RUFINAMIDE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H8F2N4O
Molecular Weight	238.1935
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of RUFINAMIDE

Structure Search

SMILES

NC(=O)C1=CN(CC2=C(F)C=CC=C2F)N=N1

InChI

InChIKey=POGQSBRIGCQNEG-UHFFFAOYSA-N

InChI=1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17)

HIDE SMILES / InChI

Molecular Formula	C10H8F2N4O
Molecular Weight	238.1935
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:38:26 UTC 2023` Edited by `admin` on `Fri Dec 15 15:38:26 UTC 2023`
Record UNII	WFW942PR79
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

RUFINAMIDE

Official Name

English

1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide

Systematic Name

English

1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE, 1-((2,6-DIFLUOROPHENYL)METHYL)-

Systematic Name

English

RUFINAMIDE [ORANGE BOOK]

Common Name

English

RUFINAMIDE [JAN]

Common Name

English

INOVELON

Brand Name

English

RUFINAMIDE [MART.]

Common Name

English

RUF 331

Code

English

RUFINAMIDE [EMA EPAR]

Common Name

English

CGP 33101

Code

English

E-2080

Code

English

Rufinamide [WHO-DD]

Common Name

English

CGP-33101

Code

English

RUFINAMIDE [VANDF]

Common Name

English

RUFINAMIDE [USP MONOGRAPH]

Common Name

English

RUF-331

Code

English

60231/4

Code

English

RUFINAMIDE [MI]

Common Name

English

E2080

Code

English

RUFINAMIDE [USP-RS]

Common Name

English

RUFINAMIDE [USAN]

Common Name

English

rufinamide [INN]

Common Name

English

BANZEL

Brand Name

English

Classification Tree Code System Code

WHO-ATC

N03AF03

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

NCI_THESAURUS

C264

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

WHO-VATC

QN03AF03

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

LIVERTOX

NBK548457

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

EU-Orphan Drug

EU/3/04/240

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

EMA ASSESSMENT REPORTS

INOVELON (AUTHORIZED: EPILEPSY)

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

FDA ORPHAN DRUG

193504

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

Code System Code Type Description

MESH

C079703

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

INN

7387

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

WIKIPEDIA

RUFINAMIDE

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

CAS

106308-44-5

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

FDA UNII

WFW942PR79

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

PUBCHEM

129228

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

IUPHAR

7470

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

EVMPD

SUB10403MIG

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

DAILYMED

WFW942PR79

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

ChEMBL

CHEMBL1201754

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

RXCUI

69036

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

RxNorm

LACTMED

Rufinamide

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

SMS_ID

100000089186

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

MERCK INDEX

m9696

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

Merck Index

RS_ITEM_NUM

1606401

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

NCI_THESAURUS

C75167

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

USAN

SS-30

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

DRUG BANK

DB06201

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

EPA CompTox

DTXSID1046506

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

DRUG CENTRAL

3534

Created by admin on Fri Dec 15 15:38:27 UTC 2023 , Edited by admin on Fri Dec 15 15:38:27 UTC 2023

PRIMARY

Related Record Type Details


					03BYF220B6

CYTOCHROME P450 2E1

METABOLIC ENZYME -> INHIBITOR

Qualification:

Ki

Amount:


					WFW942PR79

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (HPLC)

Qualification:

USP

Amount:


					WFW942PR79

EXCRETED UNCHANGED

Qualification:

FECAL; URINE

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> INDUCER

Interaction Type:

WEAK

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					PIV978KC1N

SODIUM CHANNEL PROTEIN TYPE 1 SUBUNIT ALPHA

TARGET -> INHIBITOR

Comments:

Shifts hNav1.1 opening to more depolarized voltages without further alterations in the gating properties of hNav1.1, hNav1.2, hNav1.3, and hNav1.6;

Related Record Type Details

266244C47B

CGP-47292

METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

PLASMA

Amount:


					Y6SVR6RVU4

.BETA.-D-GLUCOPYRANURONIC ACID, 1-(1-((2,6-DIFLUOROPHENYL)METHYL)-1H-1,2,3-TRIAZOLE-4-CARBOXYLATE)

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

URINE

Related Record Type Details


					646E5NT95T

DESFLUORORUFINAMIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					Z9CM6FY6FA

RUFINAMIDE-5-CARBOXAMIDE

IMPURITY -> PARENT

Amount:


					6K1724ZSGB

CGP-47292 METHYL ESTER

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

Related Record Type Details


					WFW942PR79

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Tmax	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC

Volume of Distribution	PHARMACOKINETIC