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Details

Stereochemistry ACHIRAL
Molecular Formula C24H23N5O
Molecular Weight 397.4723
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RIVOCERANIB

SMILES

O=C(NC1=CC=C(C=C1)C2(CCCC2)C#N)C3=CC=CN=C3NCC4=CC=NC=C4

InChI

InChIKey=WPEWQEMJFLWMLV-UHFFFAOYSA-N
InChI=1S/C24H23N5O/c25-17-24(11-1-2-12-24)19-5-7-20(8-6-19)29-23(30)21-4-3-13-27-22(21)28-16-18-9-14-26-15-10-18/h3-10,13-15H,1-2,11-12,16H2,(H,27,28)(H,29,30)

HIDE SMILES / InChI
Molecular Formula C24H23N5O
Molecular Weight 397.4723
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
123738
Substance Class Chemical
Created
by admin
on Sat Dec 16 02:11:04 UTC 2023
Edited
by admin
on Sat Dec 16 02:11:04 UTC 2023
Record UNII
5S371K6132
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RIVOCERANIB
INN  
Official Name English
rivoceranib [INN]
Common Name English
RIVOCERANIB [USAN]
Common Name English
3-PYRIDINECARBOXAMIDE, N-(4-(1-CYANOCYCLOPENTYL)PHENYL)-2-((4-PYRIDINYLMETHYL)AMINO)-
Systematic Name English
YN968D1 FREE BASE
Code English
APATINIB
Common Name English
N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide
Systematic Name English
APATINIB FREE BASE
Common Name English
Rivoceranib [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C129825
Created by admin on Sat Dec 16 02:11:04 UTC 2023 , Edited by admin on Sat Dec 16 02:11:04 UTC 2023
FDA ORPHAN DRUG 798720
Created by admin on Sat Dec 16 02:11:04 UTC 2023 , Edited by admin on Sat Dec 16 02:11:04 UTC 2023
FDA ORPHAN DRUG 682618
Created by admin on Sat Dec 16 02:11:04 UTC 2023 , Edited by admin on Sat Dec 16 02:11:04 UTC 2023
NCI_THESAURUS C1742
Created by admin on Sat Dec 16 02:11:04 UTC 2023 , Edited by admin on Sat Dec 16 02:11:04 UTC 2023
NCI_THESAURUS C1967
Created by admin on Sat Dec 16 02:11:04 UTC 2023 , Edited by admin on Sat Dec 16 02:11:04 UTC 2023
Code System Code Type Description
DRUG CENTRAL
5211
Created by admin on Sat Dec 16 02:11:04 UTC 2023 , Edited by admin on Sat Dec 16 02:11:04 UTC 2023
PRIMARY
DRUG BANK
DB14765
Created by admin on Sat Dec 16 02:11:04 UTC 2023 , Edited by admin on Sat Dec 16 02:11:04 UTC 2023
PRIMARY
USAN
FG-23
Created by admin on Sat Dec 16 02:11:04 UTC 2023 , Edited by admin on Sat Dec 16 02:11:04 UTC 2023
PRIMARY
INN
10596
Created by admin on Sat Dec 16 02:11:04 UTC 2023 , Edited by admin on Sat Dec 16 02:11:04 UTC 2023
PRIMARY
CAS
811803-05-1
Created by admin on Sat Dec 16 02:11:04 UTC 2023 , Edited by admin on Sat Dec 16 02:11:04 UTC 2023
PRIMARY
EVMPD
SUB183841
Created by admin on Sat Dec 16 02:11:04 UTC 2023 , Edited by admin on Sat Dec 16 02:11:04 UTC 2023
PRIMARY
PUBCHEM
11315474
Created by admin on Sat Dec 16 02:11:04 UTC 2023 , Edited by admin on Sat Dec 16 02:11:04 UTC 2023
PRIMARY
FDA UNII
5S371K6132
Created by admin on Sat Dec 16 02:11:04 UTC 2023 , Edited by admin on Sat Dec 16 02:11:04 UTC 2023
PRIMARY
SMS_ID
100000170007
Created by admin on Sat Dec 16 02:11:04 UTC 2023 , Edited by admin on Sat Dec 16 02:11:04 UTC 2023
PRIMARY
EPA CompTox
DTXSID601024366
Created by admin on Sat Dec 16 02:11:04 UTC 2023 , Edited by admin on Sat Dec 16 02:11:04 UTC 2023
PRIMARY
NCI_THESAURUS
C152237
Created by admin on Sat Dec 16 02:11:04 UTC 2023 , Edited by admin on Sat Dec 16 02:11:04 UTC 2023
PRIMARY
Related Record Type Details
CYTOCHROME P450 3A5
METABOLIC ENZYME -> SUBSTRATE
CYTOCHROME P450 2D6
METABOLIC ENZYME -> SUBSTRATE
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA
TARGET -> INHIBITOR
IC50
CYTOCHROME P450 2C9
METABOLIC ENZYME -> SUBSTRATE
CYTOCHROME P450 2E1
METABOLIC ENZYME -> SUBSTRATE
Structure of RIVOCERANIB
EXCRETED UNCHANGED
URINE
Structure of RIVOCERANIB
EXCRETED UNCHANGED
FECAL
Structure of Rivoceranib Mesylate
SALT/SOLVATE -> PARENT
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B7
METABOLIC ENZYME -> SUBSTRATE
VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
TARGET -> INHIBITOR
SELECTIVE
IC50
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A4
METABOLIC ENZYME -> SUBSTRATE
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
MAJOR
Related Record Type Details
Structure of 3-HYDROXY-APATINIB, CIS-
METABOLITE -> PARENT
MAJOR
PLASMA
Structure of 2-Amino-N-(4-(1-cyanocyclopentyl)phenyl)nicotinamide
METABOLITE -> PARENT
Structure of 3-HYDROXY-N-(DEPYRIDINYLMETHYL)-APATINIB, TRANS-
METABOLITE -> PARENT
Structure of 3-HYDROXY-N-(DEPYRIDINYLMETHYL)-APATINIB, CIS-
METABOLITE -> PARENT
Structure of APATINIB-25-N-OXIDE
METABOLITE -> PARENT
MAJOR
PLASMA
Structure of 3-HYDROXY-APATINIB, TRANS-
METABOLITE -> PARENT
MAJOR
PLASMA
Related Record Type Details
Structure of RIVOCERANIB
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Tmax PHARMACOKINETIC ORAL ADMINISTRATION

AT DAY 28

ONCE DAILY

DOSE

Biological Half-life PHARMACOKINETIC ORAL ADMINISTRATION

DOSE

ONCE DAILY

AT DAY 28

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