U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 18:46:53 GMT 2025
Edited
by admin
on Tue Apr 01 18:46:53 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
798536Z7S0
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2
Common Name English
CD309
Preferred Name English
KDR
Common Name English
FETAL LIVER KINASE 1
Common Name English
PROTEIN-TYROSINE KINASE RECEPTOR FLK-1
Common Name English
VEGFR-2
Common Name English
FLK-1
Common Name English
KINASE INSERT DOMAIN RECEPTOR
Common Name English
Code System Code Type Description
UNIPROT
P35968
Created by admin on Tue Apr 01 18:46:53 GMT 2025 , Edited by admin on Tue Apr 01 18:46:53 GMT 2025
PRIMARY
EC (ENZYME CLASS)
EC 2.7.10.1
Created by admin on Tue Apr 01 18:46:53 GMT 2025 , Edited by admin on Tue Apr 01 18:46:53 GMT 2025
PRIMARY
FDA UNII
798536Z7S0
Created by admin on Tue Apr 01 18:46:53 GMT 2025 , Edited by admin on Tue Apr 01 18:46:53 GMT 2025
PRIMARY
WIKIPEDIA
KINASE INSERT DOMAIN RECEPTOR
Created by admin on Tue Apr 01 18:46:53 GMT 2025 , Edited by admin on Tue Apr 01 18:46:53 GMT 2025
PRIMARY
From To
1_34 1_84
1_131 1_181
1_227 1_288
1_426 1_511
1_552 1_623
1_669 1_718
1_1005 1_1026
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_27
N 1_47
N 1_77
N 1_124
N 1_139
N 1_226
N 1_299
N 1_355
N 1_376
N 1_492
N 1_504
N 1_561
N 1_594
N 1_600
N 1_612
N 1_656
N 1_685
N 1_702
Related Record Type Details
Structure of RIVOCERANIB
INHIBITOR -> TARGET
SELECTIVE
IC50
Structure of ALTIRATINIB
INHIBITOR -> TARGET
Structure of CEP-11981
INHIBITOR -> TARGET
IC50
Structure of ODM-203
INHIBITOR -> TARGET
IC50
Structure of Axitinib
INHIBITOR -> TARGET
Structure of Tinengotinib
INHIBITOR -> TARGET
Structure of PF-337210
INHIBITOR -> TARGET
Structure of LENVATINIB
INHIBITOR -> TARGET
Structure of PEXMETINIB
INHIBITOR -> TARGET
ALACIZUMAB PEGOL
INHIBITOR -> TARGET
Structure of SORAFENIB
INHIBITOR -> TARGET
Structure of BMS-690514
INHIBITOR -> TARGET
Structure of REGORAFENIB ANHYDROUS
INHIBITOR -> TARGET
Structure of SUNITINIB
INHIBITOR -> TARGET
Structure of CP-547632
INHIBITOR -> TARGET
Structure of TIMTRAXANIB
INHIBITOR -> TARGET
Structure of ILORASERTIB
INHIBITOR -> TARGET
Structure of Pralsetinib
INHIBITOR->OFF-TARGET
IC50
Structure of GLESATINIB
INHIBITOR -> TARGET
Structure of SU-14813
INHIBITOR -> TARGET
Structure of PONATINIB
INHIBITOR -> TARGET
Structure of DMBI
INHIBITOR -> TARGET
Structure of Cabozantinib
INHIBITOR -> TARGET
IC50
Structure of VOROLANIB
INHIBITOR -> TARGET
Structure of OSI-930
INHIBITOR -> TARGET
COMPETITIVE INHIBITOR
Structure of BFH-772
INHIBITOR -> TARGET
VARISACUMAB
INHIBITOR -> TARGET
Structure of SURUFATINIB
INHIBITOR -> TARGET
PULOCIMAB
LIGAND->TARGET
Structure of 6-(4-METHOXYPHENYL)-3-(3-THIENYL)-PYRAZOLO(1,5-A)PYRIMIDINE
INHIBITOR -> TARGET
Structure of VEGFR 2 KINASE INHIBITOR II
INHIBITOR -> TARGET
Structure of FORETINIB
INHIBITOR -> TARGET
Structure of BRIVANIB
INHIBITOR -> TARGET
Structure of Catequentinib
INHIBITOR -> TARGET
Structure of KRN-633
INHIBITOR -> TARGET
Structure of SU-11652
INHIBITOR -> TARGET
Structure of CEDIRANIB
INHIBITOR -> TARGET
Structure of MIDOSTAURIN
INHIBITOR -> TARGET
Structure of Selpercatinib
INHIBITOR->OFF-TARGET
IC50
Structure of Nintedanib
INHIBITOR -> TARGET
Structure of TELATINIB
INHIBITOR -> TARGET
Structure of Nintedanib
INHIBITOR -> TARGET
Structure of FAMITINIB
INHIBITOR -> TARGET
Structure of ACRIZANIB
INHIBITOR -> TARGET
Structure of ORANTINIB
INHIBITOR -> TARGET
Structure of PP-121
INHIBITOR -> TARGET
PEGDINETANIB
INHIBITOR -> TARGET
Structure of JI-101
INHIBITOR -> TARGET
Structure of MOTESANIB
INHIBITOR -> TARGET
Structure of AGERAFENIB
INHIBITOR -> TARGET
IC50
Structure of SITRAVATINIB
INHIBITOR -> TARGET
Structure of AZD-2932
INHIBITOR -> TARGET
Structure of TIVOZANIB
INHIBITOR -> TARGET
IC50
Structure of N-(4-((6,7-DIMETHOXY-4-QUINOLINYL)OXY)PHENYL)-N'-(4-FLUORO-2-(SULFOOXY)PHENYL)-1,1-CYCLOPROPANEDICARBOXAMIDE
INHIBITOR -> TARGET
IC50
VULINACIMAB
INHIBITOR -> TARGET
Structure of TESEVATINIB
INHIBITOR -> TARGET
Structure of PAZOPANIB
INHIBITOR -> TARGET
Structure of ENMD-981693
INHIBITOR -> TARGET
Structure of VANDETANIB
INHIBITOR -> TARGET
Inlecitug
LIGAND->TARGET
Structure of LUCITANIB
INHIBITOR -> TARGET
Structure of FRUQUINTINIB
INHIBITOR -> TARGET
IC50
Structure of NINGETINIB
INHIBITOR -> TARGET
IC50
Structure of PAMUFETINIB
INHIBITOR -> TARGET
ATP COMPETITIVE
COMPETITIVE INHIBITOR
IC50
Structure of VEGFR 2 KINASE INHIBITOR I
INHIBITOR -> TARGET
Structure of 3-HYDROXY-APATINIB, TRANS-
INHIBITOR -> TARGET
IC50
Structure of Ibcasertib
INHIBITOR -> TARGET
IC50
Structure of Zanzalintinib
INHIBITOR -> TARGET
IC50

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_1219] THREONINE PHOSPHATE 3L4WX7B1EI
AMINO ACID SUBSTITUTION [1_932] [1_977] [1_1035] [1_1040] [1_1156] [1_1195] [1_1286] [1_1290] [1_1300] TYROSINE O-PHOSPHATE 2R86C98KDX
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966