Fri Dec 15 15:53:05 UTC 2023
PRIMARY
Related Record Type Details
Structure of MURAGLITAZAR
EXCRETED UNCHANGED
FECAL
PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA
TARGET -> AGONIST
Structure of MURAGLITAZAR
EXCRETED UNCHANGED
URINE
PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
TARGET -> AGONIST
Related Record Type Details
Structure of 12-HYDROXY-O-DEMETHYL MURAGLITAZAR
METABOLITE -> PARENT
PLASMA
Structure of N-((4-HYDROXYPHENYL)METHYL)-N-((4-METHOXYPHENOXY)CARBONYL)GLYCINE
METABOLITE -> PARENT
PLASMA
Structure of 17-HYDROXY-O-DEMETHYL MURAGLITAZAR
METABOLITE -> PARENT
FECAL
Structure of MURAGLITAZAR-17-HYDROXYGLUCURONIDE
METABOLITE -> PARENT
PLASMA, BILE
Structure of 8,12-DIHYDROXY MURAGLITAZAR
METABOLITE -> PARENT
FECAL
Structure of MURAGLITAZAR 12-CARBOXYLIC ACID
METABOLITE -> PARENT
PLASMA
Structure of GLYCINE, N-((4-(3-(ACETYLBENZOYLAMINO)-3-OXOPROPOXY)PHENYL)METHYL)-N-((4-METHOXYPHENOXY)CARBONYL)-
METABOLITE -> PARENT
FECAL
Structure of MURAGLITAZAR GLUCURONIDE
METABOLITE -> PARENT
PLASMA
Structure of O-DEMETHYL MURAGLITAZAR GLUCURONIDE
METABOLITE -> PARENT
BILE
Structure of GLYCINE, N-((4-HYDROXYPHENOXY)CARBONYL)-N-((4-HYDROXYPHENYL)METHYL)-
METABOLITE -> PARENT
FECAL
Structure of 8-HYDROXY MURAGLITAZAR
METABOLITE -> PARENT
TRACE AMOUNT
PLASMA
Structure of GLYCINE, N-((4-(3-(BENZOYLAMINO)-3-OXOPROPOXY)PHENYL)METHYL)-N-((4-METHOXYPHENOXY)CARBONYL)-
METABOLITE -> PARENT
FECAL
Structure of 12,17-DIHYDROXY MURAGLITAZAR
METABOLITE -> PARENT
FECAL
Structure of O-DEMETHYL MURAGLITAZAR 17-HYDROXYGLUCURONIDE
METABOLITE -> PARENT
URINE, BILE
Structure of O-DEMETHYL MURAGLITAZAR
METABOLITE -> PARENT
PLASMA
Structure of 9-HYDROXY MURAGLITAZAR
METABOLITE -> PARENT
FECAL
Structure of 12-HYDROXY MURAGLITAZAR
METABOLITE -> PARENT
FECAL
Structure of 17-HYDROXY MURAGLITAZAR
METABOLITE -> PARENT
FECAL
Structure of 9,12-DIHYDROXY MURAGLITAZAR
METABOLITE -> PARENT
FECAL
Structure of 8-HYDROXY-O-DEMETHYL MURAGLITAZAR
METABOLITE -> PARENT
at 4h
TRACE AMOUNT
PLASMA
Structure of 9-HYDROXYO-DEMETHYL MURAGLITAZAR
METABOLITE -> PARENT
FECAL
Related Record Type Details
Structure of MURAGLITAZAR
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC ORAL ADMINISTRATION

Tmax PHARMACOKINETIC ORAL ADMINISTRATION

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