SULFASALAZINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H14N4O5S
Molecular Weight	398.393
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of SULFASALAZINE

Structure Search

SMILES

OC(=O)C1=C(O)C=CC(=C1)\N=N\C2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=N3

InChI

InChIKey=NCEXYHBECQHGNR-QZQOTICOSA-N

InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+

HIDE SMILES / InChI

Molecular Formula	C18H14N4O5S
Molecular Weight	398.393
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:46:47 UTC 2023` Edited by `admin` on `Fri Dec 15 15:46:47 UTC 2023`
Record UNII	3XC8GUZ6CB
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SULFASALAZINE

Official Name

English

SULFASALAZINE [USAN]

Common Name

English

sulfasalazine [INN]

Common Name

English

SULFASALAZINE [ORANGE BOOK]

Common Name

English

SALAZOSULFAPYRIDINE [JAN]

Common Name

English

SALAZOPYRIN

Brand Name

English

SULFASALAZINE [EP MONOGRAPH]

Common Name

English

SULFASALAZINE [MART.]

Common Name

English

SULFASALAZINE [MI]

Common Name

English

SULFASALAZINE [USP-RS]

Common Name

English

SULFASALAZINE [VANDF]

Common Name

English

SULFASALAZINUM [WHO-IP LATIN]

Common Name

English

AZULFIDINE

Brand Name

English

SALICYLAZOSULFAPYRIDINE

Common Name

English

NSC-203730

Code

English

NSC-667219

Code

English

Sulfasalazine [WHO-DD]

Common Name

English

SULFASALAZINE [USP MONOGRAPH]

Common Name

English

BENZOSULFA

Common Name

English

SULFASALAZINE [IARC]

Common Name

English

SULFASALAZOPYRIDINE

Common Name

English

SULFASALAZINE [WHO-IP]

Common Name

English

2-HYDROXY-5-((4-((2-PYRIDINYLAMINO)SULFONYL)PHENYL)AZO)BENZOIC ACID [WHO-IP]

Common Name

English

BENZOIC ACID, 2-HYDROXY-5-(2-(4-((2-PYRIDINYLAMINO)SULFONYL)PHENYL)DIAZENYL)-

Systematic Name

English

SULFASALAZINE [HSDB]

Common Name

English

SULPHASALAZINE

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000005760

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

NDF-RT

N0000005760

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

WHO-VATC

QA07EC01

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

NCI_THESAURUS

C257

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

LIVERTOX

NBK548792

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

NDF-RT

N0000005760

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

NDF-RT

N0000175781

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

2.4

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

WHO-ATC

A07EC01

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

17.3

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

NDF-RT

N0000005760

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

Code System Code Type Description

MESH

D012460

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

EPA CompTox

DTXSID0021256

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

FDA UNII

3XC8GUZ6CB

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

NCI_THESAURUS

C29469

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

INN

2210

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

CAS

599-79-1

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

DRUG CENTRAL

2525

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

DAILYMED

3XC8GUZ6CB

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

NSC

203730

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

RS_ITEM_NUM

1636005

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

EVMPD

SUB20720

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

RXCUI

9524

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

RxNorm

NSC

667219

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

EVMPD

SUB10727MIG

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

SMS_ID

100000091572

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

WHO INTERNATIONAL PHARMACOPEIA

SULFASALAZINE

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

Description: A bright yellow to brownish yellow powder; odourless. Solubility: Practically insoluble in water and ether R; very slightly soluble in ethanol (~750 g/l) TS; soluble in alkali hydroxides. Category: Antibacterial drug. Storage: Sulfasalazine should be kept in a tightly closed container, protected from light. Additional information: Sulfasalazine melts at about 255?C with decomposition. Definition: Sulfasalazine contains not less than 93.0% and not more than 103.0% of C18H14N4O5S, calculated with reference to the dried substance.

DRUG BANK

DB00795

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

HSDB

3395

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

ECHA (EC/EINECS)

209-974-3

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

MERCK INDEX

m10343

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

Merck Index

ChEMBL

CHEMBL421

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

IUPHAR

4840

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

WIKIPEDIA

Sulfasalazine

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

CHEBI

9334

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

LACTMED

Sulfasalazine

Created by admin on Fri Dec 15 15:46:48 UTC 2023 , Edited by admin on Fri Dec 15 15:46:48 UTC 2023

PRIMARY

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PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA

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ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2

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TARGET -> INHIBITOR

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					7V624678YX

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METABOLIC ENZYME -> SUBSTRATE

Amount:


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BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

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EP

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					ZWJ2Y6JZWY

OAT-3

TRANSPORTER -> INHIBITOR

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					4Q81I59GXC

METABOLITE ACTIVE -> PARENT

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Inhibite the Hb-catalyzed peroxidative reaction

Amount:


					Y5V2N1KE8U

METABOLITE INACTIVE -> PARENT

Comments:

Not inhibite the Hb-catalyzed peroxidative reaction

Amount:


					3CM4B5MZJP

ACETYLSULFAPYRIDINE

METABOLITE -> PARENT

Amount:


					9H126Z3PF5

N-ACETYL-5-AMINOSALICYLIC ACID

METABOLITE LESS ACTIVE -> PARENT

Comments:

Inhibite the Hb-catalyzed peroxidative reaction

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					D0GUO5L1MO

MORDANT YELLOW 10 FREE ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					96255OEK8L

2-HYDROXY-3,5-BIS(2-(4-(PYRIDIN-2-YLSULFAMOYL)PHENYL)DIAZENYL)BENZOIC ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					XS57THZ3GT

4-(2-(2-HYDROXYPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					9Q73VA76OF

5-(2-(4',5-BIS(PYRIDIN-2-YLSULFAMOYL)BIPHENYL-2-YL)DIAZENYL)-2-HYDROXYBENZOIC ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					O414PZ4LPZ

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					657BS640RM

SULFASALAZINE 3-ISOMER

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					ENY1P1H0Y5

SALICYLAZOIMINOPYRIDINE

IMPURITY -> PARENT

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CHROMATOGRAPHIC PURITY (HPLC/UV)

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EP

Amount:


					Y5V2N1KE8U

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CHROMATOGRAPHIC PURITY (HPLC/UV)

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EP

Amount:


					C56X1P8LAD

4,4'-((4-HYDROXY-1,3-PHENYLENE)BIS(DIAZENEDIYL))BIS(N-(PYRIDIN-2-YL)BENZENESULFONAMIDE)

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					MH1C2K5PXT

2-HYDROXY-4'-(PYRIDIN-2-YLSULFAMOYL)-5-(2-(4-(PYRIDIN-2-YLSULFAMOYL)PHENYL)DIAZENYL)BIPHENYL-3-CARBOXYLIC ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

Related Record Type Details


					3XC8GUZ6CB

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC