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Details

Stereochemistry ACHIRAL
Molecular Formula C17H15BrF2N4O3
Molecular Weight 441.227
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Binimetinib

SMILES

CN1C=NC2=C(F)C(NC3=C(F)C=C(Br)C=C3)=C(C=C12)C(=O)NOCCO

InChI

InChIKey=ACWZRVQXLIRSDF-UHFFFAOYSA-N
InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

HIDE SMILES / InChI
Molecular Formula C17H15BrF2N4O3
Molecular Weight 441.227
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
123738
Substance Class Chemical
Created
by admin
on Sat Dec 16 16:05:44 UTC 2023
Edited
by admin
on Sat Dec 16 16:05:44 UTC 2023
Record UNII
181R97MR71
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Binimetinib
INN   USAN   WHO-DD  
INN   USAN  
Official Name English
1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-
Systematic Name English
binimetinib [INN]
Common Name English
BINIMETINIB [USAN]
Common Name English
BINIMETINIB [JAN]
Common Name English
5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
Systematic Name English
MEK162
Code English
Binimetinib [WHO-DD]
Common Name English
ARRY-438162
Code English
MEKTOVI
Brand Name English
BINIMETINIB [MI]
Common Name English
NVP-MEK162
Code English
ARRY-162
Code English
BINIMETINIB [ORANGE BOOK]
Common Name English
6-[(4-bromo-2-fluorophenyl)amino]-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
Systematic Name English
MEK-162
Code English
Classification Tree Code System Code
FDA ORPHAN DRUG 440414
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
NCI_THESAURUS C69145
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
NCI_THESAURUS C129825
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
WHO-ATC L01XE41
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
FDA ORPHAN DRUG 411613
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
FDA ORPHAN DRUG 411513
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
Code System Code Type Description
NCI_THESAURUS
C84865
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
PRIMARY
EVMPD
SUB179942
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
PRIMARY
INN
9764
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
PRIMARY
DAILYMED
181R97MR71
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
PRIMARY
USAN
BC-93
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
PRIMARY
CAS
606143-89-9
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
PRIMARY
DRUG CENTRAL
5290
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
PRIMARY
MERCK INDEX
m12078
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
PRIMARY
PUBCHEM
10288191
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
PRIMARY
FDA UNII
181R97MR71
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
PRIMARY
EPA CompTox
DTXSID70209422
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
PRIMARY
WIKIPEDIA
Binimetinib
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
PRIMARY
LACTMED
Binimetinib
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
PRIMARY
SMS_ID
100000165993
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
PRIMARY
ChEMBL
CHEMBL3187723
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
PRIMARY
CHEBI
145371
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
PRIMARY
RXCUI
2049122
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
PRIMARY
DRUG BANK
DB11967
Created by admin on Sat Dec 16 16:05:46 UTC 2023 , Edited by admin on Sat Dec 16 16:05:46 UTC 2023
PRIMARY
Related Record Type Details
CYTOCHROME P450 1A2
METABOLIC ENZYME -> SUBSTRATE
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
Structure of Binimetinib
EXCRETED UNCHANGED
FECAL
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A1
METABOLIC ENZYME -> INHIBITOR
MINOR
IC50
CYTOCHROME P450 1A1
METABOLIC ENZYME -> SUBSTRATE
OCT-2
TRANSPORTER -> INHIBITOR
MINOR
IC50
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2
TRANSPORTER -> SUBSTRATE
CYTOCHROME P450 2C19
METABOLIC ENZYME -> SUBSTRATE
Structure of Binimetinib
EXCRETED UNCHANGED
URINE
MULTIDRUG RESISTANCE PROTEIN 1
TRANSPORTER -> SUBSTRATE
DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2
TARGET -> INHIBITOR
IC50
DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
TARGET -> INHIBITOR
IC50
Related Record Type Details
Structure of BINIMETINIB O-GLUCORONIDE
METABOLITE -> PARENT
MAJOR
Structure of 6-(4-BROMO-2-FLUORO-ANILINO)-7-FLUORO-N-(2-HYDROXYETHOXY)-3H-BENZIMIDAZOLE-5-CARBOXAMIDE
METABOLITE ACTIVE -> PARENT
Related Record Type Details
Structure of Binimetinib
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC DOSE

Biological Half-life PHARMACOKINETIC
Tmax PHARMACOKINETIC DOSE

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