ETEVRITAMAB

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National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 22:54:15 GMT 2025` Edited by `admin` on `Tue Apr 01 22:54:15 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	BISPECIFIC T CELL ENGAGER
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	WR4J8FV2SM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ETEVRITAMAB

Official Name

English

AMG-596

Preferred Name

English

ANTI-EGFRVIII/CD3 BITE ANTIBODY AMG 596

Common Name

English

IMMUNOGLOBULIN, BISPECIFIC, ANTI-(HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT III) (HUMAN MONOCLONAL EGFRVIII BISPECIFIC 1 SINGLE-CHAIN VARIABLE FRAGMENT VH1-(GGGGS)3-VL1) FUSION PROTEIN WITH PEPTIDE LINKER (GGGGS) FUSION PROTEIN WITH IMMUNOGLOBULIN A

Common Name

English

AMG596

Code

English

etevritamab [INN]

Common Name

English

IMMUNOGLOBULIN SCFV-SCFV, ANTI-(HOMO SAPIENS EGFR (EPIDERMAL GROWTH FACTOR RECEPTOR, RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1, ERBB1, HER1, HER-1, ERBB) VARIANT III (EGFRVIII)) AND ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON, LEU-4)), MONOCLONAL ANTIBODY SINGLE

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

634718

Created by admin on Tue Apr 01 22:54:15 GMT 2025 , Edited by admin on Tue Apr 01 22:54:15 GMT 2025

Code System Code Type Description

NCI_THESAURUS

C146824

Created by admin on Tue Apr 01 22:54:15 GMT 2025 , Edited by admin on Tue Apr 01 22:54:15 GMT 2025

PRIMARY

SMS_ID

300000032583

Created by admin on Tue Apr 01 22:54:15 GMT 2025 , Edited by admin on Tue Apr 01 22:54:15 GMT 2025

PRIMARY

INN

11418

Created by admin on Tue Apr 01 22:54:15 GMT 2025 , Edited by admin on Tue Apr 01 22:54:15 GMT 2025

PRIMARY

CAS

2329692-74-0

Created by admin on Tue Apr 01 22:54:15 GMT 2025 , Edited by admin on Tue Apr 01 22:54:15 GMT 2025

PRIMARY

FDA UNII

WR4J8FV2SM

Created by admin on Tue Apr 01 22:54:15 GMT 2025 , Edited by admin on Tue Apr 01 22:54:15 GMT 2025

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From	To
1_22	1_96
1_44	1_244
1_162	1_232
1_279	1_355
1_419	1_487

Related Record Type Details


					1U72JD9DDZ

T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN

TARGET -> ACTIVATOR

Amount:


					RO03J093CP

EPIDERMAL GROWTH FACTOR RECEPTOR

TARGET->LIGAND

Amount:

Related Record Type Details


					WR4J8FV2SM

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL