MACITENTAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H20Br2N6O4S
Molecular Weight	588.273
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MACITENTAN

Structure Search

SMILES

CCCNS(=O)(=O)NC1=NC=NC(OCCOC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3

InChI

InChIKey=JGCMEBMXRHSZKX-UHFFFAOYSA-N

InChI=1S/C19H20Br2N6O4S/c1-2-7-26-32(28,29)27-17-16(13-3-5-14(20)6-4-13)18(25-12-24-17)30-8-9-31-19-22-10-15(21)11-23-19/h3-6,10-12,26H,2,7-9H2,1H3,(H,24,25,27)

HIDE SMILES / InChI

Molecular Formula	C19H20Br2N6O4S
Molecular Weight	588.273
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:43:58 UTC 2023` Edited by `admin` on `Sat Dec 16 17:43:58 UTC 2023`
Record UNII	Z9K9Y9WMVL
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MACITENTAN

Official Name

English

MACITENTAN [VANDF]

Common Name

English

MACITENTAN [JAN]

Common Name

English

OPSUMIT

Brand Name

English

MACITENTAN [ORANGE BOOK]

Common Name

English

MACITENTAN [USAN]

Common Name

English

Macitentan [WHO-DD]

Common Name

English

ACT 064992

Code

English

MACITENTAN [MI]

Common Name

English

N-(5-(4-BROMOPHENYL)-6-(2-((5-BROMOPYRIMIDIN-2-YL)OXY)ETHOXY)PYRIMIDIN-4-YL)-N'-PROPYLSULFAMIDE

Systematic Name

English

N-(5-(4-BROMOPHENYL)-6-(2-((5-BROMOPYRIMIDIN-2-YL)OXI)ETHOXY)PYRIMIDIN-4-YL)-N'-PROPYLSULFURIC DIAMIDE

Common Name

English

ACT-064992

Code

English

SULFAMIDE, N-(5-(4-BROMOPHENYL)-6-(2-((5-BROMO-2-PYRIMIDINYL)OXY)ETHOXY)-4-PYRIMIDINYL)-N'-PROPYL-

Systematic Name

English

macitentan [INN]

Common Name

English

Classification Tree Code System Code

WHO-ATC

C02KX04

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

FDA ORPHAN DRUG

580117

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

EMA ASSESSMENT REPORTS

OPSUMIT (AUTHORIZED: HYPERTENSION, PULMONARY)

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

FDA ORPHAN DRUG

282209

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

WHO-VATC

QC02KX04

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

FDA ORPHAN DRUG

509615

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

FDA ORPHAN DRUG

574917

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

NDF-RT

N0000175581

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

FDA ORPHAN DRUG

279309

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

EU-Orphan Drug

EU/3/11/909

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

Code System Code Type Description

INN

9018

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

PRIMARY

MERCK INDEX

m6975

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

PRIMARY

Merck Index

PUBCHEM

16004692

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

PRIMARY

EVMPD

SUB89247

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

PRIMARY

CAS

441798-33-0

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

PRIMARY

CHEBI

76607

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

PRIMARY

RXCUI

1442132

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

PRIMARY

RxNorm

DRUG BANK

DB08932

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

PRIMARY

DRUG CENTRAL

4809

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

PRIMARY

IUPHAR

7352

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

PRIMARY

FDA UNII

Z9K9Y9WMVL

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

PRIMARY

EPA CompTox

DTXSID50196063

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

PRIMARY

SMS_ID

100000140050

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

PRIMARY

ChEMBL

CHEMBL2103873

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

PRIMARY

WIKIPEDIA

Macitentan

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

PRIMARY

USAN

YY-66

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

PRIMARY

DAILYMED

Z9K9Y9WMVL

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

PRIMARY

NCI_THESAURUS

C87728

Created by admin on Sat Dec 16 17:43:59 UTC 2023 , Edited by admin on Sat Dec 16 17:43:59 UTC 2023

PRIMARY

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PLASMA PROTEIN FRACTION (HUMAN)

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					MZI81HV01P

METABOLITE ACTIVE -> PARENT


					WGC4HS91NY

(2S,3S,4S,5R,6R)-6-((5-(4-BROMOPHENYL)-6-(2-(5-BROMOPYRIMIDIN-2-YL)OXYETHOXY)PYRIMIDIN-4-YL)SULFAMOYLAMINO)-3,4,5-TRIHYDROXY-TETRAHYDROPYRAN-2-CARBOXYLIC ACID

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Amount:


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Amount:


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N-(5-(4-BROMOPHENYL)-6-(2-HYDROXYETHOXY)-4-PYRIMIDINYL)-N'-PROPYLSULFAMIDE

METABOLITE -> PARENT

Amount:


					51YSQ21S7O

5-(4-BROMOPHENYL)-6-(2-((5-BROMO-2-PYRIMIDINYL)OXY)ETHOXY)-4-PYRIMIDINAMINE

METABOLITE -> PARENT

Amount:

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ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Tmax	PHARMACOKINETIC				ORAL ADMINISTRATION

Biological Half-life	PHARMACOKINETIC