UK-390957

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H20N2O3S2
Molecular Weight	352.472
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CSC1=CC=C(OC2=CC=C(C=C2CN(C)C)S(N)(=O)=O)C=C1

InChI

InChIKey=VCNSPGHSQPMCFF-UHFFFAOYSA-N

InChI=1S/C16H20N2O3S2/c1-18(2)11-12-10-15(23(17,19)20)8-9-16(12)21-13-4-6-14(22-3)7-5-13/h4-10H,11H2,1-3H3,(H2,17,19,20)

HIDE SMILES / InChI

Molecular Formula	C16H20N2O3S2
Molecular Weight	352.472
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800017934 | https://www.ncbi.nlm.nih.gov/pubmed/19412497

UK-390957 is a selective serotonin reuptake inhibitor (SSRI) that was in phase II/III development in the USA, European Union and other territories with Pfizer, for the treatment of Premature ejaculation. UK-390957 represented a major development in sexual medicine, and offered patients the convenience of on-demand dosing, significant improvements in IELT, ejaculatory control, and sexual satisfaction with minimal adverse effects. However development of UK-390957 was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Measurement of binding of basic drugs to acidic phospholipids using surface plasmon resonance and incorporation of the data into mechanistic tissue composition equations to predict steady-state volume of distribution.	2011-10	21764943
New agents in the treatment of premature ejaculation.	2006-12	19412497

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

In Vitro Use Guide

UK-390957 inhibited [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells with IC50 value of 4 nM.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:55:24 GMT 2025` Edited by `admin` on `Mon Mar 31 17:55:24 GMT 2025`
Record UNII	W26I0D1D6J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

UK-390957

Common Name

English

UK-390,957

Preferred Name

English

3-DIMETHYLAMINOMETHYL-4-(4-METHYLSULFANYL-PHENOXY)-BENZENESULFONAMIDE

Systematic Name

English

Code System Code Type Description

PUBCHEM

9884876