U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C26H23FIN5O4
Molecular Weight 615.3948
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRAMETINIB

SMILES

CN1C(=O)C(C)=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC4=CC=C(I)C=C4F)C5=CC(NC(C)=O)=CC=C5

InChI

InChIKey=LIRYPHYGHXZJBZ-UHFFFAOYSA-N
InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)

HIDE SMILES / InChI
Molecular Formula C26H23FIN5O4
Molecular Weight 615.3948
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 20:39:48 UTC 2023
Edited
by admin
on Fri Dec 15 20:39:48 UTC 2023
Record UNII
33E86K87QN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TRAMETINIB
DASH   INN   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
TRAMETINIB [MI]
Common Name English
Trametinib [WHO-DD]
Common Name English
JTP 74057
Code English
JTP-74057
Code English
TMT-212
Code English
TMT212
Code English
TRAMETINIB [VANDF]
Common Name English
N-(3-{3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide
Systematic Name English
TRAMETINIB [USAN]
Common Name English
GSK1120212
Code English
GSK-1120212
Code English
ACETAMIDE, N-(3-(3-CYCLOPROPYL-5-((2-FLUORO-4-IODOPHENYL)AMINO)-3,4,6,7-TETRAHYDRO-6,8- DIMETHYL-2,4,7-TRIOXOPYRIDO(4,3-D)PYRIMIDIN-1(2H)-YL)PHENYL)-
Systematic Name English
trametinib [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C69145
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
NCI_THESAURUS C129825
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
FDA ORPHAN DRUG 376812
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
WHO-ATC L01XE25
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
EMA ASSESSMENT REPORTS MEKINIST (AUTHORIZED: MELANOMA)
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
FDA ORPHAN DRUG 882722
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
FDA ORPHAN DRUG 495915
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
WHO-VATC QL01XE25
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
FDA ORPHAN DRUG 325410
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
FDA ORPHAN DRUG 521616
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
NDF-RT N0000175605
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
Code System Code Type Description
CHEBI
75998
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
WIKIPEDIA
TRAMETINIB
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
FDA UNII
33E86K87QN
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
SMS_ID
100000143251
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
EPA CompTox
DTXSID901007381
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
EVMPD
SUB119776
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
INN
9421
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
CHEBI
75991
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
DAILYMED
33E86K87QN
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
PUBCHEM
11707110
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
NCI_THESAURUS
C77908
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
LACTMED
Trametinib
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
DRUG CENTRAL
4802
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
MERCK INDEX
m11718
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
ChEMBL
CHEMBL2103875
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
DRUG BANK
DB08911
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
RXCUI
1425099
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY RxNorm
USAN
XX-79
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
IUPHAR
6495
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
CAS
871700-17-3
Created by admin on Fri Dec 15 20:39:48 UTC 2023 , Edited by admin on Fri Dec 15 20:39:48 UTC 2023
PRIMARY
Related Record Type Details
Structure of Trametinib acetate
SALT/SOLVATE -> PARENT
Structure of TRAMETINIB DIMETHYL SULFOXIDE
SALT/SOLVATE -> PARENT
DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1
TARGET -> INHIBITOR
MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2
TARGET -> INHIBITOR
Related Record Type Details
Structure of DESACETYL TRAMETINIB N-GLUCORONIDE
METABOLITE INACTIVE -> PARENT
AMOUNT ADMINISTERED
PLASMA
Structure of 1-(3-AMINO-4-HYDROXY-PHENYL)-3-CYCLOPROPYL-5-(2-FLUORO-4-IODO-ANILINO)-6,8-DIMETHYL-PYRIDO(4,3-D)PYRIMIDINE-2,4,7-TRIONE
METABOLITE -> PARENT
STUDIED IN TWO PATIENTS NOT DETECTED IN ONE PATIENT
AMOUNT EXCRETED
URINE
Structure of 1-(3-AMINO-4-HYDROXY-PHENYL)-3-CYCLOPROPYL-5-(2-FLUORO-4-IODO-ANILINO)-6,8-DIMETHYL-PYRIDO(4,3-D)PYRIMIDINE-2,4,7-TRIONE
METABOLITE -> PARENT
PLASMA
Structure of TRAMETINIB, DESACETYL
METABOLITE ACTIVE -> PARENT
TWO PATIENTS STUDIED METABOLITE BELOW LLQ IN ONE PATIENT
MINOR
URINE
Structure of 1-(3-AMINO-4-HYDROXY-PHENYL)-3-CYCLOPROPYL-5-(2-FLUORO-4-IODO-ANILINO)-6,8-DIMETHYL-PYRIDO(4,3-D)PYRIMIDINE-2,4,7-TRIONE
METABOLITE -> PARENT
STUDIED IN TWO PATIENTS NOT DETECTED IN ONE PATIENT
AMOUNT EXCRETED
FECAL
Structure of 3-CYCLOPROPYL-5-((2-FLUORO-4-IODOPHENYL)AMINO)-1-(3-((HYDROXYACETYL)AMINO)PHENYL)-6,8-DIMETHYL-2,4,7-TRIOXO-3,4,6,7-TETRAHYDRO-2H-PYRIDO(4,3-D)PYRIMIDINE
METABOLITE -> PARENT
NO QUANTITY LISTED
MINOR
URINE
Structure of 1-(3-AMINO-4-HYDROXY-PHENYL)-3-CYCLOPROPYL-5-(2-FLUORO-4-IODO-ANILINO)-6,8-DIMETHYL-PYRIDO(4,3-D)PYRIMIDINE-2,4,7-TRIONE
METABOLITE -> PARENT
FECAL; PLASMA; URINE
Structure of TRAMETINIB, DESACETYL
METABOLITE ACTIVE -> PARENT
FECAL; PLASMA; URINE
Structure of 1-(3-AMINO-4-HYDROXY-PHENYL)-3-CYCLOPROPYL-5-(2-FLUORO-4-IODO-ANILINO)-6,8-DIMETHYL-PYRIDO(4,3-D)PYRIMIDINE-2,4,7-TRIONE, GLUCURONIDE
METABOLITE INACTIVE -> PARENT
ONLY DETECT IN ONE PATIENT
AMOUNT EXCRETED
URINE
Related Record Type Details
Structure of TRAMETINIB
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966