SOFOSBUVIR

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H29FN3O9P
Molecular Weight	529.4525
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of SOFOSBUVIR

Structure Search

SMILES

CC(C)OC(=O)[C@H](C)N[P@](=O)(OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@](C)(F)[C@@H]1O)OC3=CC=CC=C3

InChI

InChIKey=TTZHDVOVKQGIBA-IQWMDFIBSA-N

InChI=1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C22H29FN3O9P
Molecular Weight	529.4525
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 6
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 20:27:35 UTC 2023` Edited by `admin` on `Fri Dec 15 20:27:35 UTC 2023`
Record UNII	WJ6CA3ZU8B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SOFOSBUVIR

Official Name

English

sofosbuvir [INN]

Common Name

English

SOFOSBUVIR [VANDF]

Common Name

English

HARVONI COMPONENT SOFOSBUVIR

Brand Name

English

EPCLUSA COMPONENT SOFOSBUVIR

Brand Name

English

GS-7977

Code

English

SOFOSBUVIR COMPONENT OF VOSEVI

Brand Name

English

L-ALANINE, N-((P(S),2'R)-2'-DEOXY-2'-FLUORO-2'-METHYL-P-PHENYL-5'-URIDYLYL)-, 1-METHYLETHYL ESTER

Common Name

English

SOFOSBUVIR [USAN]

Common Name

English

SOF

Common Name

English

SOVALDI

Brand Name

English

(S)-ISOPROPYL 2-((S)-(((2R,3R,4R,5R)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-FLUORO-3-HYDROXY-4-METHYLTETRAHYDROFURAN-2-YL)METHOXY)-(PHENOXY)PHOSPHORYLAMINO)PROPANOATE

Systematic Name

English

Sofosbuvir [WHO-DD]

Common Name

English

SOFOSBUVIR COMPONENT OF HARVONI

Brand Name

English

SOFOSBUVIR COMPONENT OF EPCLUSA

Brand Name

English

SOFOSBUVIR [MI]

Common Name

English

PSI-7977

Code

English

SOFOSBUVIR [ORANGE BOOK]

Common Name

English

GS7977

Code

English

VOSEVI COMPONENT SOFOSBUVIR

Brand Name

English

SOFOSBUVIR [JAN]

Common Name

English

Classification Tree Code System Code

WHO-ATC

J05AP55

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

NCI_THESAURUS

C281

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

WHO-ATC

J05AX65

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

WHO-ATC

J05AX15

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

FDA ORPHAN DRUG

535916

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

WHO-ATC

J05AP08

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

EMA ASSESSMENT REPORTS

SOVALDI (AUTHORIZED: HEPATITIS C, CHRONIC)

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

NDF-RT

N0000191493

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

NCI_THESAURUS

C25995

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

FDA ORPHAN DRUG

541716

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

WHO-ATC

J05AP51

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

FDA ORPHAN DRUG

554816

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

EMA ASSESSMENT REPORTS

HARVONI (AUTHORIZED: HEPATITIS C, CHRONIC)

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

WHO-ATC

J05AP56

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

Code System Code Type Description

EPA CompTox

DTXSID701027632

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

IUPHAR

7368

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

HSDB

8226

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

MERCK INDEX

m11680

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

DAILYMED

WJ6CA3ZU8B

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

SMS_ID

100000144530

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

WIKIPEDIA

SOFOSBUVIR

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

NCI_THESAURUS

C101263

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

INN

9665

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

DRUG BANK

DB08934

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

CHEBI

85083

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

CAS

1190307-88-0

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

NDF-RT

N0000191258

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

RNA Replicase Inhibitors [MoA]

RXCUI

1484911

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

RxNorm

FDA UNII

WJ6CA3ZU8B

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

ChEMBL

CHEMBL1259059

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

DRUG CENTRAL

4811

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

PUBCHEM

45375808

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

LACTMED

Sofosbuvir

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

EVMPD

SUB121170

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

USAN

XX-67

Created by admin on Fri Dec 15 20:27:36 UTC 2023 , Edited by admin on Fri Dec 15 20:27:36 UTC 2023

PRIMARY

Related Record Type Details


					SU59CZ8IUV

LYSOSOMAL PROTECTIVE PROTEIN

METABOLIC ENZYME -> SUBSTRATE


					HPN66MJEK8

LIVER CARBOXYLESTERASE 1

METABOLIC ENZYME -> SUBSTRATE


					VTC1801X29

HCV NS5B POLYMERASE

TARGET -> INHIBITOR


					3S5S1851OV

PSI-7851

EPIMER -> DIASTEREOISOMER


					WJ6CA3ZU8B

EXCRETED UNCHANGED

Qualification:

URINE

Amount:


					QI56415283

HEPATITIS C VIRUS

TARGET ORGANISM->INHIBITOR

Amount:


					44V7045CXS

RO-2433

EXCRETED UNCHANGED

Qualification:

URINE

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:

Related Record Type Details


					44V7045CXS

RO-2433

METABOLITE INACTIVE -> PARENT


					YQ33JQ8MWT

PSI-7410

METABOLITE -> PARENT


					OOL8KAC85O

PSI-7411

METABOLITE -> PARENT


					8C9Y1F217H

GS-566500

METABOLITE INACTIVE -> PARENT


					T90A75S60M

PSI-7409

METABOLITE ACTIVE -> PRODRUG

Interaction Type:

MINOR


					8C9Y1F217H

GS-566500

METABOLITE -> PARENT

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC

Tmax	PHARMACOKINETIC				ORAL ADMINISTRATION