Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C13H7ClF2INO2 |
| Molecular Weight | 409.554 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=C(NC2=C(Cl)C=C(I)C=C2)C(F)=C(F)C=C1
InChI
InChIKey=XCNBGWKQXRQKSA-UHFFFAOYSA-N
InChI=1S/C13H7ClF2INO2/c14-8-5-6(17)1-4-10(8)18-12-7(13(19)20)2-3-9(15)11(12)16/h1-5,18H,(H,19,20)
| Molecular Formula | C13H7ClF2INO2 |
| Molecular Weight | 409.554 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
9 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/35784712/ |
100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered: |
ZAPNOMETINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
13 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/35784712/ |
300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered: |
ZAPNOMETINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
35 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/35784712/ |
600 mg single, oral dose: 600 mg route of administration: Oral experiment type: SINGLE co-administered: |
ZAPNOMETINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
46 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/35784712/ |
900 mg single, oral dose: 900 mg route of administration: Oral experiment type: SINGLE co-administered: |
ZAPNOMETINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
84 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/35784712/ |
100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered: |
ZAPNOMETINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
157 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/35784712/ |
300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered: |
ZAPNOMETINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
411 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/35784712/ |
600 mg single, oral dose: 600 mg route of administration: Oral experiment type: SINGLE co-administered: |
ZAPNOMETINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
629 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/35784712/ |
900 mg single, oral dose: 900 mg route of administration: Oral experiment type: SINGLE co-administered: |
ZAPNOMETINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
19.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/35784712/ |
100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered: |
ZAPNOMETINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
19.8 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/35784712/ |
300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered: |
ZAPNOMETINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
21.9 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/35784712/ |
600 mg single, oral dose: 600 mg route of administration: Oral experiment type: SINGLE co-administered: |
ZAPNOMETINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
23.7 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/35784712/ |
900 mg single, oral dose: 900 mg route of administration: Oral experiment type: SINGLE co-administered: |
ZAPNOMETINIB plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 13:00:37 GMT 2025
by
admin
on
Wed Apr 02 13:00:37 GMT 2025
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| Record UNII |
4RZD8LK83V
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| Record Status |
Validated (UNII)
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| Record Version |
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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FDA ORPHAN DRUG |
853921
Created by
admin on Wed Apr 02 13:00:37 GMT 2025 , Edited by admin on Wed Apr 02 13:00:37 GMT 2025
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| Code System | Code | Type | Description | ||
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DTXSID80435811
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C183111
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11998
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4RZD8LK83V
Created by
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10112191
Created by
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303175-44-2
Created by
admin on Wed Apr 02 13:00:37 GMT 2025 , Edited by admin on Wed Apr 02 13:00:37 GMT 2025
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KL-189
Created by
admin on Wed Apr 02 13:00:37 GMT 2025 , Edited by admin on Wed Apr 02 13:00:37 GMT 2025
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300000026756
Created by
admin on Wed Apr 02 13:00:37 GMT 2025 , Edited by admin on Wed Apr 02 13:00:37 GMT 2025
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PRIMARY |
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