ROSIGLITAZONE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H19N3O3S
Molecular Weight	357.427
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ROSIGLITAZONE

Structure Search

SMILES

CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C3=CC=CC=N3

InChI

InChIKey=YASAKCUCGLMORW-UHFFFAOYSA-N

InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23)

HIDE SMILES / InChI

Molecular Formula	C18H19N3O3S
Molecular Weight	357.427
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:18:29 UTC 2023` Edited by `admin` on `Fri Dec 15 16:18:29 UTC 2023`
Record UNII	05V02F2KDG
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ROSIGLITAZONE

Official Name

English

ROSIGLIZOLE

Brand Name

English

BRL-49653

Code

English

NSC-758698

Code

English

ROSIGLITAZONE [MI]

Common Name

English

rosiglitazone [INN]

Common Name

English

ROSIGLITAZONE [EMA EPAR]

Common Name

English

REZULT

Brand Name

English

TDZ-01

Code

English

ROSIGLITAZONE [VANDF]

Common Name

English

2,4-THIAZOLIDINEDIONE, 5-((4-(2-(METHYL-2-PYRIDINYLAMINO)ETHOXY)PHENYL)METHYL)-

Systematic Name

English

ROSIGLITAZONE [MART.]

Common Name

English

ROSIGLITAZONE [IARC]

Common Name

English

ROSVEL

Brand Name

English

GAUDIL

Brand Name

English

5-((4-(2-(METHYL-2-PYRIDINYLAMINO)ETHOXY)PHENYL)METHYL)-2,4-THIAZOLIDINEDIONE

Systematic Name

English

ROSIGLITAZONE [HSDB]

Common Name

English

Rosiglitazone [WHO-DD]

Common Name

English

5-(4-(2-(N-METHYL-N-(2-PYRIDINYL)AMINO)ETHOXY)BENZYL)-2,4-THIAZOLIDINEDIONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C98241

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

NDF-RT

N0000011272

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

WHO-ATC

A10BD03

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

LIVERTOX

NBK548114

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

NDF-RT

N0000180190

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

WHO-ATC

A10BD04

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

WHO-VATC

QA10BG02

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

NDF-RT

N0000175374

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

NCI_THESAURUS

C1934

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

WHO-VATC

QA10BD04

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

WHO-ATC

A10BG02

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

NDF-RT

N0000170119

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

NDF-RT

N0000011272

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

WHO-VATC

QA10BD03

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

NDF-RT

N0000180186

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

NDF-RT

N0000170119

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

NDF-RT

N0000011272

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

Code System Code Type Description

SMS_ID

100000089168

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

EVMPD

SUB10388MIG

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

DRUG CENTRAL

2405

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

INN

7662

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

PUBCHEM

77999

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

HSDB

7555

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

DRUG BANK

DB00412

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

NSC

758698

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

LACTMED

Rosiglitazone

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

WIKIPEDIA

ROSIGLITAZONE

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

IUPHAR

1056

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

DAILYMED

05V02F2KDG

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

CHEBI

50122

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

MESH

C089730

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

NCI_THESAURUS

C62076

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

EPA CompTox

DTXSID7037131

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

MERCK INDEX

m9666

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

Merck Index

CAS

122320-73-4

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

ChEMBL

CHEMBL121

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

FDA UNII

05V02F2KDG

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

RXCUI

84108

Created by admin on Fri Dec 15 16:18:29 UTC 2023 , Edited by admin on Fri Dec 15 16:18:29 UTC 2023

PRIMARY

RxNorm

Related Record Type Details


					ONY583280Z

OCT-1

TRANSPORTER -> INHIBITOR


					AIN96D6SGL

OATP1B1

TRANSPORTER -> INHIBITOR


					L0423Z5LDW

CYTOCHROME P450 2C8

METABOLIC ENZYME -> SUBSTRATE


					AL17N8ZSWL

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA

TARGET -> INHIBITOR

Comments:

Binding Assay

Qualification:

IC50

Amount:


					2V3E7D3089

ROSIGLITAZONE POTASSIUM

SALT/SOLVATE -> PARENT


					66DDF797LP

OATP-8

TRANSPORTER -> INHIBITOR


					KX2339DP44

ROSIGLITAZONE MALEATE

SALT/SOLVATE -> PARENT


					6L2K7RBQ5H

ROSIGLITAZONE, (S)-

ENANTIOMER -> RACEMATE


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					3DQ9JH6CDA

Rosiglitazone tartrate

SALT/SOLVATE -> PARENT

Amount:


					G49RZO51ZC

OATP-B

TRANSPORTER -> INHIBITOR

Comments:

SUBSTRATE USED: Bromsulphthalein (BSP)


					YR4MBO751R

ROSIGLITAZONE SODIUM

SALT/SOLVATE -> PARENT


					KX2339DP44

ROSIGLITAZONE MALEATE

SALT/SOLVATE -> PARENT


					S3055SS582

ROSIGLITAZONE HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					533QLZ62ZS

ROSIGLITAZONE FUMARATE

SALT/SOLVATE -> PARENT


					386X2T4SQV

ROSIGLITAZONE CHOLINATE

SALT/SOLVATE -> PARENT


					3U8PBH2BON

ROSIGLITAZONE, (R)-

ENANTIOMER -> RACEMATE

Related Record Type Details


					4M9C7Y2OLR

N-DESMETHYL-O-HYDROXY ROSIGLITAZONE

METABOLITE INACTIVE -> PARENT

Interaction Type:

MINOR

Amount:


					005173PK6V

P-HYDROXY ROSIGLITAZONE

METABOLITE ACTIVE -> PARENT

Interaction Type:

MAJOR

Amount:

Related Record Type Details


					05V02F2KDG

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC