Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C7H17NO5 |
| Molecular Weight | 195.2136 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
InChI
InChIKey=MBBZMMPHUWSWHV-BDVNFPICSA-N
InChI=1S/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1
| Molecular Formula | C7H17NO5 |
| Molecular Weight | 195.2136 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Meglumine (N-methyl-D-glucamine) is a poorly metabolized derivative of sorbitol that has regulatory acceptance as a benign excipient for drug formulation to increase aqueous solubility of lipophilic drugs and improve their absorption. In conjugated form meglumine is used as a contrast agent.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Evaluation of a specific immunochemotherapy for the treatment of canine visceral leishmaniasis. | 2002-09-06 |
|
| Cytostatic potential of novel agents that inhibit the regulation of intracellular pH. | 2002-07-15 |
|
| Chemotherapy of canine leishmaniosis. | 2002-07-02 |
|
| Unusual location of cutaneous leishmaniasis on the hallux in a Brazilian patient. | 2002-07 |
|
| Physiologic increases in extracellular sodium salt enhance coronary vasoconstriction and Ca2+ entry. | 2002-07 |
|
| Intrarenal detection of nitric oxide using electron spin resonance spectroscopy in hypertensive lipopolysaccharide-treated rats. | 2002-07 |
|
| A mechanogated nonselective cation channel in proximal tubule that is ATP sensitive. | 2002-07 |
|
| Leishmaniasis in the genital area. | 2002-06-06 |
|
| Evaluation of a rapid immunochromatographic test for serodiagnosis of visceral leishmaniasis. | 2002-06 |
|
| Phospholipase C-mediated signalling is not required for histamine-induced catecholamine secretion from bovine chromaffin cells. | 2002-06 |
|
| Visceral leishmaniasis in paediatrics. | 2002-06 |
|
| Mechanosensitive cation channels in human leukaemia cells: calcium permeation and blocking effect. | 2002-05-15 |
|
| Role of helix 3 in pore formation by the Bacillus thuringiensis insecticidal toxin Cry1Aa. | 2002-05-14 |
|
| The effect of different buffers and amounts of intestinal alkaline phosphatase isoforms on total alkaline phosphatase activity. | 2002-05-07 |
|
| In vitro susceptibility to pentavalent antimony in Leishmania infantum strains is not modified during in vitro or in vivo passages but is modified after host treatment with meglumine antimoniate. | 2002-05-02 |
|
| [Cutaneous leishmaniasis of the lid]. | 2002-05 |
|
| Leishmanicidal activity of two canthin-6-one alkaloids, two major constituents of Zanthoxylum chiloperone var. angustifolium. | 2002-05 |
|
| Intracellular pH response to anoxia in acutely dissociated adult rat hippocampal CA1 neurons. | 2002-05 |
|
| Nonselective cation conductance activated by muscarinic and purinergic receptors in rat spiral ganglion neurons. | 2002-05 |
|
| Antimony(V) complex formation with adenine nucleosides in aqueous solution. | 2002-04-15 |
|
| Analysis of lipoproteins by capillary zone electrophoresis in microfluidic devices: assay development and surface roughness measurements. | 2002-04-01 |
|
| Pediatric visceral leishmaniasis in Western Sicily, Italy: a retrospective analysis of 111 cases. | 2002-04 |
|
| Characteristics of ATP-induced current through P2X7 receptor in NG108-15 cells: unique antagonist sensitivity and lack of pore formation. | 2002-04 |
|
| Dehydroascorbic acid uptake by coronary artery smooth muscle: effect of intracellular acidification. | 2002-03-01 |
|
| Pediatric visceral leishmaniasis in Albania. | 2002-03 |
|
| An outbreak of cutaneous leishmaniasis among soldiers in Belém, Pará State, Brazil, caused by Leishmania (Viannia) lindenbergi n. sp. A new leishmanial parasite of man in the Amazon region. | 2002-03 |
|
| [Isolated laringeal leishmaniasis and bone marrow culture (reply)]. | 2002-03 |
|
| Monovalent cation permeability and Ca(2+) block of the store-operated Ca(2+) current I(CRAC )in rat basophilic leukemia cells. | 2002-03 |
|
| Dual effect of blocking agents on Ca2+-activated Cl(-) currents in rabbit pulmonary artery smooth muscle cells. | 2002-02-15 |
|
| Immunochemotherapy for cutaneous leishmaniasis: a controlled trial using killed Leishmania (Leishmania) amazonensis vaccine plus antimonial. | 2002-02 |
|
| Monitoring of total antimony and its species by ICP-MS and on-line ion chromatography in biological samples from patients treated for leishmaniasis. | 2002-02 |
|
| PCR detection of specific Leishmania-DNA in patients with periodontal disease. | 2002-02 |
|
| Gender differences in vascular smooth muscle reactivity to increases in extracellular sodium salt. | 2002-02 |
|
| Voltage-dependent cation channels permeable to NH(+)(4), K(+), and Ca(2+) in the symbiosome membrane of the model legume Lotus japonicus. | 2002-02 |
|
| Fluorescence studies of ligand-induced conformational changes of the Na(+)/glucose cotransporter. | 2002-01-29 |
|
| Characterization of the maitotoxin-activated cationic current from human skin fibroblasts. | 2002-01-01 |
|
| Na+-Ca2+ exchange activity in rat skeletal myotubes: effect of lithium ions. | 2002-01 |
|
| Leishmaniasis of the prepuce. | 2002-01 |
|
| Oral leishmaniasis in a HIV-positive patient. Report of a case involving the palate. | 2002-01 |
|
| Visceral leishmaniasis with pericarditis in an HIV-infected patient. | 2002 |
|
| Visceral childhood leishmaniasis in Turkey. | 2002 |
|
| The contributions of plasma membrane Na+-Ca2+-exchange and the Ca2+-ATPase to the regulation of cytosolic calcium ([Ca2+]i) in a clonal pituitary cell line (AtT-20) of mouse corticotropes. | 2001-12-28 |
|
| The traditional and conventional medical treatment of cutaneous leishmaniasis in rural Ecuador. | 2001-12 |
|
| Release of nitric oxide together with carbon-centered radicals from N-nitrosamines by ultraviolet light irradiation. | 2001-12 |
|
| Chemotherapy of cutaneous leishmaniasis: a review. | 2001-11 |
|
| Nitric oxide generation in aqueous solutions of cigarette smoke and approaches to its origin. | 2001-11 |
|
| [Imported cutaneous leishmaniasis caused by Leishmania infantum confirmed with immunoassay]. | 2001-10 |
|
| Background osmolyte current involved in cell volume regulation of neuroblastoma x glioma hybrid NG108-15 cells. | 2001-09 |
|
| American cutaneous leishmaniasis as a rare imported disease in Europe: a case report favourably treated with antimonial derivatives. | 2001 |
|
| Splenic granulomatous lesions in immunocompetent pediatric patients with visceral leishmaniasis. | 2001 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:25:47 GMT 2025
by
admin
on
Mon Mar 31 18:25:47 GMT 2025
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| Record UNII |
6HG8UB2MUY
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| Record Status |
Validated (UNII)
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| Record Version |
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NCI_THESAURUS |
C390
Created by
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| Code System | Code | Type | Description | ||
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228-506-9
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C61828
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100000081443
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6HG8UB2MUY
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PRIMARY | |||
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DTXSID0023244
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SUB08715MIG
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6HG8UB2MUY
Created by
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MEGLUMINE
Created by
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6284-40-8
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D008536
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5194
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7391
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52907
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CHEMBL1200570
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4205
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1379140
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6704
Created by
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PRIMARY | RxNorm | ||
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8567
Created by
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MEGLUMINE
Created by
admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
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PRIMARY | Description: A white or almost white, crystalline powder; odourless or almost odourless. Solubility: Freely soluble in water; slightly soluble in ethanol (~750 g/l) TS; practically insoluble in ether R.Category: Used in the preparation of meglumine amidotrizoate and meglumine iotroxate as radiocontrast media. Storage: Meglumine should be kept in a well-closed container.Requirements: Meglumine contains not less than 99.0% and not more than the equivalent of 100.5% of C7H17NO5, calculated with reference to the dried substance. | ||
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m7420
Created by
admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
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PRIMARY | Merck Index | ||
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59732
Created by
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