Prafnosbart

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 15:01:34 GMT 2025` Edited by `admin` on `Wed Apr 02 15:01:34 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	Y5293N85Q7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DS-6016a

Preferred Name

English

Prafnosbart

Official Name

English

Immunoglobulin G1, anti-(human activin receptor-like kinase 2) (human-Rattus norvegicus monoclonal DS-6016a ?1-chain), disulfide with human-Rattus norvegicus monoclonal DS-6016a ?-chain, dimer

Common Name

English

gamma1 heavy chain humanized (1-451) [VH humanized (Homo sapiens IGHV3-21*01 (88.7%) -(IGHD) -IGHJ4*01(93.3%), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) - Homo sapiens IGHG1*03, G1m3, nG1m1, G1v14 CH2 A1.3, A1.2 (CH1 R120 (218) (122-219), hinge 1-1

Common Name

English

prafnosbart [INN]

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens ACVR1 (activin A receptor type 1, ACVRLK2, ALK2, ACVR1A, SKR1)], humanized monoclonal antibody

Common Name

English

Code System Code Type Description

INN

12177

Created by admin on Wed Apr 02 15:01:34 GMT 2025 , Edited by admin on Wed Apr 02 15:01:34 GMT 2025

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FDA UNII

Y5293N85Q7

Created by admin on Wed Apr 02 15:01:34 GMT 2025 , Edited by admin on Wed Apr 02 15:01:34 GMT 2025

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SMS_ID

300000046862

Created by admin on Wed Apr 02 15:01:34 GMT 2025 , Edited by admin on Wed Apr 02 15:01:34 GMT 2025

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NCI_THESAURUS

C190498

Created by admin on Wed Apr 02 15:01:34 GMT 2025 , Edited by admin on Wed Apr 02 15:01:34 GMT 2025

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CAS

2566473-71-8

Created by admin on Wed Apr 02 15:01:34 GMT 2025 , Edited by admin on Wed Apr 02 15:01:34 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_148	2_204
2_224	4_214
2_265	2_325
1_148	1_204
2_371	2_429
3_23	3_87
3_134	3_194
4_23	4_87
4_134	4_194
1_224	3_214
1_230	2_230
1_233	2_233
1_265	1_325
1_371	1_429

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_301
N	2_301

Related Record Type Details


					SX1JPI95HB

ACTIVIN RECEPTOR TYPE-1

TARGET->LIGAND

Amount:

Related Record Type Details


					Y5293N85Q7

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_451] [2_451]	C-TERMINUS		Amount:	LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL